Hallmarks of Alzheimer disease are evolving relentlessly in Metropolitan Mexico City infants, children and young adults. APOE4 carriers have higher suicide risk and higher odds of reaching NFT stage V at ≤ 40 years of age

Hallmarks of Alzheimer disease are evolving relentlessly in Metropolitan Mexico City infants, children and young adults. APOE4 carriers have higher suicide risk and higher odds of reaching NFT stage V at ≤ 40 years of age

Exposures to fine particulate matter (PM2.5) and ozone (O3) above USEPA standards are associated with Alzheimer's disease (AD) risk. Metropolitan Mexico City (MMC) residents have life time exposures to PM2.5 and O3 above USEPA standards. We investigated AD intra and extracellular protein aggreg...

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Veröffentlicht in:Environmental research 2018-07, Vol.164, p.475-487
Hauptverfasser: Calderón-Garcidueñas, Lilian, Gónzalez-Maciel, Angélica, Reynoso-Robles, Rafael, Delgado-Chávez, Ricardo, Mukherjee, Partha S., Kulesza, Randy J., Torres-Jardón, Ricardo, Ávila-Ramírez, José, Villarreal-Ríos, Rodolfo
Format: Artikel
Sprache:eng
Schlagworte:
Adult
AIR POLLUTION CONTROL
Alzheimer
Alzheimer Disease - physiopathology
Amyloid beta-Peptides - metabolism
Amyloid plaques
APOE4
Apolipoprotein E4 - metabolism
APOLIPOPROTEINS
Brainstem
Child
Child, Preschool
Children
Cities
COMBUSTION
Combustion-derived nanoparticles
ENVIRONMENTAL SCIENCES
HEALTH HAZARDS
Humans
Hyperphosphorilated tau
Infant
INFANTS
Mexico
Mexico City
NANOPARTICLES
NERVOUS SYSTEM DISEASES
Neurofibrillary Tangles - metabolism
Neurofibrillary Tangles - pathology
PARTICULATES
PATHOGENESIS
PATHOLOGY
PM2.5
Suicide
Tauopathies
URBAN AREAS
Young Adult
Young adults
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