Hepatitis B virus promotes proliferation and metastasis in male Chinese hepatocellular carcinoma patients through the LEF-1/miR-371a-5p/SRCIN1/pleiotrophin/Slug pathway

Hepatocellular carcinoma (HCC) is a male-dominant cancer. Several factors may contribute to the gender difference. Recent investigations have reported that miRNAs are involved in sex-linked signaling pathways and play a critical role in the molecular pathogenesis of hepatitis B virus (HBV)-related H...

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Veröffentlicht in:	Experimental cell research 2018-09, Vol.370 (1), p.174-188
Hauptverfasser:	Bai, Pei-song, Hou, Peng, Kong, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Adaptor Proteins, Vesicular Transport - genetics Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - virology Carrier Proteins - genetics Cell Line, Tumor Cell Movement - genetics Cell Proliferation - physiology CHINA Cytokines - genetics Gene Expression Regulation, Neoplastic - genetics GROWTH FACTORS Hep G2 Cells HEPATITIS Hepatitis B - genetics Hepatitis B - pathology Hepatitis B - virology Hepatitis B virus Hepatitis B virus - pathogenicity Hepatocellular carcinoma HEPATOMAS Humans LIVER CELLS Liver Neoplasms - genetics Liver Neoplasms - pathology Liver Neoplasms - virology Lymphoid Enhancer-Binding Factor 1 - genetics Male Metastasis MicroRNAs - genetics MiR-371a-5p Neoplasm Metastasis - pathology Pleiotrophin Signal Transduction - genetics Snail Family Transcription Factors - genetics SRCIN1 TESTOSTERONE Up-Regulation - genetics VIRUSES
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