STING positively regulates human ORMDL3 expression through TBK1-IRF3-STAT6 complex mediation

Orosomucoid 1-like protein 3 (ORMDL3) is an asthma candidate gene associated with virus-triggered recurrent wheeze. Stimulator of interferon gene (STING) controls TLR-independent cytosolic responses to viruses. However, the association of STING with ORMDL3 is unclear. Here, we have shown that ORMDL3...

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Veröffentlicht in:	Experimental cell research 2018-09, Vol.370 (2), p.498-505
Hauptverfasser:	Cao, Qian, Juan, Chen-Xia, Zhang, Dao-Qi, He, Jia, Cao, Yi-Zhi, Pasha, Asfia Banu, Wang, Jin-Ya, Qi, Hai-Xiao, Li, Sheng, Jin, Rui, Zhou, Guo-Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ASTHMA INTERFERON Orosomucoid 1-like protein 3 (ORMDL3) PHOSPHORYLATION PHOSPHOTRANSFERASES POLYMERASE CHAIN REACTION Recurrent wheeze Stimulator of interferon genes (STING) TBK1-STAT6-IRF3 complex VIRUSES
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