CHD4-mediated loss of E-cadherin determines metastatic ability in triple-negative breast cancer cells

Triple-negative breast cancer (TNBC) is a subtype of cancer with aggressive behaviors (high recurrence and metastasis rate) and poor prognosis. Therefore, studying the determining factors that lead to malignant TNBCs is necessary to develop personalized therapy and improve survival rates. In this st...

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Veröffentlicht in:	Experimental cell research 2018-02, Vol.363 (1), p.65-72
Hauptverfasser:	Luo, Chi-Wen, Wu, Chun-Chieh, Chang, Shu-Jyuan, Chang, Tsung-Ming, Chen, Tzu-Yi, Chai, Chee-Yin, Chang, Chia-Lo, Hou, Ming-Feng, Pan, Mei-Ren
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Antineoplastic Agents - pharmacology BIOLOGICAL MARKERS Cadherins - metabolism Cell Line, Tumor Cell motility Cell Movement - drug effects Cell Proliferation - drug effects CHD4 Cisplatin - pharmacology DNA Drug sensitivity Epithelial-Mesenchymal Transition - drug effects Gene Expression Regulation, Neoplastic - drug effects Humans IN VITRO Lung Neoplasms - drug therapy Lung Neoplasms - metabolism MAMMARY GLANDS METASTASES Mi-2 Nucleosome Remodeling and Deacetylase Complex - metabolism Neoplasm Metastasis NEOPLASMS THERAPY Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - metabolism Triple-negative breast cancer
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