LL-37 inhibits LPS-induced inflammation and stimulates the osteogenic differentiation of BMSCs via P2X7 receptor and MAPK signaling pathway

Oral diseases, such as periapical periodontitis and periodontitis, are characterized by inflammation-induced bone loss. LL-37, a human antimicrobial peptide (AMP), has multiple biological functions and the potential to promote osteogenesis. Therefore, this study aimed to investigate the regulatory e...

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Veröffentlicht in:	Experimental cell research 2018-11, Vol.372 (2), p.178-187
Hauptverfasser:	Yu, Xiaoran, Quan, Jingjing, Long, Weilin, Chen, Huimin, Wang, Ruoxun, Guo, Jiaxin, Lin, Xiaoxuan, Mai, Sui
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Alveolar Bone Loss - drug therapy Alveolar Bone Loss - genetics Alveolar Bone Loss - pathology Animals Antimicrobial Cationic Peptides - administration & dosage Antimicrobial peptide BONE MARROW Bone marrow stromal cells Cell Differentiation - drug effects Cell Proliferation - drug effects Cellular Microenvironment - drug effects Gene Expression Regulation, Developmental - drug effects Humans Inflammation - chemically induced Inflammation - drug therapy Inflammation - genetics Inflammation - pathology LIPOPOLYSACCHARIDES Lipopolysaccharides - toxicity LL-37 LYMPHOKINES MAPK Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - metabolism MICE Mitogen-Activated Protein Kinase Kinases - genetics NF-kappa B - genetics Osteogenesis - drug effects Osteogenesis - genetics P2X7 receptor PHOSPHORUS 38 Phosphorylation - drug effects PHOSPHOTRANSFERASES RECEPTORS Receptors, Purinergic P2X7 - drug effects Signal Transduction - drug effects
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