Clinical Outcomes of Transcatheter Arterial Embolisation for Chronic Knee Pain: Mild-to-Moderate Versus Severe Knee Osteoarthritis

Purpose This retrospective study was conducted to compare the clinical outcomes of transcatheter arterial embolisation for chronic knee pain in patients with mild-to-moderate versus severe knee osteoarthritis. Materials and Methods This study included patients ( n  = 41) who were refractory to conse...

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Veröffentlicht in:Cardiovascular and interventional radiology 2019-11, Vol.42 (11), p.1530-1536
Hauptverfasser: Lee, Sang Hwan, Hwang, Jin Ho, Kim, Dong Hyun, So, Young Ho, Park, Jihong, Cho, Soo Buem, Kim, Jeong-Eun, Kim, Young Jae, Hur, Saebeom, Jae, Hwan Jun
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container_end_page 1536
container_issue 11
container_start_page 1530
container_title Cardiovascular and interventional radiology
container_volume 42
creator Lee, Sang Hwan
Hwang, Jin Ho
Kim, Dong Hyun
So, Young Ho
Park, Jihong
Cho, Soo Buem
Kim, Jeong-Eun
Kim, Young Jae
Hur, Saebeom
Jae, Hwan Jun
description Purpose This retrospective study was conducted to compare the clinical outcomes of transcatheter arterial embolisation for chronic knee pain in patients with mild-to-moderate versus severe knee osteoarthritis. Materials and Methods This study included patients ( n  = 41) who were refractory to conservative treatments and who underwent transcatheter arterial embolisation using imipenem/cilastatin sodium between June 2017 and July 2018. A total of 71 knees, including 30 bilateral cases, were treated and categorised into two groups according to the Kellgren–Lawrence grade: mild-to-moderate osteoarthritis ( n  = 59, Kellgren–Lawrence grade 1–3) and severe osteoarthritis ( n  = 12, Kellgren–Lawrence grade 4). The clinical outcomes were measured by the visual analogue scale score. Results There were no significant differences in age, body mass index or baseline visual analogue scale scores between the two groups. The mean visual analogue scale scores in the mild-to-moderate osteoarthritis group were significantly decreased at 1 day, 1 week, 1 month, 3 months, and 6-months (5.5 at baseline vs. 3.2, 3.1, 2.9, 2.2, and 1.9, after treatment; all P  = .00). These improvements were maintained at a mean of 10 ± 3 months (range 6–19 months) post-treatment. The visual analogue scale scores were significantly decreased in the severe osteoarthritis group for 1 month post-treatment (6.3 at baseline vs. 4.1, 4.1, and 4.4 at 1 day, 1 week, and 1 month; all P  
doi_str_mv 10.1007/s00270-019-02289-4
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Materials and Methods This study included patients ( n  = 41) who were refractory to conservative treatments and who underwent transcatheter arterial embolisation using imipenem/cilastatin sodium between June 2017 and July 2018. A total of 71 knees, including 30 bilateral cases, were treated and categorised into two groups according to the Kellgren–Lawrence grade: mild-to-moderate osteoarthritis ( n  = 59, Kellgren–Lawrence grade 1–3) and severe osteoarthritis ( n  = 12, Kellgren–Lawrence grade 4). The clinical outcomes were measured by the visual analogue scale score. Results There were no significant differences in age, body mass index or baseline visual analogue scale scores between the two groups. The mean visual analogue scale scores in the mild-to-moderate osteoarthritis group were significantly decreased at 1 day, 1 week, 1 month, 3 months, and 6-months (5.5 at baseline vs. 3.2, 3.1, 2.9, 2.2, and 1.9, after treatment; all P  = .00). These improvements were maintained at a mean of 10 ± 3 months (range 6–19 months) post-treatment. The visual analogue scale scores were significantly decreased in the severe osteoarthritis group for 1 month post-treatment (6.3 at baseline vs. 4.1, 4.1, and 4.4 at 1 day, 1 week, and 1 month; all P  &lt; .01). However, a decrease in pain was not statistically significant from 3 to 6 months (5.4 and 5.9 at 3 months and 6 months, respectively). Conclusion Transcatheter arterial embolisation effectively relieved pain in patients with mild-to-moderate osteoarthritis. In patients with severe osteoarthritis, pain severity decreased for 1 month but gradually increased to the initial severity score within 3 months. Level of Evidence 4, Case series.</description><identifier>ISSN: 0174-1551</identifier><identifier>EISSN: 1432-086X</identifier><identifier>DOI: 10.1007/s00270-019-02289-4</identifier><identifier>PMID: 31338552</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Arterial Interventions ; Arthralgia - etiology ; Arthralgia - therapy ; Arthritis ; Biocompatibility ; BIOMEDICAL RADIOGRAPHY ; Body mass ; Body mass index ; Body size ; BONE JOINTS ; Cardiology ; Chronic pain ; Chronic Pain - etiology ; Chronic Pain - therapy ; Clinical Investigation ; Clinical outcomes ; Embolization, Therapeutic - methods ; Female ; Follow-Up Studies ; Humans ; Imaging ; Imipenem ; Knee ; Male ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; Nuclear Medicine ; Osteoarthritis ; Osteoarthritis, Knee - complications ; Osteoarthritis, Knee - therapy ; PAIN ; PATIENTS ; Radiology ; RADIOLOGY AND NUCLEAR MEDICINE ; Retrospective Studies ; Severity of Illness Index ; SKELETAL DISEASES ; Sodium ; Statistical analysis ; Treatment Outcome ; Ultrasound</subject><ispartof>Cardiovascular and interventional radiology, 2019-11, Vol.42 (11), p.1530-1536</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2019</rights><rights>CardioVascular and Interventional Radiology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-514ae251f39d1ea0a506338bed2e061c4de82ab9671be241225347ecb279e4893</citedby><cites>FETCH-LOGICAL-c469t-514ae251f39d1ea0a506338bed2e061c4de82ab9671be241225347ecb279e4893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00270-019-02289-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00270-019-02289-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,315,782,786,887,27931,27932,41495,42564,51326</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31338552$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22970452$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Sang Hwan</creatorcontrib><creatorcontrib>Hwang, Jin Ho</creatorcontrib><creatorcontrib>Kim, Dong Hyun</creatorcontrib><creatorcontrib>So, Young Ho</creatorcontrib><creatorcontrib>Park, Jihong</creatorcontrib><creatorcontrib>Cho, Soo Buem</creatorcontrib><creatorcontrib>Kim, Jeong-Eun</creatorcontrib><creatorcontrib>Kim, Young Jae</creatorcontrib><creatorcontrib>Hur, Saebeom</creatorcontrib><creatorcontrib>Jae, Hwan Jun</creatorcontrib><title>Clinical Outcomes of Transcatheter Arterial Embolisation for Chronic Knee Pain: Mild-to-Moderate Versus Severe Knee Osteoarthritis</title><title>Cardiovascular and interventional radiology</title><addtitle>Cardiovasc Intervent Radiol</addtitle><addtitle>Cardiovasc Intervent Radiol</addtitle><description>Purpose This retrospective study was conducted to compare the clinical outcomes of transcatheter arterial embolisation for chronic knee pain in patients with mild-to-moderate versus severe knee osteoarthritis. Materials and Methods This study included patients ( n  = 41) who were refractory to conservative treatments and who underwent transcatheter arterial embolisation using imipenem/cilastatin sodium between June 2017 and July 2018. A total of 71 knees, including 30 bilateral cases, were treated and categorised into two groups according to the Kellgren–Lawrence grade: mild-to-moderate osteoarthritis ( n  = 59, Kellgren–Lawrence grade 1–3) and severe osteoarthritis ( n  = 12, Kellgren–Lawrence grade 4). The clinical outcomes were measured by the visual analogue scale score. Results There were no significant differences in age, body mass index or baseline visual analogue scale scores between the two groups. The mean visual analogue scale scores in the mild-to-moderate osteoarthritis group were significantly decreased at 1 day, 1 week, 1 month, 3 months, and 6-months (5.5 at baseline vs. 3.2, 3.1, 2.9, 2.2, and 1.9, after treatment; all P  = .00). These improvements were maintained at a mean of 10 ± 3 months (range 6–19 months) post-treatment. The visual analogue scale scores were significantly decreased in the severe osteoarthritis group for 1 month post-treatment (6.3 at baseline vs. 4.1, 4.1, and 4.4 at 1 day, 1 week, and 1 month; all P  &lt; .01). However, a decrease in pain was not statistically significant from 3 to 6 months (5.4 and 5.9 at 3 months and 6 months, respectively). Conclusion Transcatheter arterial embolisation effectively relieved pain in patients with mild-to-moderate osteoarthritis. In patients with severe osteoarthritis, pain severity decreased for 1 month but gradually increased to the initial severity score within 3 months. Level of Evidence 4, Case series.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arterial Interventions</subject><subject>Arthralgia - etiology</subject><subject>Arthralgia - therapy</subject><subject>Arthritis</subject><subject>Biocompatibility</subject><subject>BIOMEDICAL RADIOGRAPHY</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>BONE JOINTS</subject><subject>Cardiology</subject><subject>Chronic pain</subject><subject>Chronic Pain - etiology</subject><subject>Chronic Pain - therapy</subject><subject>Clinical Investigation</subject><subject>Clinical outcomes</subject><subject>Embolization, Therapeutic - methods</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Imaging</subject><subject>Imipenem</subject><subject>Knee</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Middle Aged</subject><subject>Nuclear Medicine</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis, Knee - complications</subject><subject>Osteoarthritis, Knee - therapy</subject><subject>PAIN</subject><subject>PATIENTS</subject><subject>Radiology</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><subject>SKELETAL DISEASES</subject><subject>Sodium</subject><subject>Statistical analysis</subject><subject>Treatment Outcome</subject><subject>Ultrasound</subject><issn>0174-1551</issn><issn>1432-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU9v1DAQxS0EotuFL8ABWeLCxWBP7PzhVq1KQbRaJAriZjnOhHWV2MV2kLjyyXFJWW5cZg7ze2808wh5JvgrwXnzOnEODWdcdIwDtB2TD8hGyAoYb-uvD8mGi0YyoZQ4Iacp3XAuVAvqMTmpRFW1SsGG_NpNzjtrJrpfsg0zJhpGeh2NT9bkA2aM9CyW6gpyPvdhcslkFzwdQ6S7QwxFTT94RPrROP-GXrlpYDmwqzBgNBnpF4xpSfQT_sCIK7lPGYOJ-RBddukJeTSaKeHT-74ln9-eX-_escv9xfvd2SWzsu4yU0IaBCXGqhsEGm4Ur8sVPQ6AvBZWDtiC6bu6ET2CFACqkg3aHpoOZdtVW_Ji9Q0pO52sy2gPNniPNmuAruFSQaFertRtDN8XTFnPLlmcJuMxLKmAZSuIqrSj4RG9CUv05YY7CpTsoDx6S2ClbAwpRRz1bXSziT-14PouR73mqEuO-k-OWhbR83vrpZ9xOEr-BleAagVSGflvGP_t_o_tb8aVp-0</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Lee, Sang Hwan</creator><creator>Hwang, Jin Ho</creator><creator>Kim, Dong Hyun</creator><creator>So, Young Ho</creator><creator>Park, Jihong</creator><creator>Cho, Soo Buem</creator><creator>Kim, Jeong-Eun</creator><creator>Kim, Young Jae</creator><creator>Hur, Saebeom</creator><creator>Jae, Hwan Jun</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>20191101</creationdate><title>Clinical Outcomes of Transcatheter Arterial Embolisation for Chronic Knee Pain: Mild-to-Moderate Versus Severe Knee Osteoarthritis</title><author>Lee, Sang Hwan ; Hwang, Jin Ho ; Kim, Dong Hyun ; So, Young Ho ; Park, Jihong ; Cho, Soo Buem ; Kim, Jeong-Eun ; Kim, Young Jae ; Hur, Saebeom ; Jae, Hwan Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-514ae251f39d1ea0a506338bed2e061c4de82ab9671be241225347ecb279e4893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arterial Interventions</topic><topic>Arthralgia - etiology</topic><topic>Arthralgia - therapy</topic><topic>Arthritis</topic><topic>Biocompatibility</topic><topic>BIOMEDICAL RADIOGRAPHY</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>BONE JOINTS</topic><topic>Cardiology</topic><topic>Chronic pain</topic><topic>Chronic Pain - etiology</topic><topic>Chronic Pain - therapy</topic><topic>Clinical Investigation</topic><topic>Clinical outcomes</topic><topic>Embolization, Therapeutic - methods</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Imaging</topic><topic>Imipenem</topic><topic>Knee</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Middle Aged</topic><topic>Nuclear Medicine</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis, Knee - complications</topic><topic>Osteoarthritis, Knee - therapy</topic><topic>PAIN</topic><topic>PATIENTS</topic><topic>Radiology</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><topic>SKELETAL DISEASES</topic><topic>Sodium</topic><topic>Statistical analysis</topic><topic>Treatment Outcome</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Sang Hwan</creatorcontrib><creatorcontrib>Hwang, Jin Ho</creatorcontrib><creatorcontrib>Kim, Dong Hyun</creatorcontrib><creatorcontrib>So, Young Ho</creatorcontrib><creatorcontrib>Park, Jihong</creatorcontrib><creatorcontrib>Cho, Soo Buem</creatorcontrib><creatorcontrib>Kim, Jeong-Eun</creatorcontrib><creatorcontrib>Kim, Young Jae</creatorcontrib><creatorcontrib>Hur, Saebeom</creatorcontrib><creatorcontrib>Jae, Hwan Jun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing &amp; 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Allied Health Database (Alumni Edition)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Cardiovascular and interventional radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Sang Hwan</au><au>Hwang, Jin Ho</au><au>Kim, Dong Hyun</au><au>So, Young Ho</au><au>Park, Jihong</au><au>Cho, Soo Buem</au><au>Kim, Jeong-Eun</au><au>Kim, Young Jae</au><au>Hur, Saebeom</au><au>Jae, Hwan Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Outcomes of Transcatheter Arterial Embolisation for Chronic Knee Pain: Mild-to-Moderate Versus Severe Knee Osteoarthritis</atitle><jtitle>Cardiovascular and interventional radiology</jtitle><stitle>Cardiovasc Intervent Radiol</stitle><addtitle>Cardiovasc Intervent Radiol</addtitle><date>2019-11-01</date><risdate>2019</risdate><volume>42</volume><issue>11</issue><spage>1530</spage><epage>1536</epage><pages>1530-1536</pages><issn>0174-1551</issn><eissn>1432-086X</eissn><abstract>Purpose This retrospective study was conducted to compare the clinical outcomes of transcatheter arterial embolisation for chronic knee pain in patients with mild-to-moderate versus severe knee osteoarthritis. Materials and Methods This study included patients ( n  = 41) who were refractory to conservative treatments and who underwent transcatheter arterial embolisation using imipenem/cilastatin sodium between June 2017 and July 2018. A total of 71 knees, including 30 bilateral cases, were treated and categorised into two groups according to the Kellgren–Lawrence grade: mild-to-moderate osteoarthritis ( n  = 59, Kellgren–Lawrence grade 1–3) and severe osteoarthritis ( n  = 12, Kellgren–Lawrence grade 4). The clinical outcomes were measured by the visual analogue scale score. Results There were no significant differences in age, body mass index or baseline visual analogue scale scores between the two groups. The mean visual analogue scale scores in the mild-to-moderate osteoarthritis group were significantly decreased at 1 day, 1 week, 1 month, 3 months, and 6-months (5.5 at baseline vs. 3.2, 3.1, 2.9, 2.2, and 1.9, after treatment; all P  = .00). These improvements were maintained at a mean of 10 ± 3 months (range 6–19 months) post-treatment. The visual analogue scale scores were significantly decreased in the severe osteoarthritis group for 1 month post-treatment (6.3 at baseline vs. 4.1, 4.1, and 4.4 at 1 day, 1 week, and 1 month; all P  &lt; .01). However, a decrease in pain was not statistically significant from 3 to 6 months (5.4 and 5.9 at 3 months and 6 months, respectively). Conclusion Transcatheter arterial embolisation effectively relieved pain in patients with mild-to-moderate osteoarthritis. In patients with severe osteoarthritis, pain severity decreased for 1 month but gradually increased to the initial severity score within 3 months. Level of Evidence 4, Case series.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31338552</pmid><doi>10.1007/s00270-019-02289-4</doi><tpages>7</tpages></addata></record>
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issn 0174-1551
1432-086X
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source MEDLINE; SpringerNature Journals
subjects Adult
Aged
Aged, 80 and over
Arterial Interventions
Arthralgia - etiology
Arthralgia - therapy
Arthritis
Biocompatibility
BIOMEDICAL RADIOGRAPHY
Body mass
Body mass index
Body size
BONE JOINTS
Cardiology
Chronic pain
Chronic Pain - etiology
Chronic Pain - therapy
Clinical Investigation
Clinical outcomes
Embolization, Therapeutic - methods
Female
Follow-Up Studies
Humans
Imaging
Imipenem
Knee
Male
Medicine
Medicine & Public Health
Middle Aged
Nuclear Medicine
Osteoarthritis
Osteoarthritis, Knee - complications
Osteoarthritis, Knee - therapy
PAIN
PATIENTS
Radiology
RADIOLOGY AND NUCLEAR MEDICINE
Retrospective Studies
Severity of Illness Index
SKELETAL DISEASES
Sodium
Statistical analysis
Treatment Outcome
Ultrasound
title Clinical Outcomes of Transcatheter Arterial Embolisation for Chronic Knee Pain: Mild-to-Moderate Versus Severe Knee Osteoarthritis
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