Investigating the Possible Protective Role of Direct Intra-arterial Administration of Mannitol and N-Acetylcysteine and Per Os Administration of Simvastatin Against Contrast-Induced Nephropathy: An Experimental Study in a Rabbit Model
Purpose Contrast-induced nephropathy (CIN) is one of the leading causes of hospital-acquired acute kidney injury due to the use of iodinated contrast media in various interventional procedures like endovascular aneurysm repair. Its pathophysiology remains mostly unclear. The purpose of the present s...
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| Veröffentlicht in: | Cardiovascular and interventional radiology 2019-12, Vol.42 (12), p.1777-1785 |
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| creator | Kalogirou, Thomas E. Meditskou, Soultana Davidopoulou, Sotiria Savvas, Ioannis Pitoulias, Apostolos G. Pitoulias, Georgios A. |
| description | Purpose
Contrast-induced nephropathy (CIN) is one of the leading causes of hospital-acquired acute kidney injury due to the use of iodinated contrast media in various interventional procedures like endovascular aneurysm repair. Its pathophysiology remains mostly unclear. The purpose of the present study was to comparatively study the possible protective role of direct intra-arterial administration of mannitol and acetylcysteine and per os administration of simvastatin in a histopathological level.
Materials and Methods
In the present study, we administered iopromide directly in the infrarenal aorta of 24 New Zealand white rabbits after laparotomy. Animals were divided in four groups of six: G1 received iopromide with no protection, G2 iopromide with mannitol, G3 iopromide with acetylcysteine, and G4 iopromide with simvastatin. Renal function blood parameters were assessed prior to the administration, and in 48 h; histopathological evaluation of the kidneys was performed.
Results
CIN was evident only in the no protection group G1. Moreover, G1 demonstrated significantly more severe lesions than groups G2, G3, and G4 regarding histopathological findings in glomeruli, vacuolization of tubular epithelial cells, tubular proteinaceous casts, and tubular necrosis. According to our results, intra-arterial administration of mannitol seems to be effective in protection against tubular necrosis.
Conclusion
In general, all three agents demonstrated a protective role in preventing the development of CIN, although it seems that there are various pathways that remain to be investigated further. |
| doi_str_mv | 10.1007/s00270-019-02304-8 |
| format | Article |
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Contrast-induced nephropathy (CIN) is one of the leading causes of hospital-acquired acute kidney injury due to the use of iodinated contrast media in various interventional procedures like endovascular aneurysm repair. Its pathophysiology remains mostly unclear. The purpose of the present study was to comparatively study the possible protective role of direct intra-arterial administration of mannitol and acetylcysteine and per os administration of simvastatin in a histopathological level.
Materials and Methods
In the present study, we administered iopromide directly in the infrarenal aorta of 24 New Zealand white rabbits after laparotomy. Animals were divided in four groups of six: G1 received iopromide with no protection, G2 iopromide with mannitol, G3 iopromide with acetylcysteine, and G4 iopromide with simvastatin. Renal function blood parameters were assessed prior to the administration, and in 48 h; histopathological evaluation of the kidneys was performed.
Results
CIN was evident only in the no protection group G1. Moreover, G1 demonstrated significantly more severe lesions than groups G2, G3, and G4 regarding histopathological findings in glomeruli, vacuolization of tubular epithelial cells, tubular proteinaceous casts, and tubular necrosis. According to our results, intra-arterial administration of mannitol seems to be effective in protection against tubular necrosis.
Conclusion
In general, all three agents demonstrated a protective role in preventing the development of CIN, although it seems that there are various pathways that remain to be investigated further.</description><identifier>ISSN: 0174-1551</identifier><identifier>EISSN: 1432-086X</identifier><identifier>DOI: 10.1007/s00270-019-02304-8</identifier><identifier>PMID: 31392490</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acetylcysteine ; Acetylcysteine - administration & dosage ; Acetylcysteine - therapeutic use ; Acute Kidney Injury - chemically induced ; Acute Kidney Injury - drug therapy ; Administration, Oral ; Animals ; AORTA ; BLOOD ; Cardiology ; Cardiovascular system ; CONTRAST MEDIA ; Contrast Media - adverse effects ; Disease Models, Animal ; Diuretics, Osmotic - administration & dosage ; Diuretics, Osmotic - therapeutic use ; Epithelial cells ; EVALUATION ; GLOMERULI ; HOSPITALS ; Humans ; Imaging ; Infusions, Intra-Arterial ; INJURIES ; Iohexol - adverse effects ; Iohexol - analogs & derivatives ; Kidneys ; Laboratory Investigation ; Lesions ; Male ; Mannitol ; Mannitol - administration & dosage ; Mannitol - therapeutic use ; Medicine ; Medicine & Public Health ; NECROSIS ; Nephropathy ; NEW ZEALAND ; Nuclear Medicine ; Other ; RABBITS ; Radiology ; RADIOLOGY AND NUCLEAR MEDICINE ; Renal function ; SAFETY ; Simvastatin ; Simvastatin - pharmacology ; Ultrasound</subject><ispartof>Cardiovascular and interventional radiology, 2019-12, Vol.42 (12), p.1777-1785</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2019</rights><rights>CardioVascular and Interventional Radiology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-35b889bc12c0587059941683619f24a05403479ded44f72c9648d9d4a070d2b13</citedby><cites>FETCH-LOGICAL-c403t-35b889bc12c0587059941683619f24a05403479ded44f72c9648d9d4a070d2b13</cites><orcidid>0000-0001-7541-832X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00270-019-02304-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00270-019-02304-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31392490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22970387$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Kalogirou, Thomas E.</creatorcontrib><creatorcontrib>Meditskou, Soultana</creatorcontrib><creatorcontrib>Davidopoulou, Sotiria</creatorcontrib><creatorcontrib>Savvas, Ioannis</creatorcontrib><creatorcontrib>Pitoulias, Apostolos G.</creatorcontrib><creatorcontrib>Pitoulias, Georgios A.</creatorcontrib><title>Investigating the Possible Protective Role of Direct Intra-arterial Administration of Mannitol and N-Acetylcysteine and Per Os Administration of Simvastatin Against Contrast-Induced Nephropathy: An Experimental Study in a Rabbit Model</title><title>Cardiovascular and interventional radiology</title><addtitle>Cardiovasc Intervent Radiol</addtitle><addtitle>Cardiovasc Intervent Radiol</addtitle><description>Purpose
Contrast-induced nephropathy (CIN) is one of the leading causes of hospital-acquired acute kidney injury due to the use of iodinated contrast media in various interventional procedures like endovascular aneurysm repair. Its pathophysiology remains mostly unclear. The purpose of the present study was to comparatively study the possible protective role of direct intra-arterial administration of mannitol and acetylcysteine and per os administration of simvastatin in a histopathological level.
Materials and Methods
In the present study, we administered iopromide directly in the infrarenal aorta of 24 New Zealand white rabbits after laparotomy. Animals were divided in four groups of six: G1 received iopromide with no protection, G2 iopromide with mannitol, G3 iopromide with acetylcysteine, and G4 iopromide with simvastatin. Renal function blood parameters were assessed prior to the administration, and in 48 h; histopathological evaluation of the kidneys was performed.
Results
CIN was evident only in the no protection group G1. Moreover, G1 demonstrated significantly more severe lesions than groups G2, G3, and G4 regarding histopathological findings in glomeruli, vacuolization of tubular epithelial cells, tubular proteinaceous casts, and tubular necrosis. According to our results, intra-arterial administration of mannitol seems to be effective in protection against tubular necrosis.
Conclusion
In general, all three agents demonstrated a protective role in preventing the development of CIN, although it seems that there are various pathways that remain to be investigated further.</description><subject>Acetylcysteine</subject><subject>Acetylcysteine - administration & dosage</subject><subject>Acetylcysteine - therapeutic use</subject><subject>Acute Kidney Injury - chemically induced</subject><subject>Acute Kidney Injury - drug therapy</subject><subject>Administration, Oral</subject><subject>Animals</subject><subject>AORTA</subject><subject>BLOOD</subject><subject>Cardiology</subject><subject>Cardiovascular system</subject><subject>CONTRAST MEDIA</subject><subject>Contrast Media - adverse effects</subject><subject>Disease Models, Animal</subject><subject>Diuretics, Osmotic - administration & dosage</subject><subject>Diuretics, Osmotic - therapeutic use</subject><subject>Epithelial cells</subject><subject>EVALUATION</subject><subject>GLOMERULI</subject><subject>HOSPITALS</subject><subject>Humans</subject><subject>Imaging</subject><subject>Infusions, Intra-Arterial</subject><subject>INJURIES</subject><subject>Iohexol - adverse effects</subject><subject>Iohexol - analogs & derivatives</subject><subject>Kidneys</subject><subject>Laboratory Investigation</subject><subject>Lesions</subject><subject>Male</subject><subject>Mannitol</subject><subject>Mannitol - administration & dosage</subject><subject>Mannitol - therapeutic use</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>NECROSIS</subject><subject>Nephropathy</subject><subject>NEW ZEALAND</subject><subject>Nuclear Medicine</subject><subject>Other</subject><subject>RABBITS</subject><subject>Radiology</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Renal function</subject><subject>SAFETY</subject><subject>Simvastatin</subject><subject>Simvastatin - pharmacology</subject><subject>Ultrasound</subject><issn>0174-1551</issn><issn>1432-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9ksFuEzEQhlcIREvhBTggS1y4GMZeb9bmFoUCkVpatSBxW3ltJ3G1sVPbG5FX5imYNKW9IE62x9_8Mx7_VfWawXsG0H7IALwFCkxR4DUIKp9Ux0zUnIKc_HxaHQNrBWVNw46qFznfALBG8uZ5dVSzWnGh4Lj6PQ9bl4tf6uLDkpSVI5cxZ98PuEmxOFP81pGriOe4IJ98wgiZh5I01am45PVApnbtg88YKz6GPXeuQ_AlDkQHS77RqXFlN5hdLs4Hdxe8dIlc5H-kXvv1Vuey74dMl9qHXMgs7gvmQufBjsahpNusUtzostp9JNNATn9tsJW1CwXbuS6j3RFM1-RK970v5DxaN7ysni30kN2r-_Wk-vH59PvsKz27-DKfTc-oEVAXWje9lKo3jBtoZAuNUoJNZD1hasGFhgYp0SrrrBCLlhs1EdIqizctWN6z-qR6e9CNONcuG49DXJkYAk6u41y1UMsWqXcHapPi7Yhf0K19Nm4YdHBxzAi2ACCx1KPgA3oTxxTwDUhNFOeNaCRS_ECZhB-Y3KLb4ER02nUMur1fuoNfOvRLd-eXbp_05l567NfOPqT8NQgC9QHIeBWWLj3W_o_sHx_nzYs</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Kalogirou, Thomas E.</creator><creator>Meditskou, Soultana</creator><creator>Davidopoulou, Sotiria</creator><creator>Savvas, Ioannis</creator><creator>Pitoulias, Apostolos G.</creator><creator>Pitoulias, Georgios A.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>OTOTI</scope><orcidid>https://orcid.org/0000-0001-7541-832X</orcidid></search><sort><creationdate>20191201</creationdate><title>Investigating the Possible Protective Role of Direct Intra-arterial Administration of Mannitol and N-Acetylcysteine and Per Os Administration of Simvastatin Against Contrast-Induced Nephropathy: An Experimental Study in a Rabbit Model</title><author>Kalogirou, Thomas E. ; Meditskou, Soultana ; Davidopoulou, Sotiria ; Savvas, Ioannis ; Pitoulias, Apostolos G. ; Pitoulias, Georgios A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-35b889bc12c0587059941683619f24a05403479ded44f72c9648d9d4a070d2b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acetylcysteine</topic><topic>Acetylcysteine - administration & dosage</topic><topic>Acetylcysteine - therapeutic use</topic><topic>Acute Kidney Injury - chemically induced</topic><topic>Acute Kidney Injury - drug therapy</topic><topic>Administration, Oral</topic><topic>Animals</topic><topic>AORTA</topic><topic>BLOOD</topic><topic>Cardiology</topic><topic>Cardiovascular system</topic><topic>CONTRAST MEDIA</topic><topic>Contrast Media - adverse effects</topic><topic>Disease Models, Animal</topic><topic>Diuretics, Osmotic - administration & dosage</topic><topic>Diuretics, Osmotic - therapeutic use</topic><topic>Epithelial cells</topic><topic>EVALUATION</topic><topic>GLOMERULI</topic><topic>HOSPITALS</topic><topic>Humans</topic><topic>Imaging</topic><topic>Infusions, Intra-Arterial</topic><topic>INJURIES</topic><topic>Iohexol - adverse effects</topic><topic>Iohexol - analogs & derivatives</topic><topic>Kidneys</topic><topic>Laboratory Investigation</topic><topic>Lesions</topic><topic>Male</topic><topic>Mannitol</topic><topic>Mannitol - administration & dosage</topic><topic>Mannitol - therapeutic use</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>NECROSIS</topic><topic>Nephropathy</topic><topic>NEW ZEALAND</topic><topic>Nuclear Medicine</topic><topic>Other</topic><topic>RABBITS</topic><topic>Radiology</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Renal function</topic><topic>SAFETY</topic><topic>Simvastatin</topic><topic>Simvastatin - pharmacology</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kalogirou, Thomas E.</creatorcontrib><creatorcontrib>Meditskou, Soultana</creatorcontrib><creatorcontrib>Davidopoulou, Sotiria</creatorcontrib><creatorcontrib>Savvas, Ioannis</creatorcontrib><creatorcontrib>Pitoulias, Apostolos G.</creatorcontrib><creatorcontrib>Pitoulias, Georgios A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Cardiovascular and interventional radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kalogirou, Thomas E.</au><au>Meditskou, Soultana</au><au>Davidopoulou, Sotiria</au><au>Savvas, Ioannis</au><au>Pitoulias, Apostolos G.</au><au>Pitoulias, Georgios A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigating the Possible Protective Role of Direct Intra-arterial Administration of Mannitol and N-Acetylcysteine and Per Os Administration of Simvastatin Against Contrast-Induced Nephropathy: An Experimental Study in a Rabbit Model</atitle><jtitle>Cardiovascular and interventional radiology</jtitle><stitle>Cardiovasc Intervent Radiol</stitle><addtitle>Cardiovasc Intervent Radiol</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>42</volume><issue>12</issue><spage>1777</spage><epage>1785</epage><pages>1777-1785</pages><issn>0174-1551</issn><eissn>1432-086X</eissn><abstract>Purpose
Contrast-induced nephropathy (CIN) is one of the leading causes of hospital-acquired acute kidney injury due to the use of iodinated contrast media in various interventional procedures like endovascular aneurysm repair. Its pathophysiology remains mostly unclear. The purpose of the present study was to comparatively study the possible protective role of direct intra-arterial administration of mannitol and acetylcysteine and per os administration of simvastatin in a histopathological level.
Materials and Methods
In the present study, we administered iopromide directly in the infrarenal aorta of 24 New Zealand white rabbits after laparotomy. Animals were divided in four groups of six: G1 received iopromide with no protection, G2 iopromide with mannitol, G3 iopromide with acetylcysteine, and G4 iopromide with simvastatin. Renal function blood parameters were assessed prior to the administration, and in 48 h; histopathological evaluation of the kidneys was performed.
Results
CIN was evident only in the no protection group G1. Moreover, G1 demonstrated significantly more severe lesions than groups G2, G3, and G4 regarding histopathological findings in glomeruli, vacuolization of tubular epithelial cells, tubular proteinaceous casts, and tubular necrosis. According to our results, intra-arterial administration of mannitol seems to be effective in protection against tubular necrosis.
Conclusion
In general, all three agents demonstrated a protective role in preventing the development of CIN, although it seems that there are various pathways that remain to be investigated further.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31392490</pmid><doi>10.1007/s00270-019-02304-8</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7541-832X</orcidid></addata></record> |
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| ispartof | Cardiovascular and interventional radiology, 2019-12, Vol.42 (12), p.1777-1785 |
| issn | 0174-1551 1432-086X |
| language | eng |
| recordid | cdi_osti_scitechconnect_22970387 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acetylcysteine Acetylcysteine - administration & dosage Acetylcysteine - therapeutic use Acute Kidney Injury - chemically induced Acute Kidney Injury - drug therapy Administration, Oral Animals AORTA BLOOD Cardiology Cardiovascular system CONTRAST MEDIA Contrast Media - adverse effects Disease Models, Animal Diuretics, Osmotic - administration & dosage Diuretics, Osmotic - therapeutic use Epithelial cells EVALUATION GLOMERULI HOSPITALS Humans Imaging Infusions, Intra-Arterial INJURIES Iohexol - adverse effects Iohexol - analogs & derivatives Kidneys Laboratory Investigation Lesions Male Mannitol Mannitol - administration & dosage Mannitol - therapeutic use Medicine Medicine & Public Health NECROSIS Nephropathy NEW ZEALAND Nuclear Medicine Other RABBITS Radiology RADIOLOGY AND NUCLEAR MEDICINE Renal function SAFETY Simvastatin Simvastatin - pharmacology Ultrasound |
| title | Investigating the Possible Protective Role of Direct Intra-arterial Administration of Mannitol and N-Acetylcysteine and Per Os Administration of Simvastatin Against Contrast-Induced Nephropathy: An Experimental Study in a Rabbit Model |
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