Disposable Biosensor Based on Amidase/CeO2/GNR Modified Inkjet‐printed CNT Electrodes‐droplet Based Paracetamol Detection in Biological Fluids for “Point‐of‐care” Applications
A disposable acetaminophen biosensor based on inkjet‐printed CNT electrodes (IJPCNT) modified with amidase/cerium dioxide@graphene nanoribbons composite was developed (ACeO2@GNR/IJPCNT). The enzyme amidase A was used for the first time as a recognition element. Inkjet‐printed CNT electrodes served a...
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| Veröffentlicht in: | Electroanalysis (New York, N.Y.) N.Y.), 2019-08, Vol.31 (8), p.1534-1542 |
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| container_title | Electroanalysis (New York, N.Y.) |
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| creator | Stanković, Dalibor M. Ognjanović, Miloš Jović, Milica Cuplić, Valentina Lesch, Andreas Girault, Hubert H. Gavrović Jankulović, Marija Antić, Bratislav |
| description | A disposable acetaminophen biosensor based on inkjet‐printed CNT electrodes (IJPCNT) modified with amidase/cerium dioxide@graphene nanoribbons composite was developed (ACeO2@GNR/IJPCNT). The enzyme amidase A was used for the first time as a recognition element. Inkjet‐printed CNT electrodes served as a basis for the construction of a biosensor that enables droplet detection using 5 μL sample volume. The biosensor showed high selectivity, sensitivity, a low detection limit of 0.18 μM and a wide working linear range from 1 to 100 μM. The proposed approach allows fast and reliable detection of acetaminophen in biological fluids with negligible matrix effect and remarkable reproducibility. |
| doi_str_mv | 10.1002/elan.201900129 |
| format | Article |
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The enzyme amidase A was used for the first time as a recognition element. Inkjet‐printed CNT electrodes served as a basis for the construction of a biosensor that enables droplet detection using 5 μL sample volume. The biosensor showed high selectivity, sensitivity, a low detection limit of 0.18 μM and a wide working linear range from 1 to 100 μM. The proposed approach allows fast and reliable detection of acetaminophen in biological fluids with negligible matrix effect and remarkable reproducibility.</description><identifier>ISSN: 1040-0397</identifier><identifier>EISSN: 1521-4109</identifier><identifier>DOI: 10.1002/elan.201900129</identifier><language>eng</language><publisher>United States</publisher><subject>60 APPLIED LIFE SCIENCES ; acetaminophen ; amidase ; AMIDASES ; BASES ; biosensor ; BODY FLUIDS ; CARBON MONOXIDE ; cerium dioxide/graphene nanoribbons composite ; CERIUM OXIDES ; DETECTION ; DROPLETS ; ELECTRODES ; GRAPHENE ; inkjet-printed sensors ; INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY</subject><ispartof>Electroanalysis (New York, N.Y.), 2019-08, Vol.31 (8), p.1534-1542</ispartof><rights>2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3549-d6e980576cb941053bd76155a427d01a35c473f3ab29df0e8f2a036edc67f7d33</citedby><cites>FETCH-LOGICAL-c3549-d6e980576cb941053bd76155a427d01a35c473f3ab29df0e8f2a036edc67f7d33</cites><orcidid>0000-0001-7465-1373</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Felan.201900129$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Felan.201900129$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.osti.gov/biblio/22946900$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Stanković, Dalibor M.</creatorcontrib><creatorcontrib>Ognjanović, Miloš</creatorcontrib><creatorcontrib>Jović, Milica</creatorcontrib><creatorcontrib>Cuplić, Valentina</creatorcontrib><creatorcontrib>Lesch, Andreas</creatorcontrib><creatorcontrib>Girault, Hubert H.</creatorcontrib><creatorcontrib>Gavrović Jankulović, Marija</creatorcontrib><creatorcontrib>Antić, Bratislav</creatorcontrib><title>Disposable Biosensor Based on Amidase/CeO2/GNR Modified Inkjet‐printed CNT Electrodes‐droplet Based Paracetamol Detection in Biological Fluids for “Point‐of‐care” Applications</title><title>Electroanalysis (New York, N.Y.)</title><description>A disposable acetaminophen biosensor based on inkjet‐printed CNT electrodes (IJPCNT) modified with amidase/cerium dioxide@graphene nanoribbons composite was developed (ACeO2@GNR/IJPCNT). The enzyme amidase A was used for the first time as a recognition element. Inkjet‐printed CNT electrodes served as a basis for the construction of a biosensor that enables droplet detection using 5 μL sample volume. The biosensor showed high selectivity, sensitivity, a low detection limit of 0.18 μM and a wide working linear range from 1 to 100 μM. The proposed approach allows fast and reliable detection of acetaminophen in biological fluids with negligible matrix effect and remarkable reproducibility.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>acetaminophen</subject><subject>amidase</subject><subject>AMIDASES</subject><subject>BASES</subject><subject>biosensor</subject><subject>BODY FLUIDS</subject><subject>CARBON MONOXIDE</subject><subject>cerium dioxide/graphene nanoribbons composite</subject><subject>CERIUM OXIDES</subject><subject>DETECTION</subject><subject>DROPLETS</subject><subject>ELECTRODES</subject><subject>GRAPHENE</subject><subject>inkjet-printed sensors</subject><subject>INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY</subject><issn>1040-0397</issn><issn>1521-4109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFUU1PGzEQXVWtVAq99myp503G9n7gYwiBIoWAEJxXjj1uTZ31yt6q4paf0B_Q_pL-m_ySThQEx17skee9N-P3iuIThwkHEFMMup8I4AqAC_WmOOK14GXFQb2lGiooQar2ffEh50cAUE2ljoq_5z4PMet1QHbmY8Y-x8TOdEbLYs9mG2-pns7xRkwvV3fsOlrvPDWv-u-POO62v4bk-5Ee5qt7tghoxhQtZmrYFIeA47PYrU7a4Kg3MbBzHAnnSd_3-6khfvVGB3YRfnibmaMNdtvft5GESSc6OoxOuNv-YbNhCITdk_NJ8c7pkPHj831cPFws7udfyuXN5dV8tiyNrCtV2gbVKdRtY9aK3Kjl2rYNr2tdidYC17I2VSud1GuhrAM8dUKDbNCapnWtlfK4-HzQjXn0XTaetv9mYt_TJzohVNWQ5YSaHFAmxZwTuo6c2ej01HHo9gF1-4C6l4CIoA6Enz7g03_Q3WI5W71y_wH-IZzr</recordid><startdate>201908</startdate><enddate>201908</enddate><creator>Stanković, Dalibor M.</creator><creator>Ognjanović, Miloš</creator><creator>Jović, Milica</creator><creator>Cuplić, Valentina</creator><creator>Lesch, Andreas</creator><creator>Girault, Hubert H.</creator><creator>Gavrović Jankulović, Marija</creator><creator>Antić, Bratislav</creator><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope><orcidid>https://orcid.org/0000-0001-7465-1373</orcidid></search><sort><creationdate>201908</creationdate><title>Disposable Biosensor Based on Amidase/CeO2/GNR Modified Inkjet‐printed CNT Electrodes‐droplet Based Paracetamol Detection in Biological Fluids for “Point‐of‐care” Applications</title><author>Stanković, Dalibor M. ; Ognjanović, Miloš ; Jović, Milica ; Cuplić, Valentina ; Lesch, Andreas ; Girault, Hubert H. ; Gavrović Jankulović, Marija ; Antić, Bratislav</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3549-d6e980576cb941053bd76155a427d01a35c473f3ab29df0e8f2a036edc67f7d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>60 APPLIED LIFE SCIENCES</topic><topic>acetaminophen</topic><topic>amidase</topic><topic>AMIDASES</topic><topic>BASES</topic><topic>biosensor</topic><topic>BODY FLUIDS</topic><topic>CARBON MONOXIDE</topic><topic>cerium dioxide/graphene nanoribbons composite</topic><topic>CERIUM OXIDES</topic><topic>DETECTION</topic><topic>DROPLETS</topic><topic>ELECTRODES</topic><topic>GRAPHENE</topic><topic>inkjet-printed sensors</topic><topic>INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stanković, Dalibor M.</creatorcontrib><creatorcontrib>Ognjanović, Miloš</creatorcontrib><creatorcontrib>Jović, Milica</creatorcontrib><creatorcontrib>Cuplić, Valentina</creatorcontrib><creatorcontrib>Lesch, Andreas</creatorcontrib><creatorcontrib>Girault, Hubert H.</creatorcontrib><creatorcontrib>Gavrović Jankulović, Marija</creatorcontrib><creatorcontrib>Antić, Bratislav</creatorcontrib><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Electroanalysis (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stanković, Dalibor M.</au><au>Ognjanović, Miloš</au><au>Jović, Milica</au><au>Cuplić, Valentina</au><au>Lesch, Andreas</au><au>Girault, Hubert H.</au><au>Gavrović Jankulović, Marija</au><au>Antić, Bratislav</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disposable Biosensor Based on Amidase/CeO2/GNR Modified Inkjet‐printed CNT Electrodes‐droplet Based Paracetamol Detection in Biological Fluids for “Point‐of‐care” Applications</atitle><jtitle>Electroanalysis (New York, N.Y.)</jtitle><date>2019-08</date><risdate>2019</risdate><volume>31</volume><issue>8</issue><spage>1534</spage><epage>1542</epage><pages>1534-1542</pages><issn>1040-0397</issn><eissn>1521-4109</eissn><abstract>A disposable acetaminophen biosensor based on inkjet‐printed CNT electrodes (IJPCNT) modified with amidase/cerium dioxide@graphene nanoribbons composite was developed (ACeO2@GNR/IJPCNT). The enzyme amidase A was used for the first time as a recognition element. Inkjet‐printed CNT electrodes served as a basis for the construction of a biosensor that enables droplet detection using 5 μL sample volume. The biosensor showed high selectivity, sensitivity, a low detection limit of 0.18 μM and a wide working linear range from 1 to 100 μM. The proposed approach allows fast and reliable detection of acetaminophen in biological fluids with negligible matrix effect and remarkable reproducibility.</abstract><cop>United States</cop><doi>10.1002/elan.201900129</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7465-1373</orcidid></addata></record> |
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| subjects | 60 APPLIED LIFE SCIENCES acetaminophen amidase AMIDASES BASES biosensor BODY FLUIDS CARBON MONOXIDE cerium dioxide/graphene nanoribbons composite CERIUM OXIDES DETECTION DROPLETS ELECTRODES GRAPHENE inkjet-printed sensors INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY |
| title | Disposable Biosensor Based on Amidase/CeO2/GNR Modified Inkjet‐printed CNT Electrodes‐droplet Based Paracetamol Detection in Biological Fluids for “Point‐of‐care” Applications |
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