Design, synthesis, and antihypertensive activity of new pyrimidine derivatives endowing new pharmacophores

A new series of achiral pyrimidine derivatives based on nifedipine-like structure was designed and synthesized. These pyrimidyl derivatives contained hydrazine, hydrazones, acetohydrazide, differently substituted benzylidene functionalities, benzosulfohydrazine, various heterocycles such as pyrazole...

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Veröffentlicht in:	Medicinal chemistry research 2019-03, Vol.28 (3), p.360-379
Hauptverfasser:	Farghaly, Ahmed M., AboulWafa, Omaima M., Elshaier, Yaseen A. M., Badawi, Waleed A., Haridy, Haridy H., Mubarak, Heba A. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Antihypertensives AORTA Biochemistry Biomedical and Life Sciences Biomedicine BLOOD PRESSURE CALCIUM Calcium compounds Cell Biology Coronary vessels Derivatives ENDOTHELIUM HEART Heart rate HYDRAZINE Hydrazines HYDRAZONES Nifedipine NITRIC OXIDE Nitric-oxide synthase Original Research Pharmacology Pharmacology/Toxicology Pharmacophores Pyrazole PYRAZOLES PYRIMIDINES RABBITS RATS Thiazoline
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