New histone deacetylase inhibitors and anticancer agents from Curcuma longa

The aims of this study were to explore histone deacetylase inhibitory and antioxidant activities of curcuminoids as well as derivatives of curcumin. Curcumin ( 6 ), demethoxycurcumin ( 7 ), dihydrocurcumin ( 8 ), bisdemethoxycurcumin ( 9 ), and hydroxycurcumin ( 10 ) were isolated and tested against...

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Veröffentlicht in:	Medicinal chemistry research 2019-10, Vol.28 (10), p.1773-1782
Hauptverfasser:	Kumboonma, Pakit, Senawong, Thanaset, Saenglee, Somprasong, Senawong, Gulsiri, Somsakeesit, La-or, Yenjai, Chavi, Phaosiri, Chanokbhorn
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Anticancer properties ANTIOXIDANTS Antitumor agents Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Cancer Cell Biology Cervical cancer Cervix Colon Colon cancer CURCUMIN Derivatives HELA CELLS Histone deacetylase Histones LARGE INTESTINE Molecular docking NEOPLASMS Original Research Pharmacology/Toxicology Selective binding TOXICITY Tumor cell lines
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