Synthesis of dehydro-α-lapachones, α- and β-lapachones, and screening against cancer cell lines
14 new naphthoquinones were prepared and tested against human cancer cell lines PC-3 (prostate), HCT-116 (colon carcinoma), SNB-19 (glioblastoma), HL-60 (leukemia) and MCF-7 (breast), and a nontumor cell line L929 (murine fibroblasts) to determine cytotoxicity with the MTT assay. 8-OH-β-lapachones (...
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| Veröffentlicht in: | Medicinal chemistry research 2019-12, Vol.28 (12), p.2109-2117 |
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| container_title | Medicinal chemistry research |
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| creator | Moreira, Caroline dos S. Nicoletti, Caroline D. Pinheiro, Daniel P. de Moraes, Leonardo G. C. Futuro, Debora O. Ferreira, Vitor F. Pessoa, Claudia do Ó da Rocha, David R. |
| description | 14 new naphthoquinones were prepared and tested against human cancer cell lines PC-3 (prostate), HCT-116 (colon carcinoma), SNB-19 (glioblastoma), HL-60 (leukemia) and MCF-7 (breast), and a nontumor cell line L929 (murine fibroblasts) to determine cytotoxicity with the MTT assay. 8-OH-β-lapachones (
14a
,
14c
,
14d
) presented best results, showing low IC
50
values and high selectivity for HCT-116 and HL-60 tumor cells. |
| doi_str_mv | 10.1007/s00044-019-02439-w |
| format | Article |
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14a
,
14c
,
14d
) presented best results, showing low IC
50
values and high selectivity for HCT-116 and HL-60 tumor cells.</description><identifier>ISSN: 1054-2523</identifier><identifier>EISSN: 1554-8120</identifier><identifier>DOI: 10.1007/s00044-019-02439-w</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>60 APPLIED LIFE SCIENCES ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Biotechnology ; Breast ; CARCINOMAS ; Cell Biology ; Colon ; Cytotoxicity ; FIBROBLASTS ; Glioblastoma ; GLIOMAS ; LARGE INTESTINE ; LEUKEMIA ; MAMMARY GLANDS ; Original Research ; Pharmacology/Toxicology ; PROSTATE ; Prostate cancer ; Selectivity ; SYNTHESIS ; TOXICITY ; Tumor cell lines ; TUMOR CELLS</subject><ispartof>Medicinal chemistry research, 2019-12, Vol.28 (12), p.2109-2117</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>Copyright Springer Nature B.V. 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-466cf369f711d51d285ceca11c8984d20e104d6ffa6d5341e7eca8af1b29a2683</citedby><cites>FETCH-LOGICAL-c347t-466cf369f711d51d285ceca11c8984d20e104d6ffa6d5341e7eca8af1b29a2683</cites><orcidid>0000-0003-4357-1092</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00044-019-02439-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00044-019-02439-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.osti.gov/biblio/22936157$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Moreira, Caroline dos S.</creatorcontrib><creatorcontrib>Nicoletti, Caroline D.</creatorcontrib><creatorcontrib>Pinheiro, Daniel P.</creatorcontrib><creatorcontrib>de Moraes, Leonardo G. C.</creatorcontrib><creatorcontrib>Futuro, Debora O.</creatorcontrib><creatorcontrib>Ferreira, Vitor F.</creatorcontrib><creatorcontrib>Pessoa, Claudia do Ó</creatorcontrib><creatorcontrib>da Rocha, David R.</creatorcontrib><title>Synthesis of dehydro-α-lapachones, α- and β-lapachones, and screening against cancer cell lines</title><title>Medicinal chemistry research</title><addtitle>Med Chem Res</addtitle><description>14 new naphthoquinones were prepared and tested against human cancer cell lines PC-3 (prostate), HCT-116 (colon carcinoma), SNB-19 (glioblastoma), HL-60 (leukemia) and MCF-7 (breast), and a nontumor cell line L929 (murine fibroblasts) to determine cytotoxicity with the MTT assay. 8-OH-β-lapachones (
14a
,
14c
,
14d
) presented best results, showing low IC
50
values and high selectivity for HCT-116 and HL-60 tumor cells.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Breast</subject><subject>CARCINOMAS</subject><subject>Cell Biology</subject><subject>Colon</subject><subject>Cytotoxicity</subject><subject>FIBROBLASTS</subject><subject>Glioblastoma</subject><subject>GLIOMAS</subject><subject>LARGE INTESTINE</subject><subject>LEUKEMIA</subject><subject>MAMMARY GLANDS</subject><subject>Original Research</subject><subject>Pharmacology/Toxicology</subject><subject>PROSTATE</subject><subject>Prostate cancer</subject><subject>Selectivity</subject><subject>SYNTHESIS</subject><subject>TOXICITY</subject><subject>Tumor cell lines</subject><subject>TUMOR CELLS</subject><issn>1054-2523</issn><issn>1554-8120</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKAzEUhoMoWKsv4Crg1ujJbS5LKd6g4EJdhzTJdKaMSU2mSB9LH6TPZGqF4sbVuf3_z-FD6JzCFQUorxMACEGA1gSY4DX5OEAjKqUgFWVwmHvIPZOMH6OTlBYAvAQhR2j2vPZD61KXcGiwde3axkA2n6TXS23a4F26xHnE2lu8-fqz3q6Sic75zs-xnuvOpwEb7Y2L2Li-x32XhafoqNF9cme_dYxe725fJg9k-nT_OLmZEsNFORBRFKbhRd2UlFpJLaukcUZTaqq6EpaBoyBs0TS6sJIL6sp8rXRDZ6zWrKj4GF3sckMaOpVMNzjTmuC9M4NirOYFleVetYzhfeXSoBZhFX1-TDFOBSurOsMZI7ZTmRhSiq5Ry9i96bhWFNSWuNoRV5m4-iGuPrKJ70wpi_3cxX30P65vG4qFow</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Moreira, Caroline dos S.</creator><creator>Nicoletti, Caroline D.</creator><creator>Pinheiro, Daniel P.</creator><creator>de Moraes, Leonardo G. 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C.</creatorcontrib><creatorcontrib>Futuro, Debora O.</creatorcontrib><creatorcontrib>Ferreira, Vitor F.</creatorcontrib><creatorcontrib>Pessoa, Claudia do Ó</creatorcontrib><creatorcontrib>da Rocha, David R.</creatorcontrib><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>OSTI.GOV</collection><jtitle>Medicinal chemistry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moreira, Caroline dos S.</au><au>Nicoletti, Caroline D.</au><au>Pinheiro, Daniel P.</au><au>de Moraes, Leonardo G. 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14a
,
14c
,
14d
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50
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| subjects | 60 APPLIED LIFE SCIENCES Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Breast CARCINOMAS Cell Biology Colon Cytotoxicity FIBROBLASTS Glioblastoma GLIOMAS LARGE INTESTINE LEUKEMIA MAMMARY GLANDS Original Research Pharmacology/Toxicology PROSTATE Prostate cancer Selectivity SYNTHESIS TOXICITY Tumor cell lines TUMOR CELLS |
| title | Synthesis of dehydro-α-lapachones, α- and β-lapachones, and screening against cancer cell lines |
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