Effect of 30-Day Hindlimb Unloading and Hypergravity on Bone Marrow Stromal Progenitors in C57Bl/6N Mice
We studied the effect of 30-day hindlimb unloading and subsequent simulated hypergravity on the cellularity and proliferative, clonogenic, and differentiation potential of bone marrow stromal progenitors in mice. Clonogenic and differentiation activity of stromal cells decreased after unloading; pro...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2018-11, Vol.166 (1), p.130-134 |
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| creator | Markina, E. A. Andrianova, I. V. Shtemberg, A. S. Buravkova, L. B. |
| description | We studied the effect of 30-day hindlimb unloading and subsequent simulated hypergravity on the cellularity and proliferative, clonogenic, and differentiation potential of bone marrow stromal progenitors in mice. Clonogenic and differentiation activity of stromal cells decreased after unloading; proliferative and differentiation activity of bone marrow stromal progenitors increased after hypergravity simulation. Our findings demonstrated negative effect of unloading on functional activity of mouse bone marrow stromal progenitors. Short-term hypergravity after unloading produced a stimulating effect on the bone marrow stromal progenitors. |
| doi_str_mv | 10.1007/s10517-018-4301-9 |
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A.</creatorcontrib><creatorcontrib>Andrianova, I. V.</creatorcontrib><creatorcontrib>Shtemberg, A. S.</creatorcontrib><creatorcontrib>Buravkova, L. B.</creatorcontrib><title>Effect of 30-Day Hindlimb Unloading and Hypergravity on Bone Marrow Stromal Progenitors in C57Bl/6N Mice</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>We studied the effect of 30-day hindlimb unloading and subsequent simulated hypergravity on the cellularity and proliferative, clonogenic, and differentiation potential of bone marrow stromal progenitors in mice. Clonogenic and differentiation activity of stromal cells decreased after unloading; proliferative and differentiation activity of bone marrow stromal progenitors increased after hypergravity simulation. Our findings demonstrated negative effect of unloading on functional activity of mouse bone marrow stromal progenitors. 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Clonogenic and differentiation activity of stromal cells decreased after unloading; proliferative and differentiation activity of bone marrow stromal progenitors increased after hypergravity simulation. Our findings demonstrated negative effect of unloading on functional activity of mouse bone marrow stromal progenitors. Short-term hypergravity after unloading produced a stimulating effect on the bone marrow stromal progenitors.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30417292</pmid><doi>10.1007/s10517-018-4301-9</doi><tpages>5</tpages></addata></record> |
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| subjects | 60 APPLIED LIFE SCIENCES Animals Biomedical and Life Sciences Biomedicine BONE MARROW Bone Marrow Cells - cytology Bone Marrow Cells - metabolism Cell Biology Cell Differentiation - physiology Cell Proliferation - physiology Hindlimb Suspension - methods Hypergravity Internal Medicine Laboratory Medicine Male MICE Osteoprogenitor cells Pathology Rodents SIMULATION Stem Cells - cytology Stem Cells - metabolism Stromal cells Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine) Unloading |
| title | Effect of 30-Day Hindlimb Unloading and Hypergravity on Bone Marrow Stromal Progenitors in C57Bl/6N Mice |
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