The Sentinel Lymph Node Biopsy Using Indocyanine Green Fluorescence Plus Radioisotope Method Compared With the Radioisotope-Only Method for Breast Cancer Patients After Neoadjuvant Chemotherapy: A Prospective, Randomized, Open-Label, Single-Center Phase 2 Trial
Background This study aimed to compare the sentinel lymph node (SLN) identification rates for breast cancer patients after neoadjuvant chemotherapy (NAC) between the dual method (DM) of indocyanine green fluorescence (ICG-F) plus a radioisotope (RI) and RI alone. Methods This randomized study enroll...
Gespeichert in:
| Veröffentlicht in: | Annals of surgical oncology 2019-08, Vol.26 (8), p.2409-2416 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2416 |
|---|---|
| container_issue | 8 |
| container_start_page | 2409 |
| container_title | Annals of surgical oncology |
| container_volume | 26 |
| creator | Jung, So-Youn Han, Jai Hong Park, Soo Jin Lee, Eun-Gyeong Kwak, Joohwa Kim, Sun Hye Lee, Moo Hyun Lee, Eun Sook Kang, Han-Sung Lee, Keun Seok Park, In Hae Sim, Sung Hoon Jeong, Hae Jeong Kwon, Youngmee Lee, Dong-Eun Kim, Seok-Ki Lee, Seeyoun |
| description | Background
This study aimed to compare the sentinel lymph node (SLN) identification rates for breast cancer patients after neoadjuvant chemotherapy (NAC) between the dual method (DM) of indocyanine green fluorescence (ICG-F) plus a radioisotope (RI) and RI alone.
Methods
This randomized study enrolled 130 patients who received NAC for breast cancer and 122 patients who received SLN biopsy (SLNB) using either DM (
n
= 58) or RI only (
n
= 64). The study compared the identification rate, number of SLNs, and detection time of SLNB.
Results
Among the 122 patients, 113 (92.6%) were clinically node-positive before NAC. The SLN identification rate was 98.3% in the DM group and 93.8% in the RI group (
p
= 0.14). The DM group and the RI group were similar in the average number of SLNs (2.2 ± 1.13 vs. 1.9 ± 1.33;
p
= 0.26) and the time to detection of the first SLN (8.7 ± 4.98 vs. 8.3 ± 4.31 min;
p
= 0.30). In the DM group, transcutaneous lymphatic drainage was visualized by fluorescence imaging for 65.5% (38 of 58) of the patients. The SLN identification rate was 94.7% using ICG-F and 93% using RI (
p
= 0.79). During and after the operation, no complications, including allergic reactions or skin necrosis, occurred.
Conclusions
This study is the first randomized trial to use ICG-F for SLNB in breast cancer patients after NAC. The DM including ICG-F could be a feasible and safe method for SLNB in initially node-positive breast cancer patients with NAC. |
| doi_str_mv | 10.1245/s10434-019-07400-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_22927646</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2221101260</sourcerecordid><originalsourceid>FETCH-LOGICAL-c403t-7c0885f6f0d1c65e0449ef094efa517c9447b8d56eb0d05484b16eead87162773</originalsourceid><addsrcrecordid>eNp9kstu1DAUhgOioqXwAiyQJTYsJmAnjpN0Nx3RUmnojOhULCOPc9J4lNjBdiqFp-cM0wsrVr6c7_znoj-K3jP6mSU8--IZ5SmPKStjmnNKY_oyOmEZfnFRsFd4p6KIy0Rkx9Eb73eUsjyl2evoOMVIVmbFyYujTQvkBkzQBjqynPqhJde2BnKu7eAncuu1uSNXprZqkgYhcukADLnoRuvAKzAKyLobPfkha221t8EOQL5DaG1NFrYfpIOa_NShJQFL_UvFK9NNj2hjHTl3IH0gC4mijqxl0NiYJ_Mm4PMarKx34700SLTQW5RzcpjOyJysnfUDqKDvYYYlsNte_4Z6RlYDmHgpt9DNyA1O0kG8QM29eis9kIRsnJbd2-iokZ2Hdw_naXR78XWz-BYvV5dXi_kyVpymIc4VLYqsEQ2tmRIZUM5LaGjJoZEZy1XJeb4t6kzAltY04wXfMgEg6yJnIsnz9DT6eNC1PujKKx1Atcoag71XSVImueACqU8HanD21wg-VL3GTXedNGBHj2DKilIwwZ8Fn9CdHZ3BGZBKGKMsERSp5EAp3JN30FSD0710U8VotbdSdbBShVaq_lqp2id9eJAetz3UTymP3kEgPQAeQ-YO3HPt_8j-AUVh1ew</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2221101260</pqid></control><display><type>article</type><title>The Sentinel Lymph Node Biopsy Using Indocyanine Green Fluorescence Plus Radioisotope Method Compared With the Radioisotope-Only Method for Breast Cancer Patients After Neoadjuvant Chemotherapy: A Prospective, Randomized, Open-Label, Single-Center Phase 2 Trial</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Jung, So-Youn ; Han, Jai Hong ; Park, Soo Jin ; Lee, Eun-Gyeong ; Kwak, Joohwa ; Kim, Sun Hye ; Lee, Moo Hyun ; Lee, Eun Sook ; Kang, Han-Sung ; Lee, Keun Seok ; Park, In Hae ; Sim, Sung Hoon ; Jeong, Hae Jeong ; Kwon, Youngmee ; Lee, Dong-Eun ; Kim, Seok-Ki ; Lee, Seeyoun</creator><creatorcontrib>Jung, So-Youn ; Han, Jai Hong ; Park, Soo Jin ; Lee, Eun-Gyeong ; Kwak, Joohwa ; Kim, Sun Hye ; Lee, Moo Hyun ; Lee, Eun Sook ; Kang, Han-Sung ; Lee, Keun Seok ; Park, In Hae ; Sim, Sung Hoon ; Jeong, Hae Jeong ; Kwon, Youngmee ; Lee, Dong-Eun ; Kim, Seok-Ki ; Lee, Seeyoun</creatorcontrib><description>Background
This study aimed to compare the sentinel lymph node (SLN) identification rates for breast cancer patients after neoadjuvant chemotherapy (NAC) between the dual method (DM) of indocyanine green fluorescence (ICG-F) plus a radioisotope (RI) and RI alone.
Methods
This randomized study enrolled 130 patients who received NAC for breast cancer and 122 patients who received SLN biopsy (SLNB) using either DM (
n
= 58) or RI only (
n
= 64). The study compared the identification rate, number of SLNs, and detection time of SLNB.
Results
Among the 122 patients, 113 (92.6%) were clinically node-positive before NAC. The SLN identification rate was 98.3% in the DM group and 93.8% in the RI group (
p
= 0.14). The DM group and the RI group were similar in the average number of SLNs (2.2 ± 1.13 vs. 1.9 ± 1.33;
p
= 0.26) and the time to detection of the first SLN (8.7 ± 4.98 vs. 8.3 ± 4.31 min;
p
= 0.30). In the DM group, transcutaneous lymphatic drainage was visualized by fluorescence imaging for 65.5% (38 of 58) of the patients. The SLN identification rate was 94.7% using ICG-F and 93% using RI (
p
= 0.79). During and after the operation, no complications, including allergic reactions or skin necrosis, occurred.
Conclusions
This study is the first randomized trial to use ICG-F for SLNB in breast cancer patients after NAC. The DM including ICG-F could be a feasible and safe method for SLNB in initially node-positive breast cancer patients with NAC.</description><identifier>ISSN: 1068-9265</identifier><identifier>ISSN: 1534-4681</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-019-07400-0</identifier><identifier>PMID: 31065958</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>BIOPSY ; Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - pathology ; Breast Oncology ; Carcinoma, Ductal, Breast - drug therapy ; Carcinoma, Ductal, Breast - pathology ; Carcinoma, Lobular - drug therapy ; Carcinoma, Lobular - pathology ; CHEMOTHERAPY ; Coloring Agents ; Female ; FLUORESCENCE ; Follow-Up Studies ; Humans ; Hypersensitivity ; Identification ; INDOCYANINE GREEN ; LYMPH NODES ; Lymphatic drainage ; Lymphatic system ; MAMMARY GLANDS ; Medicine ; Medicine & Public Health ; Middle Aged ; Multimodal Imaging - methods ; NECROSIS ; Neoadjuvant Therapy ; NEOPLASMS ; Oncology ; PATIENTS ; Prognosis ; Prospective Studies ; Radioisotopes ; RADIOLOGY AND NUCLEAR MEDICINE ; Radiopharmaceuticals ; Sentinel Lymph Node - pathology ; Sentinel Lymph Node - surgery ; Sentinel Lymph Node Biopsy - methods ; SKIN ; Surgery ; Surgical Oncology</subject><ispartof>Annals of surgical oncology, 2019-08, Vol.26 (8), p.2409-2416</ispartof><rights>Society of Surgical Oncology 2019</rights><rights>Annals of Surgical Oncology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-7c0885f6f0d1c65e0449ef094efa517c9447b8d56eb0d05484b16eead87162773</citedby><cites>FETCH-LOGICAL-c403t-7c0885f6f0d1c65e0449ef094efa517c9447b8d56eb0d05484b16eead87162773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-019-07400-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-019-07400-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31065958$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22927646$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Jung, So-Youn</creatorcontrib><creatorcontrib>Han, Jai Hong</creatorcontrib><creatorcontrib>Park, Soo Jin</creatorcontrib><creatorcontrib>Lee, Eun-Gyeong</creatorcontrib><creatorcontrib>Kwak, Joohwa</creatorcontrib><creatorcontrib>Kim, Sun Hye</creatorcontrib><creatorcontrib>Lee, Moo Hyun</creatorcontrib><creatorcontrib>Lee, Eun Sook</creatorcontrib><creatorcontrib>Kang, Han-Sung</creatorcontrib><creatorcontrib>Lee, Keun Seok</creatorcontrib><creatorcontrib>Park, In Hae</creatorcontrib><creatorcontrib>Sim, Sung Hoon</creatorcontrib><creatorcontrib>Jeong, Hae Jeong</creatorcontrib><creatorcontrib>Kwon, Youngmee</creatorcontrib><creatorcontrib>Lee, Dong-Eun</creatorcontrib><creatorcontrib>Kim, Seok-Ki</creatorcontrib><creatorcontrib>Lee, Seeyoun</creatorcontrib><title>The Sentinel Lymph Node Biopsy Using Indocyanine Green Fluorescence Plus Radioisotope Method Compared With the Radioisotope-Only Method for Breast Cancer Patients After Neoadjuvant Chemotherapy: A Prospective, Randomized, Open-Label, Single-Center Phase 2 Trial</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
This study aimed to compare the sentinel lymph node (SLN) identification rates for breast cancer patients after neoadjuvant chemotherapy (NAC) between the dual method (DM) of indocyanine green fluorescence (ICG-F) plus a radioisotope (RI) and RI alone.
Methods
This randomized study enrolled 130 patients who received NAC for breast cancer and 122 patients who received SLN biopsy (SLNB) using either DM (
n
= 58) or RI only (
n
= 64). The study compared the identification rate, number of SLNs, and detection time of SLNB.
Results
Among the 122 patients, 113 (92.6%) were clinically node-positive before NAC. The SLN identification rate was 98.3% in the DM group and 93.8% in the RI group (
p
= 0.14). The DM group and the RI group were similar in the average number of SLNs (2.2 ± 1.13 vs. 1.9 ± 1.33;
p
= 0.26) and the time to detection of the first SLN (8.7 ± 4.98 vs. 8.3 ± 4.31 min;
p
= 0.30). In the DM group, transcutaneous lymphatic drainage was visualized by fluorescence imaging for 65.5% (38 of 58) of the patients. The SLN identification rate was 94.7% using ICG-F and 93% using RI (
p
= 0.79). During and after the operation, no complications, including allergic reactions or skin necrosis, occurred.
Conclusions
This study is the first randomized trial to use ICG-F for SLNB in breast cancer patients after NAC. The DM including ICG-F could be a feasible and safe method for SLNB in initially node-positive breast cancer patients with NAC.</description><subject>BIOPSY</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Oncology</subject><subject>Carcinoma, Ductal, Breast - drug therapy</subject><subject>Carcinoma, Ductal, Breast - pathology</subject><subject>Carcinoma, Lobular - drug therapy</subject><subject>Carcinoma, Lobular - pathology</subject><subject>CHEMOTHERAPY</subject><subject>Coloring Agents</subject><subject>Female</subject><subject>FLUORESCENCE</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hypersensitivity</subject><subject>Identification</subject><subject>INDOCYANINE GREEN</subject><subject>LYMPH NODES</subject><subject>Lymphatic drainage</subject><subject>Lymphatic system</subject><subject>MAMMARY GLANDS</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multimodal Imaging - methods</subject><subject>NECROSIS</subject><subject>Neoadjuvant Therapy</subject><subject>NEOPLASMS</subject><subject>Oncology</subject><subject>PATIENTS</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Radioisotopes</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Radiopharmaceuticals</subject><subject>Sentinel Lymph Node - pathology</subject><subject>Sentinel Lymph Node - surgery</subject><subject>Sentinel Lymph Node Biopsy - methods</subject><subject>SKIN</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><issn>1068-9265</issn><issn>1534-4681</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kstu1DAUhgOioqXwAiyQJTYsJmAnjpN0Nx3RUmnojOhULCOPc9J4lNjBdiqFp-cM0wsrVr6c7_znoj-K3jP6mSU8--IZ5SmPKStjmnNKY_oyOmEZfnFRsFd4p6KIy0Rkx9Eb73eUsjyl2evoOMVIVmbFyYujTQvkBkzQBjqynPqhJde2BnKu7eAncuu1uSNXprZqkgYhcukADLnoRuvAKzAKyLobPfkha221t8EOQL5DaG1NFrYfpIOa_NShJQFL_UvFK9NNj2hjHTl3IH0gC4mijqxl0NiYJ_Mm4PMarKx34700SLTQW5RzcpjOyJysnfUDqKDvYYYlsNte_4Z6RlYDmHgpt9DNyA1O0kG8QM29eis9kIRsnJbd2-iokZ2Hdw_naXR78XWz-BYvV5dXi_kyVpymIc4VLYqsEQ2tmRIZUM5LaGjJoZEZy1XJeb4t6kzAltY04wXfMgEg6yJnIsnz9DT6eNC1PujKKx1Atcoag71XSVImueACqU8HanD21wg-VL3GTXedNGBHj2DKilIwwZ8Fn9CdHZ3BGZBKGKMsERSp5EAp3JN30FSD0710U8VotbdSdbBShVaq_lqp2id9eJAetz3UTymP3kEgPQAeQ-YO3HPt_8j-AUVh1ew</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Jung, So-Youn</creator><creator>Han, Jai Hong</creator><creator>Park, Soo Jin</creator><creator>Lee, Eun-Gyeong</creator><creator>Kwak, Joohwa</creator><creator>Kim, Sun Hye</creator><creator>Lee, Moo Hyun</creator><creator>Lee, Eun Sook</creator><creator>Kang, Han-Sung</creator><creator>Lee, Keun Seok</creator><creator>Park, In Hae</creator><creator>Sim, Sung Hoon</creator><creator>Jeong, Hae Jeong</creator><creator>Kwon, Youngmee</creator><creator>Lee, Dong-Eun</creator><creator>Kim, Seok-Ki</creator><creator>Lee, Seeyoun</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>20190801</creationdate><title>The Sentinel Lymph Node Biopsy Using Indocyanine Green Fluorescence Plus Radioisotope Method Compared With the Radioisotope-Only Method for Breast Cancer Patients After Neoadjuvant Chemotherapy: A Prospective, Randomized, Open-Label, Single-Center Phase 2 Trial</title><author>Jung, So-Youn ; Han, Jai Hong ; Park, Soo Jin ; Lee, Eun-Gyeong ; Kwak, Joohwa ; Kim, Sun Hye ; Lee, Moo Hyun ; Lee, Eun Sook ; Kang, Han-Sung ; Lee, Keun Seok ; Park, In Hae ; Sim, Sung Hoon ; Jeong, Hae Jeong ; Kwon, Youngmee ; Lee, Dong-Eun ; Kim, Seok-Ki ; Lee, Seeyoun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-7c0885f6f0d1c65e0449ef094efa517c9447b8d56eb0d05484b16eead87162773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>BIOPSY</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Oncology</topic><topic>Carcinoma, Ductal, Breast - drug therapy</topic><topic>Carcinoma, Ductal, Breast - pathology</topic><topic>Carcinoma, Lobular - drug therapy</topic><topic>Carcinoma, Lobular - pathology</topic><topic>CHEMOTHERAPY</topic><topic>Coloring Agents</topic><topic>Female</topic><topic>FLUORESCENCE</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hypersensitivity</topic><topic>Identification</topic><topic>INDOCYANINE GREEN</topic><topic>LYMPH NODES</topic><topic>Lymphatic drainage</topic><topic>Lymphatic system</topic><topic>MAMMARY GLANDS</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multimodal Imaging - methods</topic><topic>NECROSIS</topic><topic>Neoadjuvant Therapy</topic><topic>NEOPLASMS</topic><topic>Oncology</topic><topic>PATIENTS</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Radioisotopes</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Radiopharmaceuticals</topic><topic>Sentinel Lymph Node - pathology</topic><topic>Sentinel Lymph Node - surgery</topic><topic>Sentinel Lymph Node Biopsy - methods</topic><topic>SKIN</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jung, So-Youn</creatorcontrib><creatorcontrib>Han, Jai Hong</creatorcontrib><creatorcontrib>Park, Soo Jin</creatorcontrib><creatorcontrib>Lee, Eun-Gyeong</creatorcontrib><creatorcontrib>Kwak, Joohwa</creatorcontrib><creatorcontrib>Kim, Sun Hye</creatorcontrib><creatorcontrib>Lee, Moo Hyun</creatorcontrib><creatorcontrib>Lee, Eun Sook</creatorcontrib><creatorcontrib>Kang, Han-Sung</creatorcontrib><creatorcontrib>Lee, Keun Seok</creatorcontrib><creatorcontrib>Park, In Hae</creatorcontrib><creatorcontrib>Sim, Sung Hoon</creatorcontrib><creatorcontrib>Jeong, Hae Jeong</creatorcontrib><creatorcontrib>Kwon, Youngmee</creatorcontrib><creatorcontrib>Lee, Dong-Eun</creatorcontrib><creatorcontrib>Kim, Seok-Ki</creatorcontrib><creatorcontrib>Lee, Seeyoun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jung, So-Youn</au><au>Han, Jai Hong</au><au>Park, Soo Jin</au><au>Lee, Eun-Gyeong</au><au>Kwak, Joohwa</au><au>Kim, Sun Hye</au><au>Lee, Moo Hyun</au><au>Lee, Eun Sook</au><au>Kang, Han-Sung</au><au>Lee, Keun Seok</au><au>Park, In Hae</au><au>Sim, Sung Hoon</au><au>Jeong, Hae Jeong</au><au>Kwon, Youngmee</au><au>Lee, Dong-Eun</au><au>Kim, Seok-Ki</au><au>Lee, Seeyoun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Sentinel Lymph Node Biopsy Using Indocyanine Green Fluorescence Plus Radioisotope Method Compared With the Radioisotope-Only Method for Breast Cancer Patients After Neoadjuvant Chemotherapy: A Prospective, Randomized, Open-Label, Single-Center Phase 2 Trial</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>26</volume><issue>8</issue><spage>2409</spage><epage>2416</epage><pages>2409-2416</pages><issn>1068-9265</issn><issn>1534-4681</issn><eissn>1534-4681</eissn><abstract>Background
This study aimed to compare the sentinel lymph node (SLN) identification rates for breast cancer patients after neoadjuvant chemotherapy (NAC) between the dual method (DM) of indocyanine green fluorescence (ICG-F) plus a radioisotope (RI) and RI alone.
Methods
This randomized study enrolled 130 patients who received NAC for breast cancer and 122 patients who received SLN biopsy (SLNB) using either DM (
n
= 58) or RI only (
n
= 64). The study compared the identification rate, number of SLNs, and detection time of SLNB.
Results
Among the 122 patients, 113 (92.6%) were clinically node-positive before NAC. The SLN identification rate was 98.3% in the DM group and 93.8% in the RI group (
p
= 0.14). The DM group and the RI group were similar in the average number of SLNs (2.2 ± 1.13 vs. 1.9 ± 1.33;
p
= 0.26) and the time to detection of the first SLN (8.7 ± 4.98 vs. 8.3 ± 4.31 min;
p
= 0.30). In the DM group, transcutaneous lymphatic drainage was visualized by fluorescence imaging for 65.5% (38 of 58) of the patients. The SLN identification rate was 94.7% using ICG-F and 93% using RI (
p
= 0.79). During and after the operation, no complications, including allergic reactions or skin necrosis, occurred.
Conclusions
This study is the first randomized trial to use ICG-F for SLNB in breast cancer patients after NAC. The DM including ICG-F could be a feasible and safe method for SLNB in initially node-positive breast cancer patients with NAC.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>31065958</pmid><doi>10.1245/s10434-019-07400-0</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2019-08, Vol.26 (8), p.2409-2416 |
| issn | 1068-9265 1534-4681 1534-4681 |
| language | eng |
| recordid | cdi_osti_scitechconnect_22927646 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | BIOPSY Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - pathology Breast Oncology Carcinoma, Ductal, Breast - drug therapy Carcinoma, Ductal, Breast - pathology Carcinoma, Lobular - drug therapy Carcinoma, Lobular - pathology CHEMOTHERAPY Coloring Agents Female FLUORESCENCE Follow-Up Studies Humans Hypersensitivity Identification INDOCYANINE GREEN LYMPH NODES Lymphatic drainage Lymphatic system MAMMARY GLANDS Medicine Medicine & Public Health Middle Aged Multimodal Imaging - methods NECROSIS Neoadjuvant Therapy NEOPLASMS Oncology PATIENTS Prognosis Prospective Studies Radioisotopes RADIOLOGY AND NUCLEAR MEDICINE Radiopharmaceuticals Sentinel Lymph Node - pathology Sentinel Lymph Node - surgery Sentinel Lymph Node Biopsy - methods SKIN Surgery Surgical Oncology |
| title | The Sentinel Lymph Node Biopsy Using Indocyanine Green Fluorescence Plus Radioisotope Method Compared With the Radioisotope-Only Method for Breast Cancer Patients After Neoadjuvant Chemotherapy: A Prospective, Randomized, Open-Label, Single-Center Phase 2 Trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T05%3A32%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_osti_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Sentinel%20Lymph%20Node%20Biopsy%20Using%20Indocyanine%20Green%20Fluorescence%20Plus%20Radioisotope%20Method%20Compared%20With%20the%20Radioisotope-Only%20Method%20for%20Breast%20Cancer%20Patients%20After%20Neoadjuvant%20Chemotherapy:%20A%20Prospective,%20Randomized,%20Open-Label,%20Single-Center%20Phase%202%20Trial&rft.jtitle=Annals%20of%20surgical%20oncology&rft.au=Jung,%20So-Youn&rft.date=2019-08-01&rft.volume=26&rft.issue=8&rft.spage=2409&rft.epage=2416&rft.pages=2409-2416&rft.issn=1068-9265&rft.eissn=1534-4681&rft_id=info:doi/10.1245/s10434-019-07400-0&rft_dat=%3Cproquest_osti_%3E2221101260%3C/proquest_osti_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2221101260&rft_id=info:pmid/31065958&rfr_iscdi=true |