The Ion Source of Nitrogen Direct Analysis in Real-Time Mass Spectrometry as a Highly Efficient Reactor: Generation of Reactive Oxygen Species
An innovative strategy for sustainably active oxygen capture using nitrogen (N 2 ) instead of helium (He) as direct analysis in real-time (DART) gas is demonstrated in this work. DART MS was carried out to analyze different polarity compounds including organophosphorus pesticides, amino acids, hormo...
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| Veröffentlicht in: | Journal of the American Society for Mass Spectrometry 2019-04, Vol.30 (4), p.581-587 |
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| creator | Su, Rui Yu, Wenjing Sun, Kaiju Yang, Jie Chen, Changbao Lian, Wenhui Liu, Shuying Yang, Hongmei |
| description | An innovative strategy for sustainably active oxygen capture using nitrogen (N
2
) instead of helium (He) as direct analysis in real-time (DART) gas is demonstrated in this work. DART MS was carried out to analyze different polarity compounds including organophosphorus pesticides, amino acids, hormones, and poly brominated diphenyl ethers by using He and N
2
as DART gas, respectively. The unexpectedly characteristic ionization reactions, including replacement reaction where the sulfur atom of P=S group, were replaced by oxygen atom, oxidation ([M + nO + H]
+
or [M + nO-H]
−
(
n
= 1, 2, 3, 4, 5)), and hydrogen loss (loss of two hydrogens) rapidly occurred in situ in the presence of N
2
under ambient conditions without any additives. The reaction mechanisms were proposed and further confirmed by high-resolution tandem mass spectrometry. Our study under high temperature and high voltage provides a powerful tool for generating unique ionic species that may be difficult to form by other means, which also creates favorable conditions for the future study of the mechanism of DART MS.
Graphical Abstract |
| doi_str_mv | 10.1007/s13361-019-02132-7 |
| format | Article |
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2
) instead of helium (He) as direct analysis in real-time (DART) gas is demonstrated in this work. DART MS was carried out to analyze different polarity compounds including organophosphorus pesticides, amino acids, hormones, and poly brominated diphenyl ethers by using He and N
2
as DART gas, respectively. The unexpectedly characteristic ionization reactions, including replacement reaction where the sulfur atom of P=S group, were replaced by oxygen atom, oxidation ([M + nO + H]
+
or [M + nO-H]
−
(
n
= 1, 2, 3, 4, 5)), and hydrogen loss (loss of two hydrogens) rapidly occurred in situ in the presence of N
2
under ambient conditions without any additives. The reaction mechanisms were proposed and further confirmed by high-resolution tandem mass spectrometry. Our study under high temperature and high voltage provides a powerful tool for generating unique ionic species that may be difficult to form by other means, which also creates favorable conditions for the future study of the mechanism of DART MS.
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2
) instead of helium (He) as direct analysis in real-time (DART) gas is demonstrated in this work. DART MS was carried out to analyze different polarity compounds including organophosphorus pesticides, amino acids, hormones, and poly brominated diphenyl ethers by using He and N
2
as DART gas, respectively. The unexpectedly characteristic ionization reactions, including replacement reaction where the sulfur atom of P=S group, were replaced by oxygen atom, oxidation ([M + nO + H]
+
or [M + nO-H]
−
(
n
= 1, 2, 3, 4, 5)), and hydrogen loss (loss of two hydrogens) rapidly occurred in situ in the presence of N
2
under ambient conditions without any additives. The reaction mechanisms were proposed and further confirmed by high-resolution tandem mass spectrometry. Our study under high temperature and high voltage provides a powerful tool for generating unique ionic species that may be difficult to form by other means, which also creates favorable conditions for the future study of the mechanism of DART MS.
Graphical Abstract</description><subject>Additives</subject><subject>Amino acids</subject><subject>Analytical Chemistry</subject><subject>ATOMIC AND MOLECULAR PHYSICS</subject><subject>ATOMS</subject><subject>Bioinformatics</subject><subject>Biotechnology</subject><subject>Bromination</subject><subject>CAPTURE</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Ethers</subject><subject>HELIUM</subject><subject>High temperature</subject><subject>High voltages</subject><subject>Hormones</subject><subject>HYDROGEN</subject><subject>ION SOURCES</subject><subject>IONIZATION</subject><subject>Ions</subject><subject>Mass spectrometry</subject><subject>MASS SPECTROSCOPY</subject><subject>NITROGEN</subject><subject>Organic Chemistry</subject><subject>OXIDATION</subject><subject>OXYGEN</subject><subject>Pesticides</subject><subject>PHENYL ETHER</subject><subject>Polarity</subject><subject>Proteomics</subject><subject>REACTION KINETICS</subject><subject>Reaction mechanisms</subject><subject>Reactive oxygen species</subject><subject>Real time</subject><subject>Research Article</subject><subject>Scientific imaging</subject><subject>Spectroscopy</subject><subject>SULFUR</subject><issn>1044-0305</issn><issn>1879-1123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1DAUhSMEoqXwAiyQJTZsAvfaThyzq0r_pEIlOqwtx3Mz4yqJBzuDyEv0mfF0Srvrypb9nXN07ymK9wifEUB9SShEjSWgLoGj4KV6URxio3SJyMXLfAcpSxBQHRRvUroFQAVavS4OBKhGAsjD4m6xJnYZRnYTttERCx374acYVjSybz6Sm9jxaPs5-cT8yH6S7cuFH4h9tymxm00GYhhoijOziVl24VfrfmanXeedp3HaKdwU4ld2TiNFO_mclUPun_0fYtd_513WzslTelu86myf6N3DeVT8OjtdnFyUV9fnlyfHV6WTqppK0YqaGqo1qs41ttZKK0m85UosLefQVqRbIKzEkoRF7CS2SwRNBMrpqhVHxce9b0iTN8n5idzahXHM8xjONRcgIVOf9tQmht9bSpMZfHLU93aksE2GYyNRNAqbJ8NH9DYvNG8uU6JSFdZaPE9lEwlYyR3F95SLIaVIndlEP9g4GwSza97smze5eXPfvFFZ9OHBetsOtHyU_K86A2IPpPw1rig-ZT9j-w-QwLcJ</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Su, Rui</creator><creator>Yu, Wenjing</creator><creator>Sun, Kaiju</creator><creator>Yang, Jie</creator><creator>Chen, Changbao</creator><creator>Lian, Wenhui</creator><creator>Liu, Shuying</creator><creator>Yang, Hongmei</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>20190401</creationdate><title>The Ion Source of Nitrogen Direct Analysis in Real-Time Mass Spectrometry as a Highly Efficient Reactor: Generation of Reactive Oxygen Species</title><author>Su, Rui ; Yu, Wenjing ; Sun, Kaiju ; Yang, Jie ; Chen, Changbao ; Lian, Wenhui ; Liu, Shuying ; Yang, Hongmei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-3b36e8e6917fc8a697974e2b273da220b5e9b0e153de3a11f41bd109ee07c95b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Additives</topic><topic>Amino acids</topic><topic>Analytical Chemistry</topic><topic>ATOMIC AND MOLECULAR PHYSICS</topic><topic>ATOMS</topic><topic>Bioinformatics</topic><topic>Biotechnology</topic><topic>Bromination</topic><topic>CAPTURE</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Ethers</topic><topic>HELIUM</topic><topic>High temperature</topic><topic>High voltages</topic><topic>Hormones</topic><topic>HYDROGEN</topic><topic>ION SOURCES</topic><topic>IONIZATION</topic><topic>Ions</topic><topic>Mass spectrometry</topic><topic>MASS SPECTROSCOPY</topic><topic>NITROGEN</topic><topic>Organic Chemistry</topic><topic>OXIDATION</topic><topic>OXYGEN</topic><topic>Pesticides</topic><topic>PHENYL ETHER</topic><topic>Polarity</topic><topic>Proteomics</topic><topic>REACTION KINETICS</topic><topic>Reaction mechanisms</topic><topic>Reactive oxygen species</topic><topic>Real time</topic><topic>Research Article</topic><topic>Scientific imaging</topic><topic>Spectroscopy</topic><topic>SULFUR</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Su, Rui</creatorcontrib><creatorcontrib>Yu, Wenjing</creatorcontrib><creatorcontrib>Sun, Kaiju</creatorcontrib><creatorcontrib>Yang, Jie</creatorcontrib><creatorcontrib>Chen, Changbao</creatorcontrib><creatorcontrib>Lian, Wenhui</creatorcontrib><creatorcontrib>Liu, Shuying</creatorcontrib><creatorcontrib>Yang, Hongmei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Journal of the American Society for Mass Spectrometry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Su, Rui</au><au>Yu, Wenjing</au><au>Sun, Kaiju</au><au>Yang, Jie</au><au>Chen, Changbao</au><au>Lian, Wenhui</au><au>Liu, Shuying</au><au>Yang, Hongmei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Ion Source of Nitrogen Direct Analysis in Real-Time Mass Spectrometry as a Highly Efficient Reactor: Generation of Reactive Oxygen Species</atitle><jtitle>Journal of the American Society for Mass Spectrometry</jtitle><stitle>J. Am. Soc. Mass Spectrom</stitle><addtitle>J Am Soc Mass Spectrom</addtitle><date>2019-04-01</date><risdate>2019</risdate><volume>30</volume><issue>4</issue><spage>581</spage><epage>587</epage><pages>581-587</pages><issn>1044-0305</issn><eissn>1879-1123</eissn><abstract>An innovative strategy for sustainably active oxygen capture using nitrogen (N
2
) instead of helium (He) as direct analysis in real-time (DART) gas is demonstrated in this work. DART MS was carried out to analyze different polarity compounds including organophosphorus pesticides, amino acids, hormones, and poly brominated diphenyl ethers by using He and N
2
as DART gas, respectively. The unexpectedly characteristic ionization reactions, including replacement reaction where the sulfur atom of P=S group, were replaced by oxygen atom, oxidation ([M + nO + H]
+
or [M + nO-H]
−
(
n
= 1, 2, 3, 4, 5)), and hydrogen loss (loss of two hydrogens) rapidly occurred in situ in the presence of N
2
under ambient conditions without any additives. The reaction mechanisms were proposed and further confirmed by high-resolution tandem mass spectrometry. Our study under high temperature and high voltage provides a powerful tool for generating unique ionic species that may be difficult to form by other means, which also creates favorable conditions for the future study of the mechanism of DART MS.
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| fulltext | fulltext |
| identifier | ISSN: 1044-0305 |
| ispartof | Journal of the American Society for Mass Spectrometry, 2019-04, Vol.30 (4), p.581-587 |
| issn | 1044-0305 1879-1123 |
| language | eng |
| recordid | cdi_osti_scitechconnect_22923040 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Additives Amino acids Analytical Chemistry ATOMIC AND MOLECULAR PHYSICS ATOMS Bioinformatics Biotechnology Bromination CAPTURE Chemistry Chemistry and Materials Science Ethers HELIUM High temperature High voltages Hormones HYDROGEN ION SOURCES IONIZATION Ions Mass spectrometry MASS SPECTROSCOPY NITROGEN Organic Chemistry OXIDATION OXYGEN Pesticides PHENYL ETHER Polarity Proteomics REACTION KINETICS Reaction mechanisms Reactive oxygen species Real time Research Article Scientific imaging Spectroscopy SULFUR |
| title | The Ion Source of Nitrogen Direct Analysis in Real-Time Mass Spectrometry as a Highly Efficient Reactor: Generation of Reactive Oxygen Species |
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