Vascular endothelial growth factor mediates ceramide 1-phosphate-stimulated macrophage proliferation

The bioactive sphingolipid ceramide 1-phosphate (C1P) regulates cell division in a variety of cell types including macrophages. However, the mechanisms involved in this action are not completely understood. In the present work we show that C1P stimulates the release of vascular endothelial growth fa...

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Veröffentlicht in:	Experimental cell research 2017-12, Vol.361 (2), p.277-283
Hauptverfasser:	Ouro, Alberto, Arana, Lide, Riazy, Maziar, Zhang, Peng, Gomez-Larrauri, Ana, Steinbrecher, Urs, Duronio, Vincent, Gomez-Muñoz, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals ANTIBODIES Antibodies, Neutralizing - pharmacology CELL DIVISION Cell Division - drug effects Cell Line Cell Membrane - drug effects Cell Membrane - metabolism CELL PROLIFERATION Cell Proliferation - drug effects Ceramide 1-phosphate Ceramides - antagonists & inhibitors Ceramides - pharmacology GENES GROWTH FACTORS INHIBITION MACROPHAGES Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Mice Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - metabolism PHOSPHATES Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism PHOSPHOTRANSFERASES PLANT GROWTH Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Pyrimidines - pharmacology RECEPTORS RNA, Small Interfering - genetics RNA, Small Interfering - metabolism SECRETION Sphingolipids STIMULATION Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factor Receptor-2 - metabolism VEGF
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