Inhibition of tissue factor signaling in breast tumour xenografts induces widespread changes in the microRNA expression profile

Tissue factor (TF) is a transmembrane receptor for coagulation factor VII/VIIa and is frequently overexpressed by cancer cells. The TF/VIIa complex acts as the main initiator of the clotting cascade in blood and a trigger of intracellular signaling that changes gene expression and the cellular pheno...

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Veröffentlicht in:	Biochemical and biophysical research communications 2017-12, Vol.494 (3-4), p.700-705
Hauptverfasser:	D'Asti, Esterina, Anderson, G. Mark, Rak, Janusz
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ABSORPTION SPECTROSCOPY ACUTE EXPOSURE ANIMAL TISSUES Animals BIOLOGICAL MARKERS BIOLOGICAL PATHWAYS BLOOD BLOOD COAGULATION FACTORS Breast Neoplasms - metabolism Cancer Cell Line, Tumor Cell Proliferation Cell Survival COAGULANTS Gene Expression Regulation, Neoplastic Gene Regulatory Networks Humans IN VIVO INHIBITION INJECTION LYMPHOKINES MAMMARY GLANDS MICE microRNA MicroRNAs - metabolism MONOCLONAL ANTIBODIES NEOPLASMS PHENOTYPE RECEPTORS Signal Transduction Signalling Therapy Thromboplastin - antagonists & inhibitors Thromboplastin - metabolism Tissue factor Tumor Microenvironment X-RAY SPECTROSCOPY
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