The first minutes in the life of a peroxisomal matrix protein

In the field of intracellular protein sorting, peroxisomes are most famous by their capacity to import oligomeric proteins. The data supporting this remarkable property are abundant and, understandably, have inspired a variety of hypothetical models on how newly synthesized (cytosolic) proteins reac...

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Veröffentlicht in:Biochimica et biophysica acta 2016-05, Vol.1863 (5), p.814-820
Hauptverfasser: Dias, Ana F., Francisco, Tânia, Rodrigues, Tony A., Grou, Cláudia P., Azevedo, Jorge E.
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container_issue 5
container_start_page 814
container_title Biochimica et biophysica acta
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creator Dias, Ana F.
Francisco, Tânia
Rodrigues, Tony A.
Grou, Cláudia P.
Azevedo, Jorge E.
description In the field of intracellular protein sorting, peroxisomes are most famous by their capacity to import oligomeric proteins. The data supporting this remarkable property are abundant and, understandably, have inspired a variety of hypothetical models on how newly synthesized (cytosolic) proteins reach the peroxisome matrix. However, there is also accumulating evidence suggesting that many peroxisomal oligomeric proteins actually arrive at the peroxisome still as monomers. In support of this idea, recent data suggest that PEX5, the shuttling receptor for peroxisomal matrix proteins, is also a chaperone/holdase, binding newly synthesized peroxisomal proteins in the cytosol and blocking their oligomerization. Here we review the data behind these two different perspectives and discuss their mechanistic implications on this protein sorting pathway. This article is part of a Special Issue entitled: Peroxisomes edited by Ralf Erdmann. •The vast majority of peroxisomal matrix proteins are homo-oligomers.•How these proteins are sorted to the organelle has been a matter of debate.•We argue that this sorting pathway is best explained by a monomer-based import mechanism.
doi_str_mv 10.1016/j.bbamcr.2015.09.025
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subjects Animals
Eukaryotic Cells - chemistry
Eukaryotic Cells - metabolism
Gene Expression Regulation
Humans
Peroxisomal Targeting Signal 2 Receptor
Peroxisome
Peroxisome-Targeting Signal 1 Receptor
Peroxisomes - chemistry
Peroxisomes - metabolism
PEX5
PEX7
Plants - chemistry
Plants - metabolism
Protein Isoforms - chemistry
Protein Isoforms - genetics
Protein Isoforms - metabolism
Protein Multimerization
Protein Structure, Secondary
Protein Structure, Tertiary
Protein translocation
Protein Transport
PTS1
PTS2
Receptors, Cytoplasmic and Nuclear - chemistry
Receptors, Cytoplasmic and Nuclear - genetics
Receptors, Cytoplasmic and Nuclear - metabolism
Saccharomyces cerevisiae - chemistry
Saccharomyces cerevisiae - metabolism
Signal Transduction
Time Factors
title The first minutes in the life of a peroxisomal matrix protein
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