Recent Advances in Copper Intercalators as Anticancer Agents
Copper is a part of various enzymes and helps them to function properly. It can be effectively used to produce promising anticancer drugs and presently, many studies are being pursued worldwide on the development of copper-based complexes as potential anticancer drugs. Herein, we briefly discuss the...
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| Veröffentlicht in: | Journal of fluorescence 2018-09, Vol.28 (5), p.1195-1205 |
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| creator | Shobha Devi, C. Thulasiram, B. Aerva, Rajeshwar Rao Nagababu, Penumaka |
| description | Copper is a part of various enzymes and helps them to function properly. It can be effectively used to produce promising anticancer drugs and presently, many studies are being pursued worldwide on the development of copper-based complexes as potential anticancer drugs. Herein, we briefly discuss the importance of reactive oxygen species in biological applications and copper(II) complexes as anticancer drugs. The anti-angiogenic properties of mono-nuclear copper(II) complexes have been demonstrated by in vivo chick embryo angiogenesis analysis. The plausible mechanism behind anticancer activity of these complexes is by the formation of excessive intracellular Reactive Oxygen Species (ROS). ROS is a composite term used for oxygen derivative non-radicals and free radicals of highly reactive components, that enhances the killing response of immune cells to microbial invasion. Previous reports have shown that ROS plays an important role as a messenger in cell cycling and normal cell signal transduction.
Graphical Abstract
The generation of singlet oxygen and healing the tumor cells with singlet oxygen in presence of UV-light. |
| doi_str_mv | 10.1007/s10895-018-2283-7 |
| format | Article |
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Graphical Abstract
The generation of singlet oxygen and healing the tumor cells with singlet oxygen in presence of UV-light.</description><identifier>ISSN: 1053-0509</identifier><identifier>ISSN: 1573-4994</identifier><identifier>EISSN: 1573-4994</identifier><identifier>DOI: 10.1007/s10895-018-2283-7</identifier><identifier>PMID: 30171479</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>60 APPLIED LIFE SCIENCES ; Analytical Chemistry ; ANGIOGENESIS ; Angiogenesis Inducing Agents - chemistry ; Angiogenesis Inducing Agents - pharmacology ; Animals ; Anticancer properties ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; ANTINEOPLASTIC DRUGS ; Biochemistry ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biomedicine ; Biophysics ; Biotechnology ; Cancer ; COMPLEXES ; Coordination compounds ; COPPER ; Copper - chemistry ; Copper compounds ; DNA ; Drugs ; EMBRYOS ; ENZYMES ; Free radicals ; Humans ; Immune system ; IN VIVO ; Microorganisms ; NEOPLASMS ; Organometallic Compounds - chemistry ; Organometallic Compounds - pharmacology ; Original Article ; OXYGEN ; RADICALS ; Reactive Oxygen Species - metabolism ; Signal transduction ; SIGNALS</subject><ispartof>Journal of fluorescence, 2018-09, Vol.28 (5), p.1195-1205</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Copyright Springer Science & Business Media 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-9f82850bc32768272067176e263bb4c017f59fd45b43a5ad6a8dd59b78f2e9a13</citedby><cites>FETCH-LOGICAL-c400t-9f82850bc32768272067176e263bb4c017f59fd45b43a5ad6a8dd59b78f2e9a13</cites><orcidid>0000-0002-4489-2288</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10895-018-2283-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10895-018-2283-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30171479$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22795598$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Shobha Devi, C.</creatorcontrib><creatorcontrib>Thulasiram, B.</creatorcontrib><creatorcontrib>Aerva, Rajeshwar Rao</creatorcontrib><creatorcontrib>Nagababu, Penumaka</creatorcontrib><title>Recent Advances in Copper Intercalators as Anticancer Agents</title><title>Journal of fluorescence</title><addtitle>J Fluoresc</addtitle><addtitle>J Fluoresc</addtitle><description>Copper is a part of various enzymes and helps them to function properly. It can be effectively used to produce promising anticancer drugs and presently, many studies are being pursued worldwide on the development of copper-based complexes as potential anticancer drugs. Herein, we briefly discuss the importance of reactive oxygen species in biological applications and copper(II) complexes as anticancer drugs. The anti-angiogenic properties of mono-nuclear copper(II) complexes have been demonstrated by in vivo chick embryo angiogenesis analysis. The plausible mechanism behind anticancer activity of these complexes is by the formation of excessive intracellular Reactive Oxygen Species (ROS). ROS is a composite term used for oxygen derivative non-radicals and free radicals of highly reactive components, that enhances the killing response of immune cells to microbial invasion. Previous reports have shown that ROS plays an important role as a messenger in cell cycling and normal cell signal transduction.
Graphical Abstract
The generation of singlet oxygen and healing the tumor cells with singlet oxygen in presence of UV-light.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>Analytical Chemistry</subject><subject>ANGIOGENESIS</subject><subject>Angiogenesis Inducing Agents - chemistry</subject><subject>Angiogenesis Inducing Agents - pharmacology</subject><subject>Animals</subject><subject>Anticancer properties</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>ANTINEOPLASTIC DRUGS</subject><subject>Biochemistry</subject><subject>Biological and Medical Physics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biophysics</subject><subject>Biotechnology</subject><subject>Cancer</subject><subject>COMPLEXES</subject><subject>Coordination compounds</subject><subject>COPPER</subject><subject>Copper - chemistry</subject><subject>Copper compounds</subject><subject>DNA</subject><subject>Drugs</subject><subject>EMBRYOS</subject><subject>ENZYMES</subject><subject>Free radicals</subject><subject>Humans</subject><subject>Immune system</subject><subject>IN VIVO</subject><subject>Microorganisms</subject><subject>NEOPLASMS</subject><subject>Organometallic Compounds - chemistry</subject><subject>Organometallic Compounds - pharmacology</subject><subject>Original Article</subject><subject>OXYGEN</subject><subject>RADICALS</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Signal transduction</subject><subject>SIGNALS</subject><issn>1053-0509</issn><issn>1573-4994</issn><issn>1573-4994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1KAzEUhYMoVqsP4EYG3LgZvckkkwTclOJPoSCIrkMmk6lT2kxNMoJvb8rUduUqgXzn5N5zELrCcIcB-H3AICTLAYucEFHk_AidYcaLnEpJj9MdWJEDAzlC5yEsAUAKKk7RqADMMeXyDD28WWNdzCb1t3bGhqx12bTbbKzPZi5ab_RKx86HTIds4mJrtpTPJoskChfopNGrYC935xh9PD2-T1_y-evzbDqZ54YCxFw2gggGlSkILwXhBEqOeWlJWVQVNWmWhsmmpqyihWa6LrWoayYrLhpipcbFGN0Mvl2IrQqmjdZ8ms45a6IihEvGpEjU7UBtfPfV2xDVug3Grlba2a4PiqTtOU-ZwMFwjy673ru0gyJ4G22JCU0UHijjuxC8bdTGt2vtfxQGtaXUUIBKBahtAYonzfXOua_Wtt4r_hJPABmAkJ7cwvrD1_-7_gJmSI0w</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Shobha Devi, C.</creator><creator>Thulasiram, B.</creator><creator>Aerva, Rajeshwar Rao</creator><creator>Nagababu, Penumaka</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope><orcidid>https://orcid.org/0000-0002-4489-2288</orcidid></search><sort><creationdate>20180901</creationdate><title>Recent Advances in Copper Intercalators as Anticancer Agents</title><author>Shobha Devi, C. ; 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Graphical Abstract
The generation of singlet oxygen and healing the tumor cells with singlet oxygen in presence of UV-light.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30171479</pmid><doi>10.1007/s10895-018-2283-7</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-4489-2288</orcidid></addata></record> |
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| subjects | 60 APPLIED LIFE SCIENCES Analytical Chemistry ANGIOGENESIS Angiogenesis Inducing Agents - chemistry Angiogenesis Inducing Agents - pharmacology Animals Anticancer properties Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology ANTINEOPLASTIC DRUGS Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biomedicine Biophysics Biotechnology Cancer COMPLEXES Coordination compounds COPPER Copper - chemistry Copper compounds DNA Drugs EMBRYOS ENZYMES Free radicals Humans Immune system IN VIVO Microorganisms NEOPLASMS Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Original Article OXYGEN RADICALS Reactive Oxygen Species - metabolism Signal transduction SIGNALS |
| title | Recent Advances in Copper Intercalators as Anticancer Agents |
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