The p105 NF-ĸB precursor is a pseudo substrate of the ubiquitin ligase FBXO7, and its binding to the ligase stabilizes it and results in stimulated cell proliferation

The NF-κB transcription factor is involved in inflammation and cell proliferation, survival, and transformation. It is a heterodimer made of p50 or p52 and a member of the Rel family of proteins. p50 and p52 are derived from limited ubiquitin- and proteasome-mediated proteolytic processing of the la...

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Veröffentlicht in:	Biochemical and biophysical research communications 2021-06, Vol.558 (C), p.224-230
Hauptverfasser:	Udasin, Ronald G., Gottfried, Yossi, Fabre, Bertrand, Bercovich, Beatrice, Ziv, Tamar, Ciechanover, Aaron
Format:	Artikel
Sprache:	eng
Schlagworte:	FBXO7 NF-κB p105 Protein degradation Ubiquitin-proteasome system
Online-Zugang:	Volltext
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