Improved Miniaturized Linear Ion Trap Mass Spectrometer Using Lithographically Patterned Plates and Tapered Ejection Slit
We present a new two-plate linear ion trap mass spectrometer that overcomes both performance-based and miniaturization-related issues with prior designs. Borosilicate glass substrates are patterned with aluminum electrodes on one side and wire-bonded to printed circuit boards. Ions are trapped in th...
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| Veröffentlicht in: | Journal of the American Society for Mass Spectrometry 2018-02, Vol.29 (2), p.213-222 |
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| container_title | Journal of the American Society for Mass Spectrometry |
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| creator | Tian, Yuan Decker, Trevor K. McClellan, Joshua S. Bennett, Linsey Li, Ailin De la Cruz, Abraham Andrews, Derek Lammert, Stephen A. Hawkins, Aaron R. Austin, Daniel E. |
| description | We present a new two-plate linear ion trap mass spectrometer that overcomes both performance-based and miniaturization-related issues with prior designs. Borosilicate glass substrates are patterned with aluminum electrodes on one side and wire-bonded to printed circuit boards. Ions are trapped in the space between two such plates. Tapered ejection slits in each glass plate eliminate issues with charge build-up within the ejection slit and with blocking of ions that are ejected at off-nominal angles. The tapered slit allows miniaturization of the trap features (electrode size, slit width) needed for further reduction of trap size while allowing the use of substrates that are still thick enough to provide ruggedness during handling, assembly, and in-field applications. Plate spacing was optimized during operation using a motorized translation stage. A scan rate of 2300 Th/s with a sample mixture of toluene and deuterated toluene (D8) and xylenes (a mixture of
o-, m-, p-
) showed narrowest peak widths of 0.33 Th (FWHM).
Graphical Abstract
ᅟ |
| doi_str_mv | 10.1007/s13361-017-1759-z |
| format | Article |
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o-, m-, p-
) showed narrowest peak widths of 0.33 Th (FWHM).
Graphical Abstract
ᅟ</description><identifier>ISSN: 1044-0305</identifier><identifier>EISSN: 1879-1123</identifier><identifier>DOI: 10.1007/s13361-017-1759-z</identifier><identifier>PMID: 28836122</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>ALUMINIUM ; Aluminum ; Analytical Chemistry ; Bioinformatics ; Biotechnology ; BOROSILICATE GLASS ; Chemical bonds ; Chemistry ; Chemistry and Materials Science ; Circuit boards ; Deuteration ; Ejection ; ELECTRODES ; Focus: 32nd Asilomar Conference ; Glass plates ; Glass substrates ; INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY ; IONS ; MASS SPECTROMETERS ; Mass spectrometry ; MINIATURIZATION ; Novel Instrumentation in MS and Ion Mobility: Research Article ; Organic Chemistry ; Proteomics ; REDUCTION ; RESOLUTION ; Ruggedness ; Slits ; Toluene ; TRAPS</subject><ispartof>Journal of the American Society for Mass Spectrometry, 2018-02, Vol.29 (2), p.213-222</ispartof><rights>American Society for Mass Spectrometry 2017</rights><rights>Journal of The American Society for Mass Spectrometry is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-46d99064d6c8a11626a2c65bf4d4a8b81a2dcca4a729834eb62099f680a7fb043</citedby><cites>FETCH-LOGICAL-c400t-46d99064d6c8a11626a2c65bf4d4a8b81a2dcca4a729834eb62099f680a7fb043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13361-017-1759-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13361-017-1759-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28836122$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22776792$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Tian, Yuan</creatorcontrib><creatorcontrib>Decker, Trevor K.</creatorcontrib><creatorcontrib>McClellan, Joshua S.</creatorcontrib><creatorcontrib>Bennett, Linsey</creatorcontrib><creatorcontrib>Li, Ailin</creatorcontrib><creatorcontrib>De la Cruz, Abraham</creatorcontrib><creatorcontrib>Andrews, Derek</creatorcontrib><creatorcontrib>Lammert, Stephen A.</creatorcontrib><creatorcontrib>Hawkins, Aaron R.</creatorcontrib><creatorcontrib>Austin, Daniel E.</creatorcontrib><title>Improved Miniaturized Linear Ion Trap Mass Spectrometer Using Lithographically Patterned Plates and Tapered Ejection Slit</title><title>Journal of the American Society for Mass Spectrometry</title><addtitle>J. Am. Soc. Mass Spectrom</addtitle><addtitle>J Am Soc Mass Spectrom</addtitle><description>We present a new two-plate linear ion trap mass spectrometer that overcomes both performance-based and miniaturization-related issues with prior designs. Borosilicate glass substrates are patterned with aluminum electrodes on one side and wire-bonded to printed circuit boards. Ions are trapped in the space between two such plates. Tapered ejection slits in each glass plate eliminate issues with charge build-up within the ejection slit and with blocking of ions that are ejected at off-nominal angles. The tapered slit allows miniaturization of the trap features (electrode size, slit width) needed for further reduction of trap size while allowing the use of substrates that are still thick enough to provide ruggedness during handling, assembly, and in-field applications. Plate spacing was optimized during operation using a motorized translation stage. A scan rate of 2300 Th/s with a sample mixture of toluene and deuterated toluene (D8) and xylenes (a mixture of
o-, m-, p-
) showed narrowest peak widths of 0.33 Th (FWHM).
Graphical Abstract
ᅟ</description><subject>ALUMINIUM</subject><subject>Aluminum</subject><subject>Analytical Chemistry</subject><subject>Bioinformatics</subject><subject>Biotechnology</subject><subject>BOROSILICATE GLASS</subject><subject>Chemical bonds</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Circuit boards</subject><subject>Deuteration</subject><subject>Ejection</subject><subject>ELECTRODES</subject><subject>Focus: 32nd Asilomar Conference</subject><subject>Glass plates</subject><subject>Glass substrates</subject><subject>INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY</subject><subject>IONS</subject><subject>MASS SPECTROMETERS</subject><subject>Mass spectrometry</subject><subject>MINIATURIZATION</subject><subject>Novel Instrumentation in MS and Ion Mobility: Research Article</subject><subject>Organic Chemistry</subject><subject>Proteomics</subject><subject>REDUCTION</subject><subject>RESOLUTION</subject><subject>Ruggedness</subject><subject>Slits</subject><subject>Toluene</subject><subject>TRAPS</subject><issn>1044-0305</issn><issn>1879-1123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kc1u1DAURi0EomXgAdigSGzYBGzHseMlqgqMNBWVOl1bN44z41HiBNtTaebpuVVKu2Llv3OPr_0R8pHRr4xS9S2xqpKspEyVTNW6PL8il6xRumSMV69xToUoaUXrC_IupQNFkGr1llzwpsFCzi_JaT3OcXpwXXHjg4d8jP6Mi40PDmKxnkKxjTAXN5BScTc7m-M0uuxicZ982CGX99MOib23MAyn4hYyngZU3A6QXSogdMUWZhdx6_qAAo_Ou8Hn9-RND0NyH57GFbn_cb29-lVufv9cX33flFZQmkshO62pFJ20DTAmuQRuZd32ohPQtA0D3lkLAhTXTSVcKznVupcNBdW3VFQr8nnxTil7k6zPzu7tFAL2YjhXSirNkfqyUPgbf44uZTP6ZN0wQHDTMRmmK86kqJv6RfiMHqZjDPgGwynlldYCO1kRtlA2TilF15s5-hHiyTBqHtMzS3oGQzGP6Zkz1nx6Mh_b0XXPFf_iQoAvQMKjsHPx5er_W_8Cdm6lXQ</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Tian, Yuan</creator><creator>Decker, Trevor K.</creator><creator>McClellan, Joshua S.</creator><creator>Bennett, Linsey</creator><creator>Li, Ailin</creator><creator>De la Cruz, Abraham</creator><creator>Andrews, Derek</creator><creator>Lammert, Stephen A.</creator><creator>Hawkins, Aaron R.</creator><creator>Austin, Daniel E.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>20180201</creationdate><title>Improved Miniaturized Linear Ion Trap Mass Spectrometer Using Lithographically Patterned Plates and Tapered Ejection Slit</title><author>Tian, Yuan ; 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Am. Soc. Mass Spectrom</stitle><addtitle>J Am Soc Mass Spectrom</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>29</volume><issue>2</issue><spage>213</spage><epage>222</epage><pages>213-222</pages><issn>1044-0305</issn><eissn>1879-1123</eissn><abstract>We present a new two-plate linear ion trap mass spectrometer that overcomes both performance-based and miniaturization-related issues with prior designs. Borosilicate glass substrates are patterned with aluminum electrodes on one side and wire-bonded to printed circuit boards. Ions are trapped in the space between two such plates. Tapered ejection slits in each glass plate eliminate issues with charge build-up within the ejection slit and with blocking of ions that are ejected at off-nominal angles. The tapered slit allows miniaturization of the trap features (electrode size, slit width) needed for further reduction of trap size while allowing the use of substrates that are still thick enough to provide ruggedness during handling, assembly, and in-field applications. Plate spacing was optimized during operation using a motorized translation stage. A scan rate of 2300 Th/s with a sample mixture of toluene and deuterated toluene (D8) and xylenes (a mixture of
o-, m-, p-
) showed narrowest peak widths of 0.33 Th (FWHM).
Graphical Abstract
ᅟ</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28836122</pmid><doi>10.1007/s13361-017-1759-z</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of the American Society for Mass Spectrometry, 2018-02, Vol.29 (2), p.213-222 |
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| subjects | ALUMINIUM Aluminum Analytical Chemistry Bioinformatics Biotechnology BOROSILICATE GLASS Chemical bonds Chemistry Chemistry and Materials Science Circuit boards Deuteration Ejection ELECTRODES Focus: 32nd Asilomar Conference Glass plates Glass substrates INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY IONS MASS SPECTROMETERS Mass spectrometry MINIATURIZATION Novel Instrumentation in MS and Ion Mobility: Research Article Organic Chemistry Proteomics REDUCTION RESOLUTION Ruggedness Slits Toluene TRAPS |
| title | Improved Miniaturized Linear Ion Trap Mass Spectrometer Using Lithographically Patterned Plates and Tapered Ejection Slit |
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