A Parallel Approach to Post Source Decay MALDI-TOF Analysis
We present a novel enhancement to matrix-assisted laser desorption ionization (MALDI) post-source decay (PSD) analysis whereby fragment ions from multiple precursor ions are acquired into the same spectrum without employing a timed ion gate to preselect each parent ion. Fragment ions are matched to...
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| Veröffentlicht in: | Journal of the American Society for Mass Spectrometry 2006-01, Vol.17 (1), p.60-66 |
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| container_title | Journal of the American Society for Mass Spectrometry |
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| creator | Kenny, D.J. Brown, J.M. Palmer, M.E. Snel, M.F. Bateman, R.H. |
| description | We present a novel enhancement to matrix-assisted laser desorption ionization (MALDI) post-source decay (PSD) analysis whereby fragment ions from multiple precursor ions are acquired into the same spectrum without employing a timed ion gate to preselect each parent ion. Fragment ions are matched to their corresponding precursor ions by comparing spectra acquired at slightly different reflectron electric fields. By measuring the difference in time-of-flight (TOF) between the two spectra for each fragment, it is possible to calculate the mass of the fragment ion and its parent. This new “parallel PSD” technique reduces analysis time and consumes less sample than conventional PSD, which requires an ion gate for serial preselection of precursor ions. |
| doi_str_mv | 10.1016/j.jasms.2005.09.006 |
| format | Article |
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Fragment ions are matched to their corresponding precursor ions by comparing spectra acquired at slightly different reflectron electric fields. By measuring the difference in time-of-flight (TOF) between the two spectra for each fragment, it is possible to calculate the mass of the fragment ion and its parent. This new “parallel PSD” technique reduces analysis time and consumes less sample than conventional PSD, which requires an ion gate for serial preselection of precursor ions.</description><identifier>ISSN: 1044-0305</identifier><identifier>EISSN: 1879-1123</identifier><identifier>DOI: 10.1016/j.jasms.2005.09.006</identifier><identifier>PMID: 16352437</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Algorithms ; Amino Acid Sequence ; Aminoacids, peptides. Hormones. Neuropeptides ; Analytical, structural and metabolic biochemistry ; Angiotensin II - chemistry ; Biological and medical sciences ; COMPARATIVE EVALUATIONS ; Coumaric Acids - chemistry ; Data Interpretation, Statistical ; Decay ; DESORPTION ; ELECTRIC FIELDS ; Fragmentation ; Fundamental and applied biological sciences. Psychology ; Indicators and Reagents ; INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY ; IONIZATION ; IONS ; Least-Squares Analysis ; Mass spectrometry ; Molecular Sequence Data ; Peptides - chemistry ; Protein Hydrolysates - chemistry ; Proteins ; Saccharomyces cerevisiae - chemistry ; SPECTRA ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods ; TIME-OF-FLIGHT METHOD</subject><ispartof>Journal of the American Society for Mass Spectrometry, 2006-01, Vol.17 (1), p.60-66</ispartof><rights>2005 American Society for Mass Spectrometry</rights><rights>2006 INIST-CNRS</rights><rights>Journal of The American Society for Mass Spectrometry is a copyright of Springer, (2005). 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Fragment ions are matched to their corresponding precursor ions by comparing spectra acquired at slightly different reflectron electric fields. By measuring the difference in time-of-flight (TOF) between the two spectra for each fragment, it is possible to calculate the mass of the fragment ion and its parent. This new “parallel PSD” technique reduces analysis time and consumes less sample than conventional PSD, which requires an ion gate for serial preselection of precursor ions.</description><subject>Algorithms</subject><subject>Amino Acid Sequence</subject><subject>Aminoacids, peptides. Hormones. 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| subjects | Algorithms Amino Acid Sequence Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Angiotensin II - chemistry Biological and medical sciences COMPARATIVE EVALUATIONS Coumaric Acids - chemistry Data Interpretation, Statistical Decay DESORPTION ELECTRIC FIELDS Fragmentation Fundamental and applied biological sciences. Psychology Indicators and Reagents INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY IONIZATION IONS Least-Squares Analysis Mass spectrometry Molecular Sequence Data Peptides - chemistry Protein Hydrolysates - chemistry Proteins Saccharomyces cerevisiae - chemistry SPECTRA Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods TIME-OF-FLIGHT METHOD |
| title | A Parallel Approach to Post Source Decay MALDI-TOF Analysis |
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