Radiation Dose and Risk Estimates of CT-Guided Percutaneous Liver Ablations and Factors Associated with Dose Reduction

Purpose To determine the radiation dose associated with CT-guided percutaneous liver ablations and identify potential risk factors that result in higher radiation doses. Materials and Methods Between June 2011 and June 2015, 245 consecutive patients underwent 304 CT-guided liver ablation treatments....

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Veröffentlicht in:Cardiovascular and interventional radiology 2018-12, Vol.41 (12), p.1935-1942
Hauptverfasser: McCarthy, Colin J., Kilcoyne, Aoife, Li, Xinhua, Cahalane, Alexis M., Liu, Bob, Arellano, Ronald S., Uppot, Raul N., Gee, Michael S.
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container_end_page 1942
container_issue 12
container_start_page 1935
container_title Cardiovascular and interventional radiology
container_volume 41
creator McCarthy, Colin J.
Kilcoyne, Aoife
Li, Xinhua
Cahalane, Alexis M.
Liu, Bob
Arellano, Ronald S.
Uppot, Raul N.
Gee, Michael S.
description Purpose To determine the radiation dose associated with CT-guided percutaneous liver ablations and identify potential risk factors that result in higher radiation doses. Materials and Methods Between June 2011 and June 2015, 245 consecutive patients underwent 304 CT-guided liver ablation treatments. Patient demographics, tumor characteristics and procedural parameters were identified and analyzed. The peak skin dose and effective dose were assessed for each procedure. Excess relative risk related to radiation effects was calculated. A logistic regression model was prepared by means of stepwise logistic regression to identify variables predictive of increased radiation exposure. Results Tumor ablations were performed with microwave ( n  = 220), radiofrequency ( n  = 74) or irreversible electroporation (IRE) ( n  = 10). The mean peak skin dose for ablations was 239.2 ± 136.4 mGy, and the mean effective dose was 36.6 ± 22.3 mSv. Of the patient and procedural parameters that were analyzed, increasing weight, use of intravenous contrast and/or hydrodissection during the procedure, together with treatment of multiple lesions in the same sitting were all associated with higher radiation exposure. The mean increase in the absolute risk of fatal malignancy from a single procedure was 0.18% (range 0.02–0.9%). No deterministic skin changes were identified in the patient cohort. Conclusion The overall risk of stochastic and deterministic effects from radiation associated with CT-guided ablations is low compared with other inherent procedural complications. This study identifies several factors that are associated with higher radiation dose in percutaneous liver ablation procedures.
doi_str_mv 10.1007/s00270-018-2066-1
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Materials and Methods Between June 2011 and June 2015, 245 consecutive patients underwent 304 CT-guided liver ablation treatments. Patient demographics, tumor characteristics and procedural parameters were identified and analyzed. The peak skin dose and effective dose were assessed for each procedure. Excess relative risk related to radiation effects was calculated. A logistic regression model was prepared by means of stepwise logistic regression to identify variables predictive of increased radiation exposure. Results Tumor ablations were performed with microwave ( n  = 220), radiofrequency ( n  = 74) or irreversible electroporation (IRE) ( n  = 10). The mean peak skin dose for ablations was 239.2 ± 136.4 mGy, and the mean effective dose was 36.6 ± 22.3 mSv. Of the patient and procedural parameters that were analyzed, increasing weight, use of intravenous contrast and/or hydrodissection during the procedure, together with treatment of multiple lesions in the same sitting were all associated with higher radiation exposure. The mean increase in the absolute risk of fatal malignancy from a single procedure was 0.18% (range 0.02–0.9%). No deterministic skin changes were identified in the patient cohort. Conclusion The overall risk of stochastic and deterministic effects from radiation associated with CT-guided ablations is low compared with other inherent procedural complications. This study identifies several factors that are associated with higher radiation dose in percutaneous liver ablation procedures.</description><identifier>ISSN: 0174-1551</identifier><identifier>EISSN: 1432-086X</identifier><identifier>DOI: 10.1007/s00270-018-2066-1</identifier><identifier>PMID: 30132100</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>ABLATION ; Ablation Techniques - methods ; Aged ; Cardiology ; Clinical Investigation ; Clinical Protocols ; Complications ; CT-GUIDED RADIOTHERAPY ; Demographics ; Demography ; EFFECTIVE RADIATION DOSES ; Electroporation ; Exposure ; Female ; Health risk assessment ; Humans ; Imaging ; Intravenous administration ; Lesions ; LIVER ; Liver cancer ; Liver Neoplasms - surgery ; Male ; Malignancy ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; NEOPLASMS ; Nuclear Medicine ; PATIENTS ; Radiation Dosage ; Radiation effects ; Radiation Exposure - statistics &amp; numerical data ; RADIATION HAZARDS ; Radiation Protection ; Radio frequency ; Radiography, Interventional - methods ; Radiology ; RADIOLOGY AND NUCLEAR MEDICINE ; Retrospective Studies ; Risk analysis ; Risk Assessment - methods ; Risk factors ; Skin ; Tomography, X-Ray Computed - methods ; Tumors ; Ultrasound ; Weight</subject><ispartof>Cardiovascular and interventional radiology, 2018-12, Vol.41 (12), p.1935-1942</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2018</rights><rights>CardioVascular and Interventional Radiology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-138a813d3ec3fd07cfab2a6385bfc31a64e483cc034d00d76754c2aaf44ffb343</citedby><cites>FETCH-LOGICAL-c400t-138a813d3ec3fd07cfab2a6385bfc31a64e483cc034d00d76754c2aaf44ffb343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00270-018-2066-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00270-018-2066-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30132100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22749691$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>McCarthy, Colin J.</creatorcontrib><creatorcontrib>Kilcoyne, Aoife</creatorcontrib><creatorcontrib>Li, Xinhua</creatorcontrib><creatorcontrib>Cahalane, Alexis M.</creatorcontrib><creatorcontrib>Liu, Bob</creatorcontrib><creatorcontrib>Arellano, Ronald S.</creatorcontrib><creatorcontrib>Uppot, Raul N.</creatorcontrib><creatorcontrib>Gee, Michael S.</creatorcontrib><title>Radiation Dose and Risk Estimates of CT-Guided Percutaneous Liver Ablations and Factors Associated with Dose Reduction</title><title>Cardiovascular and interventional radiology</title><addtitle>Cardiovasc Intervent Radiol</addtitle><addtitle>Cardiovasc Intervent Radiol</addtitle><description>Purpose To determine the radiation dose associated with CT-guided percutaneous liver ablations and identify potential risk factors that result in higher radiation doses. Materials and Methods Between June 2011 and June 2015, 245 consecutive patients underwent 304 CT-guided liver ablation treatments. Patient demographics, tumor characteristics and procedural parameters were identified and analyzed. The peak skin dose and effective dose were assessed for each procedure. Excess relative risk related to radiation effects was calculated. A logistic regression model was prepared by means of stepwise logistic regression to identify variables predictive of increased radiation exposure. Results Tumor ablations were performed with microwave ( n  = 220), radiofrequency ( n  = 74) or irreversible electroporation (IRE) ( n  = 10). The mean peak skin dose for ablations was 239.2 ± 136.4 mGy, and the mean effective dose was 36.6 ± 22.3 mSv. Of the patient and procedural parameters that were analyzed, increasing weight, use of intravenous contrast and/or hydrodissection during the procedure, together with treatment of multiple lesions in the same sitting were all associated with higher radiation exposure. The mean increase in the absolute risk of fatal malignancy from a single procedure was 0.18% (range 0.02–0.9%). No deterministic skin changes were identified in the patient cohort. Conclusion The overall risk of stochastic and deterministic effects from radiation associated with CT-guided ablations is low compared with other inherent procedural complications. This study identifies several factors that are associated with higher radiation dose in percutaneous liver ablation procedures.</description><subject>ABLATION</subject><subject>Ablation Techniques - methods</subject><subject>Aged</subject><subject>Cardiology</subject><subject>Clinical Investigation</subject><subject>Clinical Protocols</subject><subject>Complications</subject><subject>CT-GUIDED RADIOTHERAPY</subject><subject>Demographics</subject><subject>Demography</subject><subject>EFFECTIVE RADIATION DOSES</subject><subject>Electroporation</subject><subject>Exposure</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Imaging</subject><subject>Intravenous administration</subject><subject>Lesions</subject><subject>LIVER</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - surgery</subject><subject>Male</subject><subject>Malignancy</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Middle Aged</subject><subject>NEOPLASMS</subject><subject>Nuclear Medicine</subject><subject>PATIENTS</subject><subject>Radiation Dosage</subject><subject>Radiation effects</subject><subject>Radiation Exposure - statistics &amp; 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Public Health</topic><topic>Middle Aged</topic><topic>NEOPLASMS</topic><topic>Nuclear Medicine</topic><topic>PATIENTS</topic><topic>Radiation Dosage</topic><topic>Radiation effects</topic><topic>Radiation Exposure - statistics &amp; numerical data</topic><topic>RADIATION HAZARDS</topic><topic>Radiation Protection</topic><topic>Radio frequency</topic><topic>Radiography, Interventional - methods</topic><topic>Radiology</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Retrospective Studies</topic><topic>Risk analysis</topic><topic>Risk Assessment - methods</topic><topic>Risk factors</topic><topic>Skin</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Tumors</topic><topic>Ultrasound</topic><topic>Weight</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McCarthy, Colin J.</creatorcontrib><creatorcontrib>Kilcoyne, Aoife</creatorcontrib><creatorcontrib>Li, Xinhua</creatorcontrib><creatorcontrib>Cahalane, Alexis M.</creatorcontrib><creatorcontrib>Liu, Bob</creatorcontrib><creatorcontrib>Arellano, Ronald S.</creatorcontrib><creatorcontrib>Uppot, Raul N.</creatorcontrib><creatorcontrib>Gee, Michael S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing &amp; 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Materials and Methods Between June 2011 and June 2015, 245 consecutive patients underwent 304 CT-guided liver ablation treatments. Patient demographics, tumor characteristics and procedural parameters were identified and analyzed. The peak skin dose and effective dose were assessed for each procedure. Excess relative risk related to radiation effects was calculated. A logistic regression model was prepared by means of stepwise logistic regression to identify variables predictive of increased radiation exposure. Results Tumor ablations were performed with microwave ( n  = 220), radiofrequency ( n  = 74) or irreversible electroporation (IRE) ( n  = 10). The mean peak skin dose for ablations was 239.2 ± 136.4 mGy, and the mean effective dose was 36.6 ± 22.3 mSv. Of the patient and procedural parameters that were analyzed, increasing weight, use of intravenous contrast and/or hydrodissection during the procedure, together with treatment of multiple lesions in the same sitting were all associated with higher radiation exposure. The mean increase in the absolute risk of fatal malignancy from a single procedure was 0.18% (range 0.02–0.9%). No deterministic skin changes were identified in the patient cohort. Conclusion The overall risk of stochastic and deterministic effects from radiation associated with CT-guided ablations is low compared with other inherent procedural complications. This study identifies several factors that are associated with higher radiation dose in percutaneous liver ablation procedures.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30132100</pmid><doi>10.1007/s00270-018-2066-1</doi><tpages>8</tpages></addata></record>
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subjects ABLATION
Ablation Techniques - methods
Aged
Cardiology
Clinical Investigation
Clinical Protocols
Complications
CT-GUIDED RADIOTHERAPY
Demographics
Demography
EFFECTIVE RADIATION DOSES
Electroporation
Exposure
Female
Health risk assessment
Humans
Imaging
Intravenous administration
Lesions
LIVER
Liver cancer
Liver Neoplasms - surgery
Male
Malignancy
Medicine
Medicine & Public Health
Middle Aged
NEOPLASMS
Nuclear Medicine
PATIENTS
Radiation Dosage
Radiation effects
Radiation Exposure - statistics & numerical data
RADIATION HAZARDS
Radiation Protection
Radio frequency
Radiography, Interventional - methods
Radiology
RADIOLOGY AND NUCLEAR MEDICINE
Retrospective Studies
Risk analysis
Risk Assessment - methods
Risk factors
Skin
Tomography, X-Ray Computed - methods
Tumors
Ultrasound
Weight
title Radiation Dose and Risk Estimates of CT-Guided Percutaneous Liver Ablations and Factors Associated with Dose Reduction
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