PIM kinases 1, 2 and 3 in intracellular LIF signaling, proliferation and apoptosis in trophoblastic cells

Proviral insertion in murine (PIM) lymphoma proteins are mainly regulated by the Janus Kinase/Signal Transducer Activator of Transcription (JAK/STAT) signaling pathway, which can be activated by members of the Interleukin-6 (IL-6) family, including Leukemia Inhibitory Factor (LIF). Aim of the study...

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Veröffentlicht in:	Experimental cell research 2017-10, Vol.359 (1), p.275-283
Hauptverfasser:	Mary Photini, Stella, Chaiwangyen, Wittaya, Weber, Maja, Al-Kawlani, Boodor, Favaro, Rodolfo R., Jeschke, Udo, Schleussner, Ekkehard, Morales-Prieto, Diana M., Markert, Udo R.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES APOPTOSIS Apoptosis - drug effects Cell Line CELL PROLIFERATION Cell Proliferation - drug effects Cell Survival - drug effects Flow Cytometry Humans Imidazoles - pharmacology Immunoblotting Intracellular signaling Intracellular Space - metabolism Leukemia Inhibitory Factor - metabolism LYMPHOKINES PHOSPHOTRANSFERASES PIM kinases Placenta Protein Kinase Inhibitors - pharmacology Protein Transport - drug effects Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-pim-1 - metabolism Pyridazines - pharmacology Reproduction Signal Transduction - drug effects SIGNALS Trophoblast Trophoblasts - cytology Trophoblasts - drug effects Trophoblasts - enzymology
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