SGLT2-inhibitor and DPP-4 inhibitor improve brain function via attenuating mitochondrial dysfunction, insulin resistance, inflammation, and apoptosis in HFD-induced obese rats

Dipeptidyl peptidase-4 inhibitor (vildagliptin) has been shown to exert beneficial effects on insulin sensitivity and neuroprotection in obese-insulin resistance. Recent studies demonstrated the neuroprotection of the sodium-glucose co-transporter 2 inhibitor (dapagliflozin) in diabetes. However, th...

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Veröffentlicht in:	Toxicology and applied pharmacology 2017-10, Vol.333, p.43-50
Hauptverfasser:	Sa-nguanmoo, Piangkwan, Tanajak, Pongpan, Kerdphoo, Sasiwan, Jaiwongkam, Thidarat, Pratchayasakul, Wasana, Chattipakorn, Nipon, Chattipakorn, Siriporn C.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Adamantane - analogs & derivatives Adamantane - pharmacology Adamantane - therapeutic use Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use APOPTOSIS Apoptosis - drug effects Benzhydryl Compounds - pharmacology Benzhydryl Compounds - therapeutic use BRAIN Brain - drug effects Brain - metabolism Brain - physiology Cognition Disorders - drug therapy Cognition Disorders - metabolism Cognition Disorders - physiopathology Cognitive function Dapagliflozin Diet, High-Fat Dipeptidyl-Peptidase IV Inhibitors - pharmacology Dipeptidyl-Peptidase IV Inhibitors - therapeutic use DRUGS GLUCOSE Glucosides - pharmacology Glucosides - therapeutic use INSULIN Insulin - physiology Insulin Resistance Long-Term Potentiation - drug effects Male Malondialdehyde - blood Malondialdehyde - metabolism Maze Learning - drug effects Membrane Potential, Mitochondrial - drug effects Memory - drug effects METABOLIC DISEASES MITOCHONDRIA Mitochondria - drug effects Mitochondria - metabolism Mitochondria - physiology Mitochondrial function Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Nitriles - pharmacology Nitriles - therapeutic use Obese-insulin resistance Obesity - drug therapy Obesity - metabolism Obesity - physiopathology Oxidative Stress - drug effects Pyrrolidines - pharmacology Pyrrolidines - therapeutic use RATS Rats, Wistar Reactive Oxygen Species - metabolism SENSITIVITY Sodium-Glucose Transporter 2 Sodium-Glucose Transporter 2 Inhibitors Synaptic plasticity Vildagliptin
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