Numb positively regulates autophagic flux via regulating lysosomal function

Autophagy is a lysosome-dependent catabolic process involving in the degradation and recycling of unnecessary or damaged proteins and organelles. Emerging evidence indicates that autophagy dysfunction is closely related to various human diseases including cancer, aging, myopathies and neurodegenerat...

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Veröffentlicht in:	Biochemical and biophysical research communications 2017-09, Vol.491 (3), p.780-786
Hauptverfasser:	Sun, Haiyan, Liu, Yi, Zhang, Lei, Shao, Ximing, Liu, Ke, Ding, Zhihao, Liu, Xianming, Jiang, Changan, Li, Huashun, Li, Hongchang
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES AGING Autophagy CATHEPSINS CELL CONSTITUENTS ENZYME ACTIVITY Gene Expression Regulation, Enzymologic GLUCOSIDASE GLUCURONIDASE Humans Hydrogen-Ion Concentration LIGHT BULBS Lysosomal Membrane Proteins - metabolism Lysosome LYSOSOMES Lysosomes - chemistry Lysosomes - metabolism MCF-7 Cells MEMBRANE PROTEINS Membrane Proteins - chemistry Membrane Proteins - metabolism NEOPLASMS Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - metabolism Numb PH VALUE rab GTP-Binding Proteins - metabolism Rab7 activity rab7 GTP-Binding Proteins TRANSMISSION ELECTRON MICROSCOPY Up-Regulation - physiology
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