Taxifolin enhances osteogenic differentiation of human bone marrow mesenchymal stem cells partially via NF-κB pathway

Taxifolin, a flavonoid compound, has been reported to stimulate osteogenic differentiation in osteoblasts. The present study investigated whether taxifolin affects the osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) and the molecular mechanisms involved. The prolifera...

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Veröffentlicht in:	Biochemical and biophysical research communications 2017-08, Vol.490 (1), p.36-43
Hauptverfasser:	Wang, Yun-Jia, Zhang, Hong-Qi, Han, Hai-Long, Zou, Yong-Yi, Gao, Qi-Le, Yang, Guan-Teng
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ALIZARIN ALKALINE PHOSPHATASE BONE MARROW Cell Differentiation - drug effects Cells, Cultured CONNECTIVE TISSUE CELLS DMSO Dose-Response Relationship, Drug ESTROGENS Flavonoid FLAVONOIDS Humans LUCIFERASE Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism MITOGENS Molecular Structure MSC NF-kappa B - metabolism NF-κB Osteogenesis Osteogenesis - drug effects PHOSPHOTRANSFERASES POLYMERASE CHAIN REACTION Protein Transport - drug effects Quercetin - analogs & derivatives Quercetin - pharmacology RECEPTORS Signal Transduction - drug effects SKELETON STEM CELLS Structure-Activity Relationship Taxifolin TOXICITY TRANSCRIPTION TRANSCRIPTION FACTORS TRANSLOCATION
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