Sigma-2 ligands and PARP inhibitors synergistically trigger cell death in breast cancer cells

The sigma-2 receptor is overexpressed in proliferating cells compared to quiescent cells and has been used as a target for imaging solid tumors by positron emission tomography. Recent work has suggested that the sigma-2 receptor may also be an effective therapeutic target for cancer therapy. Poly (A...

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Veröffentlicht in:	Biochemical and biophysical research communications 2017-05, Vol.486 (3)
Hauptverfasser:	McDonald, Elizabeth S., Mankoff, Julia, Makvandi, Mehran, Chu, Wenhua, Chu, Yunxiang, Mach, Robert H., Zeng, Chenbo
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES APOPTOSIS BIOMEDICAL RADIOGRAPHY CELL CYCLE CELL PROLIFERATION DNA DAMAGES INHIBITION LIGANDS MAMMARY GLANDS NEOPLASMS POSITRON COMPUTED TOMOGRAPHY RECEPTORS TUMOR CELLS
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