TEAD4-YAP interaction regulates tumoral growth by controlling cell-cycle arrest at the G1 phase

TEA domain transcription factor 4 (TEAD4), which has critical functions in the process of embryonic development, is expressed in various cancers. However, the important role of TEAD4 in human oral squamous cell carcinomas (OSCCs) remain unclear. Here we investigated the TEAD4 expression level and th...

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Veröffentlicht in:	Biochemical and biophysical research communications 2017-04, Vol.486 (2), p.385-390
Hauptverfasser:	Takeuchi, Shin, Kasamatsu, Atsushi, Yamatoji, Masanobu, Nakashima, Dai, Endo-Sakamoto, Yosuke, Koide, Nao, Takahara, Toshikazu, Shimizu, Toshihiro, Iyoda, Manabu, Ogawara, Katsunori, Shiiba, Masashi, Tanzawa, Hideki, Uzawa, Katsuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Aged BIOLOGICAL MARKERS Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery CELL CYCLE Cell Line, Tumor Cell Nucleus - genetics Cell Nucleus - metabolism CELL PROLIFERATION CHAIN REACTIONS Cyclin D1 - genetics Cyclin D1 - metabolism Cyclin E - genetics Cyclin E - metabolism Cyclin-Dependent Kinase 2 - genetics Cyclin-Dependent Kinase 2 - metabolism Cyclin-Dependent Kinase 4 - genetics Cyclin-Dependent Kinase 4 - metabolism Cyclin-Dependent Kinase 6 - genetics Cyclin-Dependent Kinase 6 - metabolism Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Cyclin-Dependent Kinase Inhibitor p27 - genetics Cyclin-Dependent Kinase Inhibitor p27 - metabolism DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female G1 Phase Cell Cycle Checkpoints Gene Expression Regulation, Neoplastic Human oral squamous cell carcinoma Humans INTERACTIONS Male Middle Aged Mouth Neoplasms - genetics Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Mouth Neoplasms - surgery Muscle Proteins - antagonists & inhibitors Muscle Proteins - genetics Muscle Proteins - metabolism Phosphoproteins - genetics Phosphoproteins - metabolism PLANT GROWTH RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Signal Transduction TEA domain transcription factor 4 TRANSCRIPTION FACTORS Transcription Factors - antagonists & inhibitors Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Yes-associated protein (YAP)
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