Rifampin suppresses osteoclastogenesis and titanium particle-induced osteolysis via modulating RANKL signaling pathways

Wear particles liberated from the surface of prostheses are considered to be main reason for osteoclast bone resorption and that extensive osteoclastogenesis leads to peri-implant osteolysis and subsequent prosthetic loosening. The aim of this study was to assess the effect of rifampin on osteoclast...

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Veröffentlicht in:	Biochemical and biophysical research communications 2017-02, Vol.484 (1), p.64-70
Hauptverfasser:	Zhu, Liang, Kang, Hui, Guo, Chang-an, Fan, Wen-shuai, Wang, Yi-ming, Deng, Lian-fu, Yan, Zuo-qin
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ACID PHOSPHATASE Animals BONE MARROW Cell Differentiation Dose-Response Relationship, Drug Gene Expression - drug effects INHIBITION Mice NF-kappa B - metabolism NF-κB Osteogenesis - drug effects Osteolysis Osteolysis - chemically induced P38 p38 Mitogen-Activated Protein Kinases - metabolism PARTICLES PHOSPHORUS 38 RANK Ligand - metabolism Rifampin Rifampin - pharmacology Signal Transduction - drug effects SIGNALS SKELETON TITANIUM Titanium - toxicity TRAPS Wear particles X-Ray Microtomography
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