Metabolic biomarkers for non-alcoholic fatty liver disease induced by high-fat diet: In vivo magnetic resonance spectroscopy of hyperpolarized [1-13C] pyruvate

Hyperpolarized 13C magnetic resonance spectroscopy (MRS) to assess hepatic metabolism in non-alcoholic fatty liver disease (NAFLD) has not been reported. This study searched for cellular metabolism-based biomarkers for NAFLD induced by a high-fat diet (HFD) in rats. Also, correlations of the biomark...

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Veröffentlicht in:	Biochemical and biophysical research communications 2017-01, Vol.482 (1), p.112-119
Hauptverfasser:	Moon, Chung-Man, Oh, Chang-Hyun, Ahn, Kyu-Youn, Yang, Jun-Seok, Kim, Jae-Young, Shin, Sang-Soo, Lim, Hyo-Soon, Heo, Sook-Hee, Seon, Hyun-Ju, Kim, Jin-Woong, Jeong, Gwang-Woo
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Alanine - metabolism ALANINES Animals BIOLOGICAL MARKERS Biomarkers - metabolism CARBON 13 Carbon-13 Magnetic Resonance Spectroscopy - methods DIET Diet, High-Fat Dietary Fats - metabolism DISEASES Dynamic nuclear polarization (DNP) High-fat diet Hyperpolarized 13C LACTATE DEHYDROGENASE Lactic Acid - metabolism LIVER MAGNETIC RESONANCE Male METABOLISM Non-alcoholic fatty liver disease (NAFLD) Non-alcoholic Fatty Liver Disease - diagnosis Non-alcoholic Fatty Liver Disease - metabolism Pyruvic Acid - pharmacokinetics RATS Rats, Sprague-Dawley Reproducibility of Results Sensitivity and Specificity SPECTROSCOPY
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