Potential transfer of neurotoxic amino acid β-N-methylamino-alanine (BMAA) from mother to infant during breast-feeding: Predictions from human cell lines

β-N-methylamino-alanine (BMAA) is a non-protein amino acid produced by cyanobacteria, diatoms and dinoflagellates. BMAA has potential to biomagnify in a terrestrial food chain, and to bioaccumulate in fish and shellfish. We have reported that administration of [14C]l-BMAA to lactating mice and rats...

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Veröffentlicht in:	Toxicology and applied pharmacology 2017-04, Vol.320, p.40-50
Hauptverfasser:	Andersson, Marie, Ersson, Lisa, Brandt, Ingvar, Bergström, Ulrika
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ABSORPTION ALANINES Amino acid transporters Amino Acids, Diamino - metabolism Amino Acids, Diamino - toxicity Animals Biological Transport - drug effects Biological Transport - physiology BMAA BRAIN Breast Feeding - adverse effects Breast milk Caco-2 Cells CARBON 14 Cell Differentiation - drug effects Cell Differentiation - physiology Cell Line Cellular transport CYANOBACTERIA DIATOMS DINOFLAGELLATE Dose-Response Relationship, Drug EPITHELIUM Excitatory Amino Acid Agonists - metabolism Excitatory Amino Acid Agonists - toxicity Female FOOD CHAINS Forecasting GLIOMAS Humans IN VITRO IN VIVO Infant, Newborn INFANTS INTESTINES LACTATES Lactation - drug effects Lactation - metabolism MAMMARY GLANDS Maternal Exposure - adverse effects MCF-7 Cells MICE MILK Mothers NERVE CELLS Neurodegeneration PERMEABILITY PROTEINS RATS UPTAKE
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