Sibutramine provokes apoptosis of aortic endothelial cells through altered production of reactive oxygen and nitrogen species

Overdose administration of sibutramine, a serotonin-noradrenalin reuptake inhibitor, is considered to elicit severe side effects including hypertension, whose pathogenic mechanism remains unclear. Here, we found that 48-h incubation with >10μM sibutramine provokes apoptosis of human aortic endoth...

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Veröffentlicht in:	Toxicology and applied pharmacology 2017-01, Vol.314, p.1-11
Hauptverfasser:	Morikawa, Yoshifumi, Shibata, Akinobu, Okumura, Naoko, Ikari, Akira, Sasajima, Yasuhide, Suenami, Koichi, Sato, Kiyohito, Takekoshi, Yuji, El-Kabbani, Ossama, Matsunaga, Toshiyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ABUNDANCE Antidepressive Agents - pharmacology Aorta - cytology Aorta - drug effects Aorta - metabolism APOPTOSIS Apoptosis - drug effects Cells, Cultured Cyclobutanes - pharmacology CYTOCHROMES ENDOPLASMIC RETICULUM Endoplasmic Reticulum Stress Endothelial cell Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism HEAT-SHOCK PROTEINS Humans HYPERTENSION INHIBITION LIVER LIVER CELLS METABOLISM METABOLITES NITRIC OXIDE NITROGEN Oxidative Stress OXYGEN PATHOGENESIS PROTEOLYSIS Reactive Nitrogen Species - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism SEROTONIN Sibutramine SIDE EFFECTS TOXICITY VASOCONSTRICTION
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