UDCA and CDCA alleviate 17α-ethinylestradiol-induced cholestasis through PKA-AMPK pathways in rats

Estrogen-induced cholestasis, known as intrahepatic cholestasis of pregnancy (ICP), is an estrogen-related liver disease that is widely recognized as female or pregnancy-specific. Our previous findings showed that the synthetic estrogen, 17α-ethinylestradiol (EE), induced cholestatic injury through...

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Veröffentlicht in:	Toxicology and applied pharmacology 2016-11, Vol.311, p.12-25
Hauptverfasser:	Li, Xiaojiaoyang, Yuan, Zihang, Liu, Runping, Hassan, Hozeifa M., Yang, Hang, Sun, Rong, Zhang, Luyong, Jiang, Zhenzhou
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ABUNDANCE Adenylate Kinase - metabolism AMP AMPK Animals BILE BILE ACIDS Carrier Proteins - metabolism CDCA Cells, Cultured Chenodeoxycholic Acid - pharmacology Cholestasis - chemically induced Cholestasis - prevention & control CONCENTRATION RATIO Cyclic AMP-Dependent Protein Kinases - metabolism Dose-Response Relationship, Drug ENVIRONMENTAL SCIENCES Enzyme Activation ESTROGENS Ethinyl Estradiol - toxicity Female ICP IN VIVO INHIBITION INJURIES LIVER LIVER CELLS Male Membrane Glycoproteins - metabolism PHOSPHORYLATION PHOSPHOTRANSFERASES PKA PREGNANCY Protein Kinase Inhibitors - pharmacology RATS Rats, Sprague-Dawley RECEPTORS UDCA Ursodeoxycholic Acid - pharmacology
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