Subcellular mechanisms involved in apoptosis induced by aminoglycoside antibiotics: Insights on p53, proteasome and endoplasmic reticulum

Gentamicin, an aminoglycoside used to treat severe bacterial infections, may cause acute renal failure. In the renal cell line LLC-PK1, gentamicin accumulates in lysosomes, induces alterations of their permeability, and triggers the mitochondrial pathway of apoptosis via activation of caspase-9 and...

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Veröffentlicht in:	Toxicology and applied pharmacology 2016-10, Vol.309, p.24-36
Hauptverfasser:	Denamur, Sophie, Boland, Lidvine, Beyaert, Maxime, Verstraeten, Sandrine L., Fillet, Marianne, Tulkens, Paul M., Bontemps, Françoise, Mingeot-Leclercq, Marie-Paule
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Aminoglycosides Animals Anti-Bacterial Agents - pharmacology ANTIBIOTICS APOPTOSIS Apoptosis - drug effects Apoptosis - physiology Apoptosis/drug effects/physiology BUILDUP CHYMOTRYPSIN ENDOPLASMIC RETICULUM Endoplasmic Reticulum - metabolism FAILURES Gentamicin Gentamicins - adverse effects Gentamicins - pharmacology Gentamicins/adverse effects/pharmacology Human health sciences INHIBITION KIDNEYS LLC-PK1 Cells LYSOSOMES MITOCHONDRIA Molecular Chaperones - metabolism MONOCLINIC LATTICES p53 PERMEABILITY Pharmacie, pharmacologie & toxicologie Pharmacy, pharmacology & toxicology Proteasome Proteasome Endopeptidase Complex - metabolism Proto-Oncogene Proteins p21(ras) - metabolism Reactive Oxygen Species - metabolism RNA, Small Interfering - genetics Sciences de la santé humaine Sphingomyelin Phosphodiesterase - metabolism Subcellular Fractions - metabolism Subcellular Fractions - physiology Subcellular Fractions/metabolism/physiology Swine TOXICITY TRYPSIN Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Protein p53/genetics/metabolism
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