Experimental determination of the PTW 60019 microDiamond dosimeter active area and volume
Purpose: Small field output correction factors have been studied by several research groups for the PTW 60019 microDiamond (MD) dosimeter, by comparing the response of such a device with both reference dosimeters and Monte Carlo simulations. A general good agreement is observed for field sizes down...
Gespeichert in:
Veröffentlicht in: | Medical physics (Lancaster) 2016-09, Vol.43 (9), p.5205-5212 |
---|---|
Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 5212 |
---|---|
container_issue | 9 |
container_start_page | 5205 |
container_title | Medical physics (Lancaster) |
container_volume | 43 |
creator | Marinelli, Marco Prestopino, G. Verona, C. Verona-Rinati, G. |
description | Purpose:
Small field output correction factors have been studied by several research groups for the PTW 60019 microDiamond (MD) dosimeter, by comparing the response of such a device with both reference dosimeters and Monte Carlo simulations. A general good agreement is observed for field sizes down to about 1 cm. However, evident inconsistencies can be noticed when comparing some experimental results and Monte Carlo simulations obtained for smaller irradiation fields. This issue was tentatively attributed by some authors to unintentional large variations of the MD active surface area. The aim of the present study is a nondestructive experimental determination of the MD active surface area and active volume.
Methods:
Ten MD dosimeters, one MD prototype, and three synthetic diamond samples were investigated in the present work. 2D maps of the MD response were recorded under scanned soft x-ray microbeam irradiation, leading to an experimental determination of the device active surface area. Profiles of the device responses were measured as well. In order to evaluate the MD active volume, the thickness of the diamond sensing layer was independently evaluated by capacitance measurements and alpha particle detection experiments. The MD sensitivity, measured at the PTW calibration laboratory, was also used to calculate the device active volume thickness.
Results:
An average active surface area diameter of (2.19 ± 0.02) mm was evaluated by 2D maps and response profiles of all the MDs. Average active volume thicknesses of (1.01 ± 0.13) μm and (0.97 ± 0.14) μm were derived by capacitance and sensitivity measurements, respectively. The obtained results are well in agreement with the nominal values reported in the manufacturer dosimeter specifications. A homogeneous response was observed over the whole device active area. Besides the one from the device active volume, no contributions from other components of the housing nor from encapsulation materials were observed in the 2D response maps.
Conclusions:
The obtained results demonstrate the high reproducibility of the MD fabrication process. The observed discrepancies among the output correction factors reported by several authors for MD response in very small fields are very unlikely to be ascribed to unintentional variations of the device active surface area and volume. It is the opinion of the authors that the role of the volume averaging as well as of other perturbation effects should be separately investigated in |
doi_str_mv | 10.1118/1.4961402 |
format | Article |
fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_22689290</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1816638198</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4212-24bb028a0bdd88acb9c537c4b12c9465e25f11d9a05520752c997a7544d25ab43</originalsourceid><addsrcrecordid>eNp90U9vFCEYBnDSaNq1eugXaEi8VJOpLwzMwLFp65-kxh5qjCfCwDspzcywHdjVfnupsxov9UQCPx7ggZAjBqeMMfWOnQrdMAF8j6y4aOtKcNDPyApAi4oLkAfkRUp3ANDUEvbJAW-lakHyFfl--XONcxhxynagHjPOY5hsDnGisaf5Fun1zTfaADBNx-DmeBHsGCdPfUxlW_HUuhy2SO2Mltqyso3DZsSX5Hlvh4SvduMh-fr-8ub8Y3X15cOn87OrygnOeLle1wFXFjrvlbKu007WrRMd406LRiKXPWNeW5CSQyvLrG5tK4XwXNpO1Ifk9ZIbUw4muZDR3bo4Teiy4bxRmmso6mRR6znebzBlM4bkcBjshHGTDFOsaWrFtCr0zULLY1OasTfrUpCdHwwD89i3YWbXd7HHu9hNN6L_K_8UXEC1gB9hwIenk8zn613g28U_PuT3N_z39CfxNs7_hK99X_8C0pShng</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1816638198</pqid></control><display><type>article</type><title>Experimental determination of the PTW 60019 microDiamond dosimeter active area and volume</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Marinelli, Marco ; Prestopino, G. ; Verona, C. ; Verona-Rinati, G.</creator><creatorcontrib>Marinelli, Marco ; Prestopino, G. ; Verona, C. ; Verona-Rinati, G.</creatorcontrib><description>Purpose:
Small field output correction factors have been studied by several research groups for the PTW 60019 microDiamond (MD) dosimeter, by comparing the response of such a device with both reference dosimeters and Monte Carlo simulations. A general good agreement is observed for field sizes down to about 1 cm. However, evident inconsistencies can be noticed when comparing some experimental results and Monte Carlo simulations obtained for smaller irradiation fields. This issue was tentatively attributed by some authors to unintentional large variations of the MD active surface area. The aim of the present study is a nondestructive experimental determination of the MD active surface area and active volume.
Methods:
Ten MD dosimeters, one MD prototype, and three synthetic diamond samples were investigated in the present work. 2D maps of the MD response were recorded under scanned soft x-ray microbeam irradiation, leading to an experimental determination of the device active surface area. Profiles of the device responses were measured as well. In order to evaluate the MD active volume, the thickness of the diamond sensing layer was independently evaluated by capacitance measurements and alpha particle detection experiments. The MD sensitivity, measured at the PTW calibration laboratory, was also used to calculate the device active volume thickness.
Results:
An average active surface area diameter of (2.19 ± 0.02) mm was evaluated by 2D maps and response profiles of all the MDs. Average active volume thicknesses of (1.01 ± 0.13) μm and (0.97 ± 0.14) μm were derived by capacitance and sensitivity measurements, respectively. The obtained results are well in agreement with the nominal values reported in the manufacturer dosimeter specifications. A homogeneous response was observed over the whole device active area. Besides the one from the device active volume, no contributions from other components of the housing nor from encapsulation materials were observed in the 2D response maps.
Conclusions:
The obtained results demonstrate the high reproducibility of the MD fabrication process. The observed discrepancies among the output correction factors reported by several authors for MD response in very small fields are very unlikely to be ascribed to unintentional variations of the device active surface area and volume. It is the opinion of the authors that the role of the volume averaging as well as of other perturbation effects should be separately investigated instead, both experimentally and by Monte Carlo simulations, in order to better clarify the behaviour of the MD response in very small fields.</description><identifier>ISSN: 0094-2405</identifier><identifier>EISSN: 2473-4209</identifier><identifier>DOI: 10.1118/1.4961402</identifier><identifier>PMID: 27587052</identifier><identifier>CODEN: MPHYA6</identifier><language>eng</language><publisher>United States: American Association of Physicists in Medicine</publisher><subject>60 APPLIED LIFE SCIENCES ; active surface area ; active volume ; Applications ; Applications of Monte Carlo methods ; Arrangements for measuring resistance, reactance, impedance, or electric characteristics derived therefrom ; Biological material, e.g. blood, urine; Haemocytometers ; Calibrating of instruments or apparatus ; calibration ; Capacitance ; capacitance measurement ; COMPUTERIZED SIMULATION ; diagnostic radiography ; Diamond ; DOSEMETERS ; Dose‐volume analysis ; dosimetry ; Dosimetry/exposure assessment ; Elemental semiconductors ; encapsulation ; IRRADIATION ; Measuring inductance or capacitance; Measuring quality factor, e.g. by using the resonance method; Measuring loss factor; Measuring dielectric constants ; microDiamond ; MONTE CARLO METHOD ; Monte Carlo methods ; Monte Carlo simulations ; Optical microscopes ; perturbation theory ; Photoelectric conversion ; RADIATION PROTECTION AND DOSIMETRY ; Radiography ; Radiometry - instrumentation ; Reproducibility of Results ; Scintigraphy ; small field dosimetry ; Soft X‐rays ; SURFACE AREA ; Surface Properties ; synthetic diamond ; Testing or calibrating of apparatus or arrangements provided for in groups G01D1/00 to G01D15/00 ; THICKNESS ; X‐ray imaging</subject><ispartof>Medical physics (Lancaster), 2016-09, Vol.43 (9), p.5205-5212</ispartof><rights>American Association of Physicists in Medicine</rights><rights>2016 American Association of Physicists in Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4212-24bb028a0bdd88acb9c537c4b12c9465e25f11d9a05520752c997a7544d25ab43</citedby><cites>FETCH-LOGICAL-c4212-24bb028a0bdd88acb9c537c4b12c9465e25f11d9a05520752c997a7544d25ab43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1118%2F1.4961402$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1118%2F1.4961402$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27587052$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22689290$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Marinelli, Marco</creatorcontrib><creatorcontrib>Prestopino, G.</creatorcontrib><creatorcontrib>Verona, C.</creatorcontrib><creatorcontrib>Verona-Rinati, G.</creatorcontrib><title>Experimental determination of the PTW 60019 microDiamond dosimeter active area and volume</title><title>Medical physics (Lancaster)</title><addtitle>Med Phys</addtitle><description>Purpose:
Small field output correction factors have been studied by several research groups for the PTW 60019 microDiamond (MD) dosimeter, by comparing the response of such a device with both reference dosimeters and Monte Carlo simulations. A general good agreement is observed for field sizes down to about 1 cm. However, evident inconsistencies can be noticed when comparing some experimental results and Monte Carlo simulations obtained for smaller irradiation fields. This issue was tentatively attributed by some authors to unintentional large variations of the MD active surface area. The aim of the present study is a nondestructive experimental determination of the MD active surface area and active volume.
Methods:
Ten MD dosimeters, one MD prototype, and three synthetic diamond samples were investigated in the present work. 2D maps of the MD response were recorded under scanned soft x-ray microbeam irradiation, leading to an experimental determination of the device active surface area. Profiles of the device responses were measured as well. In order to evaluate the MD active volume, the thickness of the diamond sensing layer was independently evaluated by capacitance measurements and alpha particle detection experiments. The MD sensitivity, measured at the PTW calibration laboratory, was also used to calculate the device active volume thickness.
Results:
An average active surface area diameter of (2.19 ± 0.02) mm was evaluated by 2D maps and response profiles of all the MDs. Average active volume thicknesses of (1.01 ± 0.13) μm and (0.97 ± 0.14) μm were derived by capacitance and sensitivity measurements, respectively. The obtained results are well in agreement with the nominal values reported in the manufacturer dosimeter specifications. A homogeneous response was observed over the whole device active area. Besides the one from the device active volume, no contributions from other components of the housing nor from encapsulation materials were observed in the 2D response maps.
Conclusions:
The obtained results demonstrate the high reproducibility of the MD fabrication process. The observed discrepancies among the output correction factors reported by several authors for MD response in very small fields are very unlikely to be ascribed to unintentional variations of the device active surface area and volume. It is the opinion of the authors that the role of the volume averaging as well as of other perturbation effects should be separately investigated instead, both experimentally and by Monte Carlo simulations, in order to better clarify the behaviour of the MD response in very small fields.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>active surface area</subject><subject>active volume</subject><subject>Applications</subject><subject>Applications of Monte Carlo methods</subject><subject>Arrangements for measuring resistance, reactance, impedance, or electric characteristics derived therefrom</subject><subject>Biological material, e.g. blood, urine; Haemocytometers</subject><subject>Calibrating of instruments or apparatus</subject><subject>calibration</subject><subject>Capacitance</subject><subject>capacitance measurement</subject><subject>COMPUTERIZED SIMULATION</subject><subject>diagnostic radiography</subject><subject>Diamond</subject><subject>DOSEMETERS</subject><subject>Dose‐volume analysis</subject><subject>dosimetry</subject><subject>Dosimetry/exposure assessment</subject><subject>Elemental semiconductors</subject><subject>encapsulation</subject><subject>IRRADIATION</subject><subject>Measuring inductance or capacitance; Measuring quality factor, e.g. by using the resonance method; Measuring loss factor; Measuring dielectric constants</subject><subject>microDiamond</subject><subject>MONTE CARLO METHOD</subject><subject>Monte Carlo methods</subject><subject>Monte Carlo simulations</subject><subject>Optical microscopes</subject><subject>perturbation theory</subject><subject>Photoelectric conversion</subject><subject>RADIATION PROTECTION AND DOSIMETRY</subject><subject>Radiography</subject><subject>Radiometry - instrumentation</subject><subject>Reproducibility of Results</subject><subject>Scintigraphy</subject><subject>small field dosimetry</subject><subject>Soft X‐rays</subject><subject>SURFACE AREA</subject><subject>Surface Properties</subject><subject>synthetic diamond</subject><subject>Testing or calibrating of apparatus or arrangements provided for in groups G01D1/00 to G01D15/00</subject><subject>THICKNESS</subject><subject>X‐ray imaging</subject><issn>0094-2405</issn><issn>2473-4209</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90U9vFCEYBnDSaNq1eugXaEi8VJOpLwzMwLFp65-kxh5qjCfCwDspzcywHdjVfnupsxov9UQCPx7ggZAjBqeMMfWOnQrdMAF8j6y4aOtKcNDPyApAi4oLkAfkRUp3ANDUEvbJAW-lakHyFfl--XONcxhxynagHjPOY5hsDnGisaf5Fun1zTfaADBNx-DmeBHsGCdPfUxlW_HUuhy2SO2Mltqyso3DZsSX5Hlvh4SvduMh-fr-8ub8Y3X15cOn87OrygnOeLle1wFXFjrvlbKu007WrRMd406LRiKXPWNeW5CSQyvLrG5tK4XwXNpO1Ifk9ZIbUw4muZDR3bo4Teiy4bxRmmso6mRR6znebzBlM4bkcBjshHGTDFOsaWrFtCr0zULLY1OasTfrUpCdHwwD89i3YWbXd7HHu9hNN6L_K_8UXEC1gB9hwIenk8zn613g28U_PuT3N_z39CfxNs7_hK99X_8C0pShng</recordid><startdate>201609</startdate><enddate>201609</enddate><creator>Marinelli, Marco</creator><creator>Prestopino, G.</creator><creator>Verona, C.</creator><creator>Verona-Rinati, G.</creator><general>American Association of Physicists in Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>201609</creationdate><title>Experimental determination of the PTW 60019 microDiamond dosimeter active area and volume</title><author>Marinelli, Marco ; Prestopino, G. ; Verona, C. ; Verona-Rinati, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4212-24bb028a0bdd88acb9c537c4b12c9465e25f11d9a05520752c997a7544d25ab43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>60 APPLIED LIFE SCIENCES</topic><topic>active surface area</topic><topic>active volume</topic><topic>Applications</topic><topic>Applications of Monte Carlo methods</topic><topic>Arrangements for measuring resistance, reactance, impedance, or electric characteristics derived therefrom</topic><topic>Biological material, e.g. blood, urine; Haemocytometers</topic><topic>Calibrating of instruments or apparatus</topic><topic>calibration</topic><topic>Capacitance</topic><topic>capacitance measurement</topic><topic>COMPUTERIZED SIMULATION</topic><topic>diagnostic radiography</topic><topic>Diamond</topic><topic>DOSEMETERS</topic><topic>Dose‐volume analysis</topic><topic>dosimetry</topic><topic>Dosimetry/exposure assessment</topic><topic>Elemental semiconductors</topic><topic>encapsulation</topic><topic>IRRADIATION</topic><topic>Measuring inductance or capacitance; Measuring quality factor, e.g. by using the resonance method; Measuring loss factor; Measuring dielectric constants</topic><topic>microDiamond</topic><topic>MONTE CARLO METHOD</topic><topic>Monte Carlo methods</topic><topic>Monte Carlo simulations</topic><topic>Optical microscopes</topic><topic>perturbation theory</topic><topic>Photoelectric conversion</topic><topic>RADIATION PROTECTION AND DOSIMETRY</topic><topic>Radiography</topic><topic>Radiometry - instrumentation</topic><topic>Reproducibility of Results</topic><topic>Scintigraphy</topic><topic>small field dosimetry</topic><topic>Soft X‐rays</topic><topic>SURFACE AREA</topic><topic>Surface Properties</topic><topic>synthetic diamond</topic><topic>Testing or calibrating of apparatus or arrangements provided for in groups G01D1/00 to G01D15/00</topic><topic>THICKNESS</topic><topic>X‐ray imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marinelli, Marco</creatorcontrib><creatorcontrib>Prestopino, G.</creatorcontrib><creatorcontrib>Verona, C.</creatorcontrib><creatorcontrib>Verona-Rinati, G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Medical physics (Lancaster)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marinelli, Marco</au><au>Prestopino, G.</au><au>Verona, C.</au><au>Verona-Rinati, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental determination of the PTW 60019 microDiamond dosimeter active area and volume</atitle><jtitle>Medical physics (Lancaster)</jtitle><addtitle>Med Phys</addtitle><date>2016-09</date><risdate>2016</risdate><volume>43</volume><issue>9</issue><spage>5205</spage><epage>5212</epage><pages>5205-5212</pages><issn>0094-2405</issn><eissn>2473-4209</eissn><coden>MPHYA6</coden><abstract>Purpose:
Small field output correction factors have been studied by several research groups for the PTW 60019 microDiamond (MD) dosimeter, by comparing the response of such a device with both reference dosimeters and Monte Carlo simulations. A general good agreement is observed for field sizes down to about 1 cm. However, evident inconsistencies can be noticed when comparing some experimental results and Monte Carlo simulations obtained for smaller irradiation fields. This issue was tentatively attributed by some authors to unintentional large variations of the MD active surface area. The aim of the present study is a nondestructive experimental determination of the MD active surface area and active volume.
Methods:
Ten MD dosimeters, one MD prototype, and three synthetic diamond samples were investigated in the present work. 2D maps of the MD response were recorded under scanned soft x-ray microbeam irradiation, leading to an experimental determination of the device active surface area. Profiles of the device responses were measured as well. In order to evaluate the MD active volume, the thickness of the diamond sensing layer was independently evaluated by capacitance measurements and alpha particle detection experiments. The MD sensitivity, measured at the PTW calibration laboratory, was also used to calculate the device active volume thickness.
Results:
An average active surface area diameter of (2.19 ± 0.02) mm was evaluated by 2D maps and response profiles of all the MDs. Average active volume thicknesses of (1.01 ± 0.13) μm and (0.97 ± 0.14) μm were derived by capacitance and sensitivity measurements, respectively. The obtained results are well in agreement with the nominal values reported in the manufacturer dosimeter specifications. A homogeneous response was observed over the whole device active area. Besides the one from the device active volume, no contributions from other components of the housing nor from encapsulation materials were observed in the 2D response maps.
Conclusions:
The obtained results demonstrate the high reproducibility of the MD fabrication process. The observed discrepancies among the output correction factors reported by several authors for MD response in very small fields are very unlikely to be ascribed to unintentional variations of the device active surface area and volume. It is the opinion of the authors that the role of the volume averaging as well as of other perturbation effects should be separately investigated instead, both experimentally and by Monte Carlo simulations, in order to better clarify the behaviour of the MD response in very small fields.</abstract><cop>United States</cop><pub>American Association of Physicists in Medicine</pub><pmid>27587052</pmid><doi>10.1118/1.4961402</doi><tpages>8</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0094-2405 |
ispartof | Medical physics (Lancaster), 2016-09, Vol.43 (9), p.5205-5212 |
issn | 0094-2405 2473-4209 |
language | eng |
recordid | cdi_osti_scitechconnect_22689290 |
source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Alma/SFX Local Collection |
subjects | 60 APPLIED LIFE SCIENCES active surface area active volume Applications Applications of Monte Carlo methods Arrangements for measuring resistance, reactance, impedance, or electric characteristics derived therefrom Biological material, e.g. blood, urine Haemocytometers Calibrating of instruments or apparatus calibration Capacitance capacitance measurement COMPUTERIZED SIMULATION diagnostic radiography Diamond DOSEMETERS Dose‐volume analysis dosimetry Dosimetry/exposure assessment Elemental semiconductors encapsulation IRRADIATION Measuring inductance or capacitance Measuring quality factor, e.g. by using the resonance method Measuring loss factor Measuring dielectric constants microDiamond MONTE CARLO METHOD Monte Carlo methods Monte Carlo simulations Optical microscopes perturbation theory Photoelectric conversion RADIATION PROTECTION AND DOSIMETRY Radiography Radiometry - instrumentation Reproducibility of Results Scintigraphy small field dosimetry Soft X‐rays SURFACE AREA Surface Properties synthetic diamond Testing or calibrating of apparatus or arrangements provided for in groups G01D1/00 to G01D15/00 THICKNESS X‐ray imaging |
title | Experimental determination of the PTW 60019 microDiamond dosimeter active area and volume |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T20%3A01%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_osti_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Experimental%20determination%20of%20the%20PTW%2060019%20microDiamond%20dosimeter%20active%20area%20and%20volume&rft.jtitle=Medical%20physics%20(Lancaster)&rft.au=Marinelli,%20Marco&rft.date=2016-09&rft.volume=43&rft.issue=9&rft.spage=5205&rft.epage=5212&rft.pages=5205-5212&rft.issn=0094-2405&rft.eissn=2473-4209&rft.coden=MPHYA6&rft_id=info:doi/10.1118/1.4961402&rft_dat=%3Cproquest_osti_%3E1816638198%3C/proquest_osti_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1816638198&rft_id=info:pmid/27587052&rfr_iscdi=true |