Valproic acid exposure decreases Cbp/p300 protein expression and histone acetyltransferase activity in P19 cells

The teratogenicity of the antiepileptic drug valproic acid (VPA) is well established and its inhibition of histone deacetylases (HDAC) is proposed as an initiating factor. Recently, VPA-mediated HDAC inhibition was demonstrated to involve transcriptional downregulation of histone acetyltransferases...

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Veröffentlicht in:	Toxicology and applied pharmacology 2016-09, Vol.306, p.69-78
Hauptverfasser:	Lamparter, Christina L., Winn, Louise M.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ACETYLATION Animals Anticonvulsants - pharmacology ANTIOXIDANTS APOPTOSIS Apoptosis - drug effects Benzoates - pharmacology Caspase 3 - metabolism CATALASE Cbp/p300 Cell Line CONGENITAL DISEASES CONGENITAL MALFORMATIONS Down-Regulation DRUGS Histone acetyltransferase Histone Acetyltransferases - metabolism HISTONES IN VITRO INHIBITION IODIDES MESSENGER-RNA Mice ONTOGENESIS OXYGEN P19 cells p300-CBP Transcription Factors - antagonists & inhibitors p300-CBP Transcription Factors - genetics p300-CBP Transcription Factors - metabolism POLYETHYLENE GLYCOLS POLYETHYLENES Pyrazoles - pharmacology Reactive Oxygen Species - metabolism RNA, Messenger - metabolism Teratogen TERATOGENESIS TERATOGENS Transcription Factor RelA - genetics Transcription Factor RelA - metabolism Valproic acid Valproic Acid - pharmacology
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