Nrf2 activation ameliorates cytotoxic effects of arsenic trioxide in acute promyelocytic leukemia cells through increased glutathione levels and arsenic efflux from cells

Carnosic acid (CA), a phenolic diterpene isolated from Rosmarinus officinalis, has been shown to activate nuclear transcription factor E2-related factor 2 (Nrf2), which plays a central role in cytoprotective responses to oxidative and electrophilic stress. Recently, the Nrf2-Kelch ECH associating pr...

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Veröffentlicht in:	Toxicology and applied pharmacology 2016-08, Vol.305, p.161-168
Hauptverfasser:	Nishimoto, Shoichi, Suzuki, Toshihiro, Koike, Shin, Yuan, Bo, Takagi, Norio, Ogasawara, Yuki
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Acute promyelocytic leukemia ANTINEOPLASTIC DRUGS ANTIOXIDANTS ARSENIC Arsenic - metabolism Arsenic trioxide Arsenicals ATTENUATION BIOSYNTHESIS Carnosic acid Cell Line, Tumor CYSTEINE Cytotoxins - toxicity DETOXIFICATION Diterpenes, Abietane - pharmacology ECR HEATING EDTA GLUTATHIONE Glutathione - metabolism HEME Humans ICP MASS SPECTROSCOPY IODIDES LEUKEMIA Leukemia, Promyelocytic, Acute - metabolism LIGASES MODULATION NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Nrf2 Oxides - toxicity OXYGENASES PEROXIDASES PHENOLS PHOSPHATES POLYMERASE CHAIN REACTION RETINOIC ACID RNA RNA, Small Interfering - genetics Rosmarinus officinalis SENSITIVITY SOLUTES TRANSCRIPTION TRANSCRIPTION FACTORS TRANSFERASES
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