Dual regulation of skin sensitizer-induced HMOX1 expression by Bach1 and Nrf2: Comparison to regulation of the AKR1C2-ARE element in the KeratinoSens cell line

Heme oxygenase (decycling) 1 (HMOX1) is the most consistently found genetic marker induced by skin sensitizers. HMOX1 is often referred to as typical gene regulated by nuclear factor erythroid 2-related factor 2 (Nrf2), however, it is also regulated by other DNA-binding factors, including BTB and CN...

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Veröffentlicht in:	Toxicology and applied pharmacology 2015-11, Vol.288 (3), p.281-288
Hauptverfasser:	Emter, Roger, Natsch, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Acrolein - analogs & derivatives Acrolein - toxicity Allergens - toxicity Antioxidant Response Elements - drug effects Bach1 Basic-Leucine Zipper Transcription Factors - genetics Basic-Leucine Zipper Transcription Factors - metabolism CALVES Cell Line Cloning, Molecular CONCENTRATION RATIO DIAGRAMS Dose-Response Relationship, Drug ECR HEATING Epigenetic Repression Fanconi Anemia Complementation Group Proteins - genetics Fanconi Anemia Complementation Group Proteins - metabolism Gene expression Gene Knockdown Techniques HEME Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism HMOX1 Humans Hydroxysteroid Dehydrogenases - genetics Hydroxysteroid Dehydrogenases - metabolism IN VITRO In vitro testing Keratinocytes - drug effects Keratinocytes - metabolism LUCIFERASE Luciferases - genetics Luciferases - metabolism LYMPH LYMPH NODES NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Nrf2 OXYGENASES POLYMERASES Promoter Regions, Genetic RNA, Small Interfering - genetics RNA, Small Interfering - metabolism SENSITIZERS SKIN Skin - metabolism Skin sensitization Up-Regulation VALIDATION
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