Technical solutions to reduce mediastinal irradiation in young patients undergoing treatment for lymphomas: Preliminary experience
Abstract This study aims at optimizing treatment planning in young patients affected by lymphoma (Stage II to III) by using an inclined board (IB) that allows reducing doses to the organs at risk. We evaluated 19 young patients affected by stage I to III lymphomas, referred to our Department for con...
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| Veröffentlicht in: | Medical dosimetry : official journal of the American Association of Medical Dosimetrists 2016, Vol.41 (4), p.281-284 |
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| creator | Benassi, Michaela, M.D Di Murro, Luana, M.D Tolu, Barbara, M.D Ponti, Elisabetta, M.D Falco, Maria Daniela, M.D Rossi, Carla, M.D Bagalà, Paolo, M.D di Cristino, Daniela, M.D Murgia, Alessandra, M.D Cicchetti, Sara, M.D Bruni, Claudia, M.D Morelli, Pasquale, M.D Lancia, Andrea, M.D Santoni, Riccardo, M.D |
| description | Abstract This study aims at optimizing treatment planning in young patients affected by lymphoma (Stage II to III) by using an inclined board (IB) that allows reducing doses to the organs at risk. We evaluated 19 young patients affected by stage I to III lymphomas, referred to our Department for consolidation radiotherapy (RT) treatment on the mediastinum. Patients underwent 2 planning computed tomography (CT) scans performed in different positions: flat standard position and inclined position. A direct comparison between the different treatment plans was carried out analyzing dosimetric parameters obtained from dose-volume histograms generated for each plan. Comparison was performed to evaluate the sparing obtained on breast and heart. Dosimetric evaluation was performed for the following organs at risk (OARs): mammary glands, lungs, and heart. A statistically significant advantage was reported for V5 , V20 , and V30 for the breast when using the inclined board. A similar result was obtained for V5 and V10 on the heart. No advantage was observed in lung doses. The use of a simple device, such as an inclined board, allows the optimization of treatment plan, especially in young female patients, by ensuring a significant reduction of the dose delivered to breast and heart. |
| doi_str_mv | 10.1016/j.meddos.2016.06.004 |
| format | Article |
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We evaluated 19 young patients affected by stage I to III lymphomas, referred to our Department for consolidation radiotherapy (RT) treatment on the mediastinum. Patients underwent 2 planning computed tomography (CT) scans performed in different positions: flat standard position and inclined position. A direct comparison between the different treatment plans was carried out analyzing dosimetric parameters obtained from dose-volume histograms generated for each plan. Comparison was performed to evaluate the sparing obtained on breast and heart. Dosimetric evaluation was performed for the following organs at risk (OARs): mammary glands, lungs, and heart. A statistically significant advantage was reported for V5 , V20 , and V30 for the breast when using the inclined board. A similar result was obtained for V5 and V10 on the heart. No advantage was observed in lung doses. The use of a simple device, such as an inclined board, allows the optimization of treatment plan, especially in young female patients, by ensuring a significant reduction of the dose delivered to breast and heart.</description><identifier>ISSN: 0958-3947</identifier><identifier>EISSN: 1873-4022</identifier><identifier>DOI: 10.1016/j.meddos.2016.06.004</identifier><identifier>PMID: 27554205</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Breast dose reduction ; COMPARATIVE EVALUATIONS ; Female ; FEMALES ; HAZARDS ; HEART ; Heart dose reduction ; Hematology, Oncology and Palliative Medicine ; Hodgkin lymphoma ; Humans ; Inclined board ; IRRADIATION ; LUNGS ; Lymphoma - radiotherapy ; LYMPHOMAS ; Male ; MAMMARY GLANDS ; MEDIASTINUM ; Mediastinum - radiation effects ; Non-Hodgkin lymphoma ; OPTIMIZATION ; Organs at Risk ; PATIENTS ; PLANNING ; RADIATION DOSES ; RADIATION PROTECTION AND DOSIMETRY ; Radiology ; RADIOLOGY AND NUCLEAR MEDICINE ; RADIOTHERAPY ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted</subject><ispartof>Medical dosimetry : official journal of the American Association of Medical Dosimetrists, 2016, Vol.41 (4), p.281-284</ispartof><rights>American Association of Medical Dosimetrists</rights><rights>2016 American Association of Medical Dosimetrists</rights><rights>Copyright © 2016 American Association of Medical Dosimetrists. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c394t-223917670f2da92ae0fe71127474f904b98436486ee730142634f6dd4e6984943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0958394716300449$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27554205$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22685160$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Benassi, Michaela, M.D</creatorcontrib><creatorcontrib>Di Murro, Luana, M.D</creatorcontrib><creatorcontrib>Tolu, Barbara, M.D</creatorcontrib><creatorcontrib>Ponti, Elisabetta, M.D</creatorcontrib><creatorcontrib>Falco, Maria Daniela, M.D</creatorcontrib><creatorcontrib>Rossi, Carla, M.D</creatorcontrib><creatorcontrib>Bagalà, Paolo, M.D</creatorcontrib><creatorcontrib>di Cristino, Daniela, M.D</creatorcontrib><creatorcontrib>Murgia, Alessandra, M.D</creatorcontrib><creatorcontrib>Cicchetti, Sara, M.D</creatorcontrib><creatorcontrib>Bruni, Claudia, M.D</creatorcontrib><creatorcontrib>Morelli, Pasquale, M.D</creatorcontrib><creatorcontrib>Lancia, Andrea, M.D</creatorcontrib><creatorcontrib>Santoni, Riccardo, M.D</creatorcontrib><title>Technical solutions to reduce mediastinal irradiation in young patients undergoing treatment for lymphomas: Preliminary experience</title><title>Medical dosimetry : official journal of the American Association of Medical Dosimetrists</title><addtitle>Med Dosim</addtitle><description>Abstract This study aims at optimizing treatment planning in young patients affected by lymphoma (Stage II to III) by using an inclined board (IB) that allows reducing doses to the organs at risk. We evaluated 19 young patients affected by stage I to III lymphomas, referred to our Department for consolidation radiotherapy (RT) treatment on the mediastinum. Patients underwent 2 planning computed tomography (CT) scans performed in different positions: flat standard position and inclined position. A direct comparison between the different treatment plans was carried out analyzing dosimetric parameters obtained from dose-volume histograms generated for each plan. Comparison was performed to evaluate the sparing obtained on breast and heart. Dosimetric evaluation was performed for the following organs at risk (OARs): mammary glands, lungs, and heart. A statistically significant advantage was reported for V5 , V20 , and V30 for the breast when using the inclined board. A similar result was obtained for V5 and V10 on the heart. No advantage was observed in lung doses. The use of a simple device, such as an inclined board, allows the optimization of treatment plan, especially in young female patients, by ensuring a significant reduction of the dose delivered to breast and heart.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Breast dose reduction</subject><subject>COMPARATIVE EVALUATIONS</subject><subject>Female</subject><subject>FEMALES</subject><subject>HAZARDS</subject><subject>HEART</subject><subject>Heart dose reduction</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Hodgkin lymphoma</subject><subject>Humans</subject><subject>Inclined board</subject><subject>IRRADIATION</subject><subject>LUNGS</subject><subject>Lymphoma - radiotherapy</subject><subject>LYMPHOMAS</subject><subject>Male</subject><subject>MAMMARY GLANDS</subject><subject>MEDIASTINUM</subject><subject>Mediastinum - radiation effects</subject><subject>Non-Hodgkin lymphoma</subject><subject>OPTIMIZATION</subject><subject>Organs at Risk</subject><subject>PATIENTS</subject><subject>PLANNING</subject><subject>RADIATION DOSES</subject><subject>RADIATION PROTECTION AND DOSIMETRY</subject><subject>Radiology</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RADIOTHERAPY</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy Planning, Computer-Assisted</subject><issn>0958-3947</issn><issn>1873-4022</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUl2L1TAQDaK4d1f_gUjAF196zVfTxgdhWVwVFhRcn0M3ne7m2iY1ScX76i93alcffBEGwsyc-ThzQsgzzvaccf3qsJ-g72PeC_T2DI2pB2TH20ZWignxkOyYqdtKGtWckNOcD4yxWjH5mJyIpq6VYPWO_LwGdxe860aa47gUH0OmJdIE_eKA4gjf5eID5n1KHXorhPpAj3EJt3RGH0LJdAk9pNvoMVYSdGXCKB1iouNxmu_i1OXX9FOC0U_YLB0p_JghYamDJ-TR0I0Znt6_Z-TL5dvri_fV1cd3Hy7OryqHFEolhDS80Q0bRN8Z0QEboOFcNKpRg2HqxrRKatVqgEYyroSWatB9r0Bjxih5Rl5sfSMSstn5gtRdDAFcsULotuaaIerlhppT_LZALnby2cE4dgHiki1vcQ2ujGkRqjaoSzHnBIOdk5-QnOXMrhrZg900sqtGlqGxdY_n9xOWG0z_LfojCgLebADAa3z3kNZl10v1Pq279tH_b8K_Ddzof4v8FY6QD3FJKChysVlYZj-v_2T9JlxLLFdG_gKg67qu</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Benassi, Michaela, M.D</creator><creator>Di Murro, Luana, M.D</creator><creator>Tolu, Barbara, M.D</creator><creator>Ponti, Elisabetta, M.D</creator><creator>Falco, Maria Daniela, M.D</creator><creator>Rossi, Carla, M.D</creator><creator>Bagalà, Paolo, M.D</creator><creator>di Cristino, Daniela, M.D</creator><creator>Murgia, Alessandra, M.D</creator><creator>Cicchetti, Sara, M.D</creator><creator>Bruni, Claudia, M.D</creator><creator>Morelli, Pasquale, M.D</creator><creator>Lancia, Andrea, M.D</creator><creator>Santoni, Riccardo, M.D</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>2016</creationdate><title>Technical solutions to reduce mediastinal irradiation in young patients undergoing treatment for lymphomas: Preliminary experience</title><author>Benassi, Michaela, M.D ; Di Murro, Luana, M.D ; Tolu, Barbara, M.D ; Ponti, Elisabetta, M.D ; Falco, Maria Daniela, M.D ; Rossi, Carla, M.D ; Bagalà, Paolo, M.D ; di Cristino, Daniela, M.D ; Murgia, Alessandra, M.D ; Cicchetti, Sara, M.D ; Bruni, Claudia, M.D ; Morelli, Pasquale, M.D ; Lancia, Andrea, M.D ; Santoni, Riccardo, M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-223917670f2da92ae0fe71127474f904b98436486ee730142634f6dd4e6984943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Breast dose reduction</topic><topic>COMPARATIVE EVALUATIONS</topic><topic>Female</topic><topic>FEMALES</topic><topic>HAZARDS</topic><topic>HEART</topic><topic>Heart dose reduction</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Hodgkin lymphoma</topic><topic>Humans</topic><topic>Inclined board</topic><topic>IRRADIATION</topic><topic>LUNGS</topic><topic>Lymphoma - radiotherapy</topic><topic>LYMPHOMAS</topic><topic>Male</topic><topic>MAMMARY GLANDS</topic><topic>MEDIASTINUM</topic><topic>Mediastinum - radiation effects</topic><topic>Non-Hodgkin lymphoma</topic><topic>OPTIMIZATION</topic><topic>Organs at Risk</topic><topic>PATIENTS</topic><topic>PLANNING</topic><topic>RADIATION DOSES</topic><topic>RADIATION PROTECTION AND DOSIMETRY</topic><topic>Radiology</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>RADIOTHERAPY</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy Planning, Computer-Assisted</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Benassi, Michaela, M.D</creatorcontrib><creatorcontrib>Di Murro, Luana, M.D</creatorcontrib><creatorcontrib>Tolu, Barbara, M.D</creatorcontrib><creatorcontrib>Ponti, Elisabetta, M.D</creatorcontrib><creatorcontrib>Falco, Maria Daniela, M.D</creatorcontrib><creatorcontrib>Rossi, Carla, M.D</creatorcontrib><creatorcontrib>Bagalà, Paolo, M.D</creatorcontrib><creatorcontrib>di Cristino, Daniela, M.D</creatorcontrib><creatorcontrib>Murgia, Alessandra, M.D</creatorcontrib><creatorcontrib>Cicchetti, Sara, M.D</creatorcontrib><creatorcontrib>Bruni, Claudia, M.D</creatorcontrib><creatorcontrib>Morelli, Pasquale, M.D</creatorcontrib><creatorcontrib>Lancia, Andrea, M.D</creatorcontrib><creatorcontrib>Santoni, Riccardo, M.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Medical dosimetry : official journal of the American Association of Medical Dosimetrists</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Benassi, Michaela, M.D</au><au>Di Murro, Luana, M.D</au><au>Tolu, Barbara, M.D</au><au>Ponti, Elisabetta, M.D</au><au>Falco, Maria Daniela, M.D</au><au>Rossi, Carla, M.D</au><au>Bagalà, Paolo, M.D</au><au>di Cristino, Daniela, M.D</au><au>Murgia, Alessandra, M.D</au><au>Cicchetti, Sara, M.D</au><au>Bruni, Claudia, M.D</au><au>Morelli, Pasquale, M.D</au><au>Lancia, Andrea, M.D</au><au>Santoni, Riccardo, M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Technical solutions to reduce mediastinal irradiation in young patients undergoing treatment for lymphomas: Preliminary experience</atitle><jtitle>Medical dosimetry : official journal of the American Association of Medical Dosimetrists</jtitle><addtitle>Med Dosim</addtitle><date>2016</date><risdate>2016</risdate><volume>41</volume><issue>4</issue><spage>281</spage><epage>284</epage><pages>281-284</pages><issn>0958-3947</issn><eissn>1873-4022</eissn><abstract>Abstract This study aims at optimizing treatment planning in young patients affected by lymphoma (Stage II to III) by using an inclined board (IB) that allows reducing doses to the organs at risk. We evaluated 19 young patients affected by stage I to III lymphomas, referred to our Department for consolidation radiotherapy (RT) treatment on the mediastinum. Patients underwent 2 planning computed tomography (CT) scans performed in different positions: flat standard position and inclined position. A direct comparison between the different treatment plans was carried out analyzing dosimetric parameters obtained from dose-volume histograms generated for each plan. Comparison was performed to evaluate the sparing obtained on breast and heart. Dosimetric evaluation was performed for the following organs at risk (OARs): mammary glands, lungs, and heart. A statistically significant advantage was reported for V5 , V20 , and V30 for the breast when using the inclined board. A similar result was obtained for V5 and V10 on the heart. No advantage was observed in lung doses. The use of a simple device, such as an inclined board, allows the optimization of treatment plan, especially in young female patients, by ensuring a significant reduction of the dose delivered to breast and heart.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27554205</pmid><doi>10.1016/j.meddos.2016.06.004</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Breast dose reduction COMPARATIVE EVALUATIONS Female FEMALES HAZARDS HEART Heart dose reduction Hematology, Oncology and Palliative Medicine Hodgkin lymphoma Humans Inclined board IRRADIATION LUNGS Lymphoma - radiotherapy LYMPHOMAS Male MAMMARY GLANDS MEDIASTINUM Mediastinum - radiation effects Non-Hodgkin lymphoma OPTIMIZATION Organs at Risk PATIENTS PLANNING RADIATION DOSES RADIATION PROTECTION AND DOSIMETRY Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted |
| title | Technical solutions to reduce mediastinal irradiation in young patients undergoing treatment for lymphomas: Preliminary experience |
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