Dissociative electron attachment to the radiosensitizing chemotherapeutic agent hydroxyurea
Dissociative electron attachment to hydroxyurea was studied in the gas phase for electron energies ranging from zero to 9 eV in order to probe its radiosensitizing capabilities. The experiments were carried out using a hemispherical electron monochromator coupled with a quadrupole mass spectrometer....
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| Veröffentlicht in: | The Journal of chemical physics 2016-06, Vol.144 (22), p.224309-224309 |
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| container_issue | 22 |
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| container_title | The Journal of chemical physics |
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| creator | Huber, S. E. Śmiałek, M. A. Tanzer, K. Denifl, S. |
| description | Dissociative electron attachment to hydroxyurea was studied in the gas phase for electron energies ranging from zero to 9 eV in order to probe its radiosensitizing capabilities. The experiments were carried out using a hemispherical electron monochromator coupled with a quadrupole mass spectrometer. Diversified fragmentation of hydroxyurea was observed upon low energy electron attachment and here we highlight the major dissociation channels. Moreover, thermodynamic thresholds for various fragmentation reactions are reported to support the discussion of the experimental findings. The dominant dissociation channel, which was observed over a broad range of energies, is associated with formation of NCO−, water, and the amidogen (NH2) radical. The second and third most dominant dissociation channels are associated with formation of NCNH− and NHCONH2
−, respectively, which are both directly related to formation of the highly reactive hydroxyl radical. Other ions observed with significant abundance in the mass spectra were NH2
−/O−, OH−, CN−, HNOH−, NCONH2
−, and ONHCONH2
−. |
| doi_str_mv | 10.1063/1.4953579 |
| format | Article |
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−, respectively, which are both directly related to formation of the highly reactive hydroxyl radical. Other ions observed with significant abundance in the mass spectra were NH2
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−, respectively, which are both directly related to formation of the highly reactive hydroxyl radical. Other ions observed with significant abundance in the mass spectra were NH2
−/O−, OH−, CN−, HNOH−, NCONH2
−, and ONHCONH2
−.</description><subject>Channels</subject><subject>CHEMOTHERAPY</subject><subject>DISSOCIATION</subject><subject>ELECTRON ATTACHMENT</subject><subject>Electrons</subject><subject>EXPERIMENTAL DATA</subject><subject>Fragmentation</subject><subject>Free Radicals - chemistry</subject><subject>HYDROXYL RADICALS</subject><subject>HYDROXYUREA</subject><subject>Hydroxyurea - chemistry</subject><subject>INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY</subject><subject>MASS SPECTRA</subject><subject>Mass Spectrometry</subject><subject>Models, Chemical</subject><subject>Physics</subject><subject>Quadrupoles</subject><subject>Quantum Theory</subject><subject>Radiation-Sensitizing Agents - chemistry</subject><issn>0021-9606</issn><issn>1089-7690</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90U1v1DAQBmALUdGlcOAPoEhcACllxk7i-IjKp1Spl_bEwfI648bVJl5sp2L59Xi1S3uCkw_z6NWMX8ZeIZwjdOIDnjeqFa1UT9gKoVe17BQ8ZSsAjrXqoDtlz1O6AwCUvHnGTrkU0AGoFfvxyacUrDfZ31NFG7I5hrkyORs7TjTnKocqj1RFM_iQaE4--99-vq3sSFMok2i2tGRvK3O75-NuiOHXbolkXrATZzaJXh7fM3bz5fP1xbf68urr94uPl7VtEHNNqoEBW9HLFiUI1zveOLOWrkXOTecQLUfBEQTn0kkx2H4NrUUAMQyqIXHG3hxyQ8peJ-sz2dGGeS7HaM67Dsq5Rb09qG0MPxdKWU8-WdpszExhSRqlkn35OMEfAx_oXVjiXG7QHHlZUjWtLOrdQdkYUork9Db6ycSdRtD7XjTqYy_Fvj4mLuuJhgf5t4gC3h_Afv1SRpj_m_ZPfB_iI9TbwYk_3XmjCg</recordid><startdate>20160614</startdate><enddate>20160614</enddate><creator>Huber, S. E.</creator><creator>Śmiałek, M. A.</creator><creator>Tanzer, K.</creator><creator>Denifl, S.</creator><general>American Institute of Physics</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope><scope>7X8</scope><scope>OTOTI</scope><orcidid>https://orcid.org/0000-0002-7387-226X</orcidid></search><sort><creationdate>20160614</creationdate><title>Dissociative electron attachment to the radiosensitizing chemotherapeutic agent hydroxyurea</title><author>Huber, S. E. ; Śmiałek, M. A. ; Tanzer, K. ; Denifl, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-e940d1538751703f8f24fab7f5122a6f11c2132103227f73dc8b05c1003dd94e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Channels</topic><topic>CHEMOTHERAPY</topic><topic>DISSOCIATION</topic><topic>ELECTRON ATTACHMENT</topic><topic>Electrons</topic><topic>EXPERIMENTAL DATA</topic><topic>Fragmentation</topic><topic>Free Radicals - chemistry</topic><topic>HYDROXYL RADICALS</topic><topic>HYDROXYUREA</topic><topic>Hydroxyurea - chemistry</topic><topic>INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY</topic><topic>MASS SPECTRA</topic><topic>Mass Spectrometry</topic><topic>Models, Chemical</topic><topic>Physics</topic><topic>Quadrupoles</topic><topic>Quantum Theory</topic><topic>Radiation-Sensitizing Agents - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huber, S. E.</creatorcontrib><creatorcontrib>Śmiałek, M. A.</creatorcontrib><creatorcontrib>Tanzer, K.</creatorcontrib><creatorcontrib>Denifl, S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>The Journal of chemical physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huber, S. E.</au><au>Śmiałek, M. A.</au><au>Tanzer, K.</au><au>Denifl, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dissociative electron attachment to the radiosensitizing chemotherapeutic agent hydroxyurea</atitle><jtitle>The Journal of chemical physics</jtitle><addtitle>J Chem Phys</addtitle><date>2016-06-14</date><risdate>2016</risdate><volume>144</volume><issue>22</issue><spage>224309</spage><epage>224309</epage><pages>224309-224309</pages><issn>0021-9606</issn><eissn>1089-7690</eissn><coden>JCPSA6</coden><abstract>Dissociative electron attachment to hydroxyurea was studied in the gas phase for electron energies ranging from zero to 9 eV in order to probe its radiosensitizing capabilities. The experiments were carried out using a hemispherical electron monochromator coupled with a quadrupole mass spectrometer. Diversified fragmentation of hydroxyurea was observed upon low energy electron attachment and here we highlight the major dissociation channels. Moreover, thermodynamic thresholds for various fragmentation reactions are reported to support the discussion of the experimental findings. The dominant dissociation channel, which was observed over a broad range of energies, is associated with formation of NCO−, water, and the amidogen (NH2) radical. The second and third most dominant dissociation channels are associated with formation of NCNH− and NHCONH2
−, respectively, which are both directly related to formation of the highly reactive hydroxyl radical. Other ions observed with significant abundance in the mass spectra were NH2
−/O−, OH−, CN−, HNOH−, NCONH2
−, and ONHCONH2
−.</abstract><cop>United States</cop><pub>American Institute of Physics</pub><pmid>27306009</pmid><doi>10.1063/1.4953579</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7387-226X</orcidid></addata></record> |
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| language | eng |
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| subjects | Channels CHEMOTHERAPY DISSOCIATION ELECTRON ATTACHMENT Electrons EXPERIMENTAL DATA Fragmentation Free Radicals - chemistry HYDROXYL RADICALS HYDROXYUREA Hydroxyurea - chemistry INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY MASS SPECTRA Mass Spectrometry Models, Chemical Physics Quadrupoles Quantum Theory Radiation-Sensitizing Agents - chemistry |
| title | Dissociative electron attachment to the radiosensitizing chemotherapeutic agent hydroxyurea |
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