Brain Metastasis Velocity: A Novel Prognostic Metric Predictive of Overall Survival and Freedom From Whole-Brain Radiation Therapy After Distant Brain Failure Following Upfront Radiosurgery Alone

Prior statistical models attempted to identify risk factors for time to distant brain failure (DBF) or time to salvage whole-brain radiation therapy (WBRT) to predict the benefit of early WBRT versus stereotactic radiosurgery (SRS) alone. We introduce a novel clinical metric, brain metastasis veloci...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2017-05, Vol.98 (1), p.131-141
Hauptverfasser:	Farris, Michael, McTyre, Emory R., Cramer, Christina K., Hughes, Ryan, Randolph, David M., Ayala-Peacock, Diandra N., Bourland, J. Daniel, Ruiz, Jimmy, Watabe, Kounosuke, Laxton, Adrian W., Tatter, Stephen B., Zhou, Xiaobo, Chan, Michael D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Analysis of Variance BRAIN Brain Death Brain Neoplasms - classification Brain Neoplasms - mortality Brain Neoplasms - radiotherapy Brain Neoplasms - secondary Breast Neoplasms Carcinoma, Renal Cell - radiotherapy Carcinoma, Renal Cell - secondary Confidence Intervals Cranial Irradiation - statistics & numerical data Female Humans Kidney Neoplasms Lung Neoplasms Male Melanoma - radiotherapy Melanoma - secondary METRICS Middle Aged MULTIVARIATE ANALYSIS NEOPLASMS Prognosis RADIOLOGY AND NUCLEAR MEDICINE Radiosurgery - methods RADIOTHERAPY Retrospective Studies Risk Factors Salvage Therapy - methods Salvage Therapy - statistics & numerical data STATISTICAL MODELS SURGERY SURVIVAL TIME Time Factors Treatment Outcome
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