Downregulation of miR-199b promotes the acute spinal cord injury through IKKβ-NF-κB signaling pathway activating microglial cells

Inflammatory response played an important role in the progression of spinal cord injury (SCI). Several miRNAs were associated with the pathology of SCI. However, the molecular mechanism of miRNA involving in inflammatory response in acute SCI (ASCI) was poorly understood. Sprague-Dawley (SD) rats we...

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Veröffentlicht in:	Experimental cell research 2016-11, Vol.349 (1), p.60-67
Hauptverfasser:	Zhou, Heng-Jun, Wang, Li-Qing, Xu, Qing-Sheng, Fan, Zuo-Xu, Zhu, Yu, Jiang, Hao, Zheng, Xiu-Jue, Ma, Yue-Hui, Zhan, Ren-Ya
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Acute Disease Animals Down-Regulation Female I-kappa B Kinase - metabolism IKKβ-NF-κB signaling pathway INFLAMMATION Inflammation - pathology INJURIES LIPOPOLYSACCHARIDES LUCIFERASE LYMPHOKINES Mice Microglia Microglia - metabolism Microglia - pathology MicroRNAs - genetics MicroRNAs - metabolism MiR-199b NECROSIS NEOPLASMS NF-kappa B - metabolism PATHOLOGY PHOSPHOTRANSFERASES POLYMERASE CHAIN REACTION RATS Rats, Sprague-Dawley Signal Transduction SPINAL CORD Spinal Cord Injuries - genetics Spinal Cord Injuries - pathology Spinal cord injury TRANSCRIPTION Transcription Factor RelA - metabolism Up-Regulation - genetics
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