Using [18 F]Fluorothymidine Imaged With Positron Emission Tomography to Quantify and Reduce Hematologic Toxicity Due to Chemoradiation Therapy for Pelvic Cancer Patients

Purpose The purpose of the present prospective clinical trial was to determine the efficacy of [18 F]fluorothymidine (FLT)-identified active bone marrow sparing for pelvic cancer patients by correlating the FLT uptake change during and after chemoradiation therapy with hematologic toxicity. Methods...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2016-09, Vol.96 (1), p.228-239
Hauptverfasser:	McGuire, Sarah M., PhD, Bhatia, Sudershan K., MD, Sun, Wenqing, MD, Jacobson, Geraldine M., MD, MPH, MBA, Menda, Yusuf, MD, Ponto, Laura L., PhD, Smith, Brian J., PhD, Gross, Brandie A., CMD, Bayouth, John E., PhD, Sunderland, John J., PhD, Graham, Michael M., MD, PhD, Buatti, John M., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged BIOMEDICAL RADIOGRAPHY BLOOD COUNT BONE MARROW Chemoradiotherapy - adverse effects CHEMOTHERAPY CLINICAL TRIALS Dideoxynucleosides EMISSION Female FLUORINE 18 GY RANGE 01-10 GY RANGE 10-100 Hematologic Diseases - diagnostic imaging Hematologic Diseases - etiology Hematologic Diseases - prevention & control Hematology, Oncology and Palliative Medicine Humans Male Middle Aged NEOPLASMS PATIENTS Pelvic Neoplasms - diagnostic imaging Pelvic Neoplasms - therapy POSITRON COMPUTED TOMOGRAPHY Positron-Emission Tomography - methods RADIATION DOSES Radiation Injuries - diagnostic imaging Radiation Injuries - etiology Radiation Injuries - prevention & control Radiation Protection - methods Radiology RADIOLOGY AND NUCLEAR MEDICINE Radiopharmaceuticals RADIOTHERAPY Radiotherapy Dosage Radiotherapy, Image-Guided - methods Reproducibility of Results Sensitivity and Specificity TOXICITY
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