Monitoring Tumor Response to Carbogen Breathing by Oxygen-Sensitive Magnetic Resonance Parameters to Predict the Outcome of Radiation Therapy: A Preclinical Study
Purpose In an effort to develop noninvasive in vivo methods for mapping tumor oxygenation, magnetic resonance (MR)-derived parameters are being considered, including global R1 , water R1 , lipids R1 , and R2 *. R1 is sensitive to dissolved molecular oxygen, whereas R2 * is sensitive to blood oxygena...
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| creator | Cao-Pham, Thanh-Trang, BSc Tran, Ly-Binh-An, PhD Colliez, Florence, PhD Joudiou, Nicolas, PhD El Bachiri, Sabrina, PhD Grégoire, Vincent, PhD Levêque, Philippe, PhD Gallez, Bernard, PhD Jordan, Bénédicte F., PhD |
| description | Purpose In an effort to develop noninvasive in vivo methods for mapping tumor oxygenation, magnetic resonance (MR)-derived parameters are being considered, including global R1 , water R1 , lipids R1 , and R2 *. R1 is sensitive to dissolved molecular oxygen, whereas R2 * is sensitive to blood oxygenation, detecting changes in dHb. This work compares global R1 , water R1 , lipids R1 , and R2 * with pO2 assessed by electron paramagnetic resonance (EPR) oximetry, as potential markers of the outcome of radiation therapy (RT). Methods and Materials R1 , R2 *, and EPR were performed on rhabdomyosarcoma and 9L-glioma tumor models, under air and carbogen breathing conditions (95% O2 , 5% CO2 ). Because the models demonstrated different radiosensitivity properties toward carbogen, a growth delay (GD) assay was performed on the rhabdomyosarcoma model and a tumor control dose 50% (TCD50) was performed on the 9L-glioma model. Results Magnetic resonance imaging oxygen-sensitive parameters detected the positive changes in oxygenation induced by carbogen within tumors. No consistent correlation was seen throughout the study between MR parameters and pO2 . Global and lipids R1 were found to be correlated to pO2 in the rhabdomyosarcoma model, whereas R2 * was found to be inversely correlated to pO2 in the 9L-glioma model ( P =.05 and .03). Carbogen increased the TCD50 of 9L-glioma but did not increase the GD of rhabdomyosarcoma. Only R2 * was predictive ( P |
| doi_str_mv | 10.1016/j.ijrobp.2016.04.029 |
| format | Article |
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R1 is sensitive to dissolved molecular oxygen, whereas R2 * is sensitive to blood oxygenation, detecting changes in dHb. This work compares global R1 , water R1 , lipids R1 , and R2 * with pO2 assessed by electron paramagnetic resonance (EPR) oximetry, as potential markers of the outcome of radiation therapy (RT). Methods and Materials R1 , R2 *, and EPR were performed on rhabdomyosarcoma and 9L-glioma tumor models, under air and carbogen breathing conditions (95% O2 , 5% CO2 ). Because the models demonstrated different radiosensitivity properties toward carbogen, a growth delay (GD) assay was performed on the rhabdomyosarcoma model and a tumor control dose 50% (TCD50) was performed on the 9L-glioma model. Results Magnetic resonance imaging oxygen-sensitive parameters detected the positive changes in oxygenation induced by carbogen within tumors. No consistent correlation was seen throughout the study between MR parameters and pO2 . Global and lipids R1 were found to be correlated to pO2 in the rhabdomyosarcoma model, whereas R2 * was found to be inversely correlated to pO2 in the 9L-glioma model ( P =.05 and .03). Carbogen increased the TCD50 of 9L-glioma but did not increase the GD of rhabdomyosarcoma. Only R2 * was predictive ( P <.05) for the curability of 9L-glioma at 40 Gy, a dose that showed a difference in response to RT between carbogen and air-breathing groups.18 F-FAZA positron emission tomography imaging has been shown to be a predictive marker under the same conditions. Conclusion This work illustrates the sensitivity of oxygen-sensitive R1 and R2 * parameters to changes in tumor oxygenation. However, R1 parameters showed limitations in terms of predicting the outcome of RT in the tumor models studied, whereas R2 * was found to be correlated with the outcome in the responsive model.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/j.ijrobp.2016.04.029</identifier><identifier>PMID: 27511852</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Administration, Inhalation ; Animals ; Biomarkers, Tumor - metabolism ; BIOMEDICAL RADIOGRAPHY ; Carbon Dioxide ; Cell Line, Tumor ; CONNECTIVE TISSUE ; ELECTRON SPIN RESONANCE ; GY RANGE 10-100 ; Hematology, Oncology and Palliative Medicine ; IN VIVO ; LIPIDS ; Magnetic Resonance Imaging - methods ; Male ; Molecular Imaging - methods ; Neoplasms, Experimental - diagnosis ; Neoplasms, Experimental - metabolism ; Neoplasms, Experimental - radiotherapy ; NMR IMAGING ; Oxygen - metabolism ; PARTIAL PRESSURE ; POSITRON COMPUTED TOMOGRAPHY ; Prognosis ; Radiology ; RADIOLOGY AND NUCLEAR MEDICINE ; RADIOSENSITIVITY ; RADIOTHERAPY ; Rats ; Rats, Inbred F344 ; Reproducibility of Results ; RESPIRATION ; RHABDOMYOSARCOMAS ; Sensitivity and Specificity ; Treatment Outcome ; Tumor Hypoxia</subject><ispartof>International journal of radiation oncology, biology, physics, 2016-09, Vol.96 (1), p.149-160</ispartof><rights>Elsevier Inc.</rights><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-77fccf556ae93e5f5116b60d1e15dba9880b57403251b7d48087bcca17881bfa3</citedby><cites>FETCH-LOGICAL-c445t-77fccf556ae93e5f5116b60d1e15dba9880b57403251b7d48087bcca17881bfa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijrobp.2016.04.029$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27511852$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22648792$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Cao-Pham, Thanh-Trang, BSc</creatorcontrib><creatorcontrib>Tran, Ly-Binh-An, PhD</creatorcontrib><creatorcontrib>Colliez, Florence, PhD</creatorcontrib><creatorcontrib>Joudiou, Nicolas, PhD</creatorcontrib><creatorcontrib>El Bachiri, Sabrina, PhD</creatorcontrib><creatorcontrib>Grégoire, Vincent, PhD</creatorcontrib><creatorcontrib>Levêque, Philippe, PhD</creatorcontrib><creatorcontrib>Gallez, Bernard, PhD</creatorcontrib><creatorcontrib>Jordan, Bénédicte F., PhD</creatorcontrib><title>Monitoring Tumor Response to Carbogen Breathing by Oxygen-Sensitive Magnetic Resonance Parameters to Predict the Outcome of Radiation Therapy: A Preclinical Study</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Purpose In an effort to develop noninvasive in vivo methods for mapping tumor oxygenation, magnetic resonance (MR)-derived parameters are being considered, including global R1 , water R1 , lipids R1 , and R2 *. R1 is sensitive to dissolved molecular oxygen, whereas R2 * is sensitive to blood oxygenation, detecting changes in dHb. This work compares global R1 , water R1 , lipids R1 , and R2 * with pO2 assessed by electron paramagnetic resonance (EPR) oximetry, as potential markers of the outcome of radiation therapy (RT). Methods and Materials R1 , R2 *, and EPR were performed on rhabdomyosarcoma and 9L-glioma tumor models, under air and carbogen breathing conditions (95% O2 , 5% CO2 ). Because the models demonstrated different radiosensitivity properties toward carbogen, a growth delay (GD) assay was performed on the rhabdomyosarcoma model and a tumor control dose 50% (TCD50) was performed on the 9L-glioma model. Results Magnetic resonance imaging oxygen-sensitive parameters detected the positive changes in oxygenation induced by carbogen within tumors. No consistent correlation was seen throughout the study between MR parameters and pO2 . Global and lipids R1 were found to be correlated to pO2 in the rhabdomyosarcoma model, whereas R2 * was found to be inversely correlated to pO2 in the 9L-glioma model ( P =.05 and .03). Carbogen increased the TCD50 of 9L-glioma but did not increase the GD of rhabdomyosarcoma. Only R2 * was predictive ( P <.05) for the curability of 9L-glioma at 40 Gy, a dose that showed a difference in response to RT between carbogen and air-breathing groups.18 F-FAZA positron emission tomography imaging has been shown to be a predictive marker under the same conditions. Conclusion This work illustrates the sensitivity of oxygen-sensitive R1 and R2 * parameters to changes in tumor oxygenation. However, R1 parameters showed limitations in terms of predicting the outcome of RT in the tumor models studied, whereas R2 * was found to be correlated with the outcome in the responsive model.</description><subject>Administration, Inhalation</subject><subject>Animals</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>BIOMEDICAL RADIOGRAPHY</subject><subject>Carbon Dioxide</subject><subject>Cell Line, Tumor</subject><subject>CONNECTIVE TISSUE</subject><subject>ELECTRON SPIN RESONANCE</subject><subject>GY RANGE 10-100</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>IN VIVO</subject><subject>LIPIDS</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Molecular Imaging - methods</subject><subject>Neoplasms, Experimental - diagnosis</subject><subject>Neoplasms, Experimental - metabolism</subject><subject>Neoplasms, Experimental - radiotherapy</subject><subject>NMR IMAGING</subject><subject>Oxygen - metabolism</subject><subject>PARTIAL PRESSURE</subject><subject>POSITRON COMPUTED TOMOGRAPHY</subject><subject>Prognosis</subject><subject>Radiology</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RADIOSENSITIVITY</subject><subject>RADIOTHERAPY</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Reproducibility of Results</subject><subject>RESPIRATION</subject><subject>RHABDOMYOSARCOMAS</subject><subject>Sensitivity and Specificity</subject><subject>Treatment Outcome</subject><subject>Tumor Hypoxia</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkstu1DAUhiMEotPCGyBkiQ2bDD5JHCcskMqIm9Rqqs4gsbMc52TGw8QOtlM1r8OT4mhaFmzY2LL9nYv__yTJK6BLoFC-Oyz1wdlmWGbxtKTFkmb1k2QBFa_TnLEfT5MFzUua5vH5LDn3_kApBeDF8-Qs4wygYtki-X1tjQ7WabMj27G3jtyiH6zxSIIlK-kau0NDPjqUYT9DzUTW91O8SzdovA76Dsm13BkMWs2x1kijkNxIJ3sM6Pyc58Zhq1UgYY9kPQZleyS2I7ey1TJoa8h2j04O03tyObPqqI1W8kg2YWynF8mzTh49vnzYL5Lvnz9tV1_Tq_WXb6vLq1QVBQsp551SHWOlxDpH1sUflk1JW0BgbSPrqqIN4wXNMwYNb4uKVrxRSgKvKmg6mV8kb055rQ9aeKUDqr2yxqAKIsvKIiqbRertiRqc_TWiD6LXXuHxKA3a0QuoALI651BFtDihylnvHXZicLqXbhJAxeyhOIiTh2L2UNBCRA9j2OuHCmPTY_s36NG0CHw4ARjVuNPo5mYxqt5qN_faWv2_Cv8meFT8J07oD3Z0JiotQPhMULGZ52geIyjjymvI_wDPo8Ye</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Cao-Pham, Thanh-Trang, BSc</creator><creator>Tran, Ly-Binh-An, PhD</creator><creator>Colliez, Florence, PhD</creator><creator>Joudiou, Nicolas, PhD</creator><creator>El Bachiri, Sabrina, PhD</creator><creator>Grégoire, Vincent, PhD</creator><creator>Levêque, Philippe, PhD</creator><creator>Gallez, Bernard, PhD</creator><creator>Jordan, Bénédicte F., PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>20160901</creationdate><title>Monitoring Tumor Response to Carbogen Breathing by Oxygen-Sensitive Magnetic Resonance Parameters to Predict the Outcome of Radiation Therapy: A Preclinical Study</title><author>Cao-Pham, Thanh-Trang, BSc ; Tran, Ly-Binh-An, PhD ; Colliez, Florence, PhD ; Joudiou, Nicolas, PhD ; El Bachiri, Sabrina, PhD ; Grégoire, Vincent, PhD ; Levêque, Philippe, PhD ; Gallez, Bernard, PhD ; Jordan, Bénédicte F., PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-77fccf556ae93e5f5116b60d1e15dba9880b57403251b7d48087bcca17881bfa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Administration, Inhalation</topic><topic>Animals</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>BIOMEDICAL RADIOGRAPHY</topic><topic>Carbon Dioxide</topic><topic>Cell Line, Tumor</topic><topic>CONNECTIVE TISSUE</topic><topic>ELECTRON SPIN RESONANCE</topic><topic>GY RANGE 10-100</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>IN VIVO</topic><topic>LIPIDS</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Molecular Imaging - methods</topic><topic>Neoplasms, Experimental - diagnosis</topic><topic>Neoplasms, Experimental - metabolism</topic><topic>Neoplasms, Experimental - radiotherapy</topic><topic>NMR IMAGING</topic><topic>Oxygen - metabolism</topic><topic>PARTIAL PRESSURE</topic><topic>POSITRON COMPUTED TOMOGRAPHY</topic><topic>Prognosis</topic><topic>Radiology</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>RADIOSENSITIVITY</topic><topic>RADIOTHERAPY</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Reproducibility of Results</topic><topic>RESPIRATION</topic><topic>RHABDOMYOSARCOMAS</topic><topic>Sensitivity and Specificity</topic><topic>Treatment Outcome</topic><topic>Tumor Hypoxia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cao-Pham, Thanh-Trang, BSc</creatorcontrib><creatorcontrib>Tran, Ly-Binh-An, PhD</creatorcontrib><creatorcontrib>Colliez, Florence, PhD</creatorcontrib><creatorcontrib>Joudiou, Nicolas, PhD</creatorcontrib><creatorcontrib>El Bachiri, Sabrina, PhD</creatorcontrib><creatorcontrib>Grégoire, Vincent, PhD</creatorcontrib><creatorcontrib>Levêque, Philippe, PhD</creatorcontrib><creatorcontrib>Gallez, Bernard, PhD</creatorcontrib><creatorcontrib>Jordan, Bénédicte F., PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cao-Pham, Thanh-Trang, BSc</au><au>Tran, Ly-Binh-An, PhD</au><au>Colliez, Florence, PhD</au><au>Joudiou, Nicolas, PhD</au><au>El Bachiri, Sabrina, PhD</au><au>Grégoire, Vincent, PhD</au><au>Levêque, Philippe, PhD</au><au>Gallez, Bernard, PhD</au><au>Jordan, Bénédicte F., PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Monitoring Tumor Response to Carbogen Breathing by Oxygen-Sensitive Magnetic Resonance Parameters to Predict the Outcome of Radiation Therapy: A Preclinical Study</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>96</volume><issue>1</issue><spage>149</spage><epage>160</epage><pages>149-160</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><abstract>Purpose In an effort to develop noninvasive in vivo methods for mapping tumor oxygenation, magnetic resonance (MR)-derived parameters are being considered, including global R1 , water R1 , lipids R1 , and R2 *. R1 is sensitive to dissolved molecular oxygen, whereas R2 * is sensitive to blood oxygenation, detecting changes in dHb. This work compares global R1 , water R1 , lipids R1 , and R2 * with pO2 assessed by electron paramagnetic resonance (EPR) oximetry, as potential markers of the outcome of radiation therapy (RT). Methods and Materials R1 , R2 *, and EPR were performed on rhabdomyosarcoma and 9L-glioma tumor models, under air and carbogen breathing conditions (95% O2 , 5% CO2 ). Because the models demonstrated different radiosensitivity properties toward carbogen, a growth delay (GD) assay was performed on the rhabdomyosarcoma model and a tumor control dose 50% (TCD50) was performed on the 9L-glioma model. Results Magnetic resonance imaging oxygen-sensitive parameters detected the positive changes in oxygenation induced by carbogen within tumors. No consistent correlation was seen throughout the study between MR parameters and pO2 . Global and lipids R1 were found to be correlated to pO2 in the rhabdomyosarcoma model, whereas R2 * was found to be inversely correlated to pO2 in the 9L-glioma model ( P =.05 and .03). Carbogen increased the TCD50 of 9L-glioma but did not increase the GD of rhabdomyosarcoma. Only R2 * was predictive ( P <.05) for the curability of 9L-glioma at 40 Gy, a dose that showed a difference in response to RT between carbogen and air-breathing groups.18 F-FAZA positron emission tomography imaging has been shown to be a predictive marker under the same conditions. Conclusion This work illustrates the sensitivity of oxygen-sensitive R1 and R2 * parameters to changes in tumor oxygenation. However, R1 parameters showed limitations in terms of predicting the outcome of RT in the tumor models studied, whereas R2 * was found to be correlated with the outcome in the responsive model.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27511852</pmid><doi>10.1016/j.ijrobp.2016.04.029</doi><tpages>12</tpages></addata></record> |
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| ispartof | International journal of radiation oncology, biology, physics, 2016-09, Vol.96 (1), p.149-160 |
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| subjects | Administration, Inhalation Animals Biomarkers, Tumor - metabolism BIOMEDICAL RADIOGRAPHY Carbon Dioxide Cell Line, Tumor CONNECTIVE TISSUE ELECTRON SPIN RESONANCE GY RANGE 10-100 Hematology, Oncology and Palliative Medicine IN VIVO LIPIDS Magnetic Resonance Imaging - methods Male Molecular Imaging - methods Neoplasms, Experimental - diagnosis Neoplasms, Experimental - metabolism Neoplasms, Experimental - radiotherapy NMR IMAGING Oxygen - metabolism PARTIAL PRESSURE POSITRON COMPUTED TOMOGRAPHY Prognosis Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOSENSITIVITY RADIOTHERAPY Rats Rats, Inbred F344 Reproducibility of Results RESPIRATION RHABDOMYOSARCOMAS Sensitivity and Specificity Treatment Outcome Tumor Hypoxia |
| title | Monitoring Tumor Response to Carbogen Breathing by Oxygen-Sensitive Magnetic Resonance Parameters to Predict the Outcome of Radiation Therapy: A Preclinical Study |
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