Analysis of the Factors Contributing to Vertebral Compression Fractures After Spine Stereotactic Radiosurgery
Purpose To determine our institutional vertebral compression fracture (VCF) rate after spine stereotactic radiosurgery (SRS) and determine contributory factors. Methods and Materials Retrospective analysis from 2001 to 2013 at a single institution was performed. With institutional review board appro...
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| creator | Boyce-Fappiano, David, BSc Elibe, Erinma, BS Schultz, Lonni, PhD Ryu, Samuel, MD Siddiqui, M. Salim, MD, PhD Chetty, Indrin, PhD Lee, Ian, MD Rock, Jack, MD Movsas, Benjamin, MD Siddiqui, Farzan, MD, PhD |
| description | Purpose To determine our institutional vertebral compression fracture (VCF) rate after spine stereotactic radiosurgery (SRS) and determine contributory factors. Methods and Materials Retrospective analysis from 2001 to 2013 at a single institution was performed. With institutional review board approval, electronic medical records of 1905 vertebral bodies from 791 patients who were treated with SRS for the management of primary or metastatic spinal lesions were reviewed. A total of 448 patients (1070 vertebral bodies) with adequate follow-up imaging studies available were analyzed. Doses ranging from 10 Gy in 1 fraction to 60 Gy in 5 fractions were delivered. Computed tomography and magnetic resonance imaging were used to evaluate the primary endpoints of this study: development of a new VCF, progression of an existing VCF, and requirement of stabilization surgery after SRS. Results A total of 127 VCFs (11.9%; 95% confidence interval [CI] 9.5%-14.2%) in 97 patients were potentially SRS induced: 46 (36%) were de novo, 44 (35%) VCFs progressed, and 37 (29%) required stabilization surgery after SRS. Our rate for radiologic VCF development/progression (excluding patients who underwent surgery) was 8.4%. Upon further exclusion of patients with hematologic malignancies the VCF rate was 7.6%. In the univariate analyses, females (hazard ratio [HR] 1.54, 95% CI 1.01-2.33, P =.04), prior VCF (HR 1.99, 95% CI 1.30-3.06, P =.001), primary hematologic malignancies (HR 2.68, 95% CI 1.68-4.28, P |
| doi_str_mv | 10.1016/j.ijrobp.2016.09.007 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_22645759</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0360301616331765</els_id><sourcerecordid>1857377394</sourcerecordid><originalsourceid>FETCH-LOGICAL-c445t-27daa141f71d5a234b3d3abbb2a9bb7e1cf9033083ecdbc34197b5543c5570e23</originalsourceid><addsrcrecordid>eNqFks-L1DAUx4so7rj6H4gEvHjpmJ9NexGGYUeFBcFR8RaS9HU3tW1qkgrz35vS1YMXT8njfd7P7yuKlwTvCSbV237v-uDNvKfZ2uNmj7F8VOxILZuSCfH9cbHDrMIly-6r4lmMPcaYEMmfFle0xlVNGd0V42HSwyW6iHyH0j2gk7bJh4iOfkrBmSW56Q4lj75BSGCCHrJnnAPE6PyETiHjS7bQoUsQ0Hl2E6Bz_oJP2eUs-qxb5-MS7iBcnhdPOj1EePHwXhdfTzdfjh_K20_vPx4Pt6XlXKSSylZrwkknSSs0ZdywlmljDNWNMRKI7RrMGK4Z2NZYxkkjjRCcWSEkBsqui9dbXh-TU9G6BPbe-mkCmxSlFRdSNJl6s1Fz8D8XiEmNLloYBj2BX6IitZBMStbwjPINtcHHGKBTc3CjDhdFsFrlUL3a5FCrHAo3KsuRw149VFjMCO3foD_7z8C7DYC8jV8OwtosTBZaF9ZeW-_-V-HfBHZwk7N6-AEXiL1fQhY4z6IiVVid15NYL4JUjBFZCfYb5seztA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1857377394</pqid></control><display><type>article</type><title>Analysis of the Factors Contributing to Vertebral Compression Fractures After Spine Stereotactic Radiosurgery</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Boyce-Fappiano, David, BSc ; Elibe, Erinma, BS ; Schultz, Lonni, PhD ; Ryu, Samuel, MD ; Siddiqui, M. Salim, MD, PhD ; Chetty, Indrin, PhD ; Lee, Ian, MD ; Rock, Jack, MD ; Movsas, Benjamin, MD ; Siddiqui, Farzan, MD, PhD</creator><creatorcontrib>Boyce-Fappiano, David, BSc ; Elibe, Erinma, BS ; Schultz, Lonni, PhD ; Ryu, Samuel, MD ; Siddiqui, M. Salim, MD, PhD ; Chetty, Indrin, PhD ; Lee, Ian, MD ; Rock, Jack, MD ; Movsas, Benjamin, MD ; Siddiqui, Farzan, MD, PhD</creatorcontrib><description>Purpose To determine our institutional vertebral compression fracture (VCF) rate after spine stereotactic radiosurgery (SRS) and determine contributory factors. Methods and Materials Retrospective analysis from 2001 to 2013 at a single institution was performed. With institutional review board approval, electronic medical records of 1905 vertebral bodies from 791 patients who were treated with SRS for the management of primary or metastatic spinal lesions were reviewed. A total of 448 patients (1070 vertebral bodies) with adequate follow-up imaging studies available were analyzed. Doses ranging from 10 Gy in 1 fraction to 60 Gy in 5 fractions were delivered. Computed tomography and magnetic resonance imaging were used to evaluate the primary endpoints of this study: development of a new VCF, progression of an existing VCF, and requirement of stabilization surgery after SRS. Results A total of 127 VCFs (11.9%; 95% confidence interval [CI] 9.5%-14.2%) in 97 patients were potentially SRS induced: 46 (36%) were de novo, 44 (35%) VCFs progressed, and 37 (29%) required stabilization surgery after SRS. Our rate for radiologic VCF development/progression (excluding patients who underwent surgery) was 8.4%. Upon further exclusion of patients with hematologic malignancies the VCF rate was 7.6%. In the univariate analyses, females (hazard ratio [HR] 1.54, 95% CI 1.01-2.33, P =.04), prior VCF (HR 1.99, 95% CI 1.30-3.06, P =.001), primary hematologic malignancies (HR 2.68, 95% CI 1.68-4.28, P <.001), thoracic spine lesions (HR 1.46, 95% CI 1.02-2.10, P =.02), and lytic lesions had a significantly increased risk for VCF after SRS. On multivariate analyses, prior VCF and lesion type remained contributory. Conclusions Single-fraction SRS doses of 16 to 18 Gy to the spine seem to be associated with a low rate of VCFs. To the best of our knowledge, this is the largest reported experience analyzing SRS-induced VCFs, with one of the lowest event rates reported.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/j.ijrobp.2016.09.007</identifier><identifier>PMID: 28068232</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Analysis of Variance ; BIOMEDICAL RADIOGRAPHY ; COMPRESSION ; COMPUTERIZED TOMOGRAPHY ; Confidence Intervals ; Disease Progression ; Female ; Fracture Fixation - methods ; Fracture Fixation - statistics & numerical data ; Fractures, Compression - diagnostic imaging ; Fractures, Compression - epidemiology ; Fractures, Compression - etiology ; Fractures, Compression - surgery ; GY RANGE 01-10 ; GY RANGE 10-100 ; Hematologic Neoplasms - complications ; Hematology, Oncology and Palliative Medicine ; Humans ; Magnetic Resonance Imaging ; Male ; MEDICAL RECORDS ; Middle Aged ; MULTIVARIATE ANALYSIS ; NMR IMAGING ; PATIENTS ; Radiology ; RADIOLOGY AND NUCLEAR MEDICINE ; Radiosurgery - adverse effects ; Radiosurgery - statistics & numerical data ; RADIOTHERAPY ; Radiotherapy Dosage ; Retrospective Studies ; Risk Factors ; Sex Factors ; Spinal Fractures - diagnostic imaging ; Spinal Fractures - epidemiology ; Spinal Fractures - etiology ; Spinal Fractures - surgery ; Spinal Neoplasms - radiotherapy ; Spinal Neoplasms - secondary ; SURGERY ; Tomography, X-Ray Computed ; VERTEBRAE</subject><ispartof>International journal of radiation oncology, biology, physics, 2017-02, Vol.97 (2), p.236-245</ispartof><rights>Elsevier Inc.</rights><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-27daa141f71d5a234b3d3abbb2a9bb7e1cf9033083ecdbc34197b5543c5570e23</citedby><cites>FETCH-LOGICAL-c445t-27daa141f71d5a234b3d3abbb2a9bb7e1cf9033083ecdbc34197b5543c5570e23</cites><orcidid>0000-0001-6057-7176</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijrobp.2016.09.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28068232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22645759$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Boyce-Fappiano, David, BSc</creatorcontrib><creatorcontrib>Elibe, Erinma, BS</creatorcontrib><creatorcontrib>Schultz, Lonni, PhD</creatorcontrib><creatorcontrib>Ryu, Samuel, MD</creatorcontrib><creatorcontrib>Siddiqui, M. Salim, MD, PhD</creatorcontrib><creatorcontrib>Chetty, Indrin, PhD</creatorcontrib><creatorcontrib>Lee, Ian, MD</creatorcontrib><creatorcontrib>Rock, Jack, MD</creatorcontrib><creatorcontrib>Movsas, Benjamin, MD</creatorcontrib><creatorcontrib>Siddiqui, Farzan, MD, PhD</creatorcontrib><title>Analysis of the Factors Contributing to Vertebral Compression Fractures After Spine Stereotactic Radiosurgery</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Purpose To determine our institutional vertebral compression fracture (VCF) rate after spine stereotactic radiosurgery (SRS) and determine contributory factors. Methods and Materials Retrospective analysis from 2001 to 2013 at a single institution was performed. With institutional review board approval, electronic medical records of 1905 vertebral bodies from 791 patients who were treated with SRS for the management of primary or metastatic spinal lesions were reviewed. A total of 448 patients (1070 vertebral bodies) with adequate follow-up imaging studies available were analyzed. Doses ranging from 10 Gy in 1 fraction to 60 Gy in 5 fractions were delivered. Computed tomography and magnetic resonance imaging were used to evaluate the primary endpoints of this study: development of a new VCF, progression of an existing VCF, and requirement of stabilization surgery after SRS. Results A total of 127 VCFs (11.9%; 95% confidence interval [CI] 9.5%-14.2%) in 97 patients were potentially SRS induced: 46 (36%) were de novo, 44 (35%) VCFs progressed, and 37 (29%) required stabilization surgery after SRS. Our rate for radiologic VCF development/progression (excluding patients who underwent surgery) was 8.4%. Upon further exclusion of patients with hematologic malignancies the VCF rate was 7.6%. In the univariate analyses, females (hazard ratio [HR] 1.54, 95% CI 1.01-2.33, P =.04), prior VCF (HR 1.99, 95% CI 1.30-3.06, P =.001), primary hematologic malignancies (HR 2.68, 95% CI 1.68-4.28, P <.001), thoracic spine lesions (HR 1.46, 95% CI 1.02-2.10, P =.02), and lytic lesions had a significantly increased risk for VCF after SRS. On multivariate analyses, prior VCF and lesion type remained contributory. Conclusions Single-fraction SRS doses of 16 to 18 Gy to the spine seem to be associated with a low rate of VCFs. To the best of our knowledge, this is the largest reported experience analyzing SRS-induced VCFs, with one of the lowest event rates reported.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis of Variance</subject><subject>BIOMEDICAL RADIOGRAPHY</subject><subject>COMPRESSION</subject><subject>COMPUTERIZED TOMOGRAPHY</subject><subject>Confidence Intervals</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Fracture Fixation - methods</subject><subject>Fracture Fixation - statistics & numerical data</subject><subject>Fractures, Compression - diagnostic imaging</subject><subject>Fractures, Compression - epidemiology</subject><subject>Fractures, Compression - etiology</subject><subject>Fractures, Compression - surgery</subject><subject>GY RANGE 01-10</subject><subject>GY RANGE 10-100</subject><subject>Hematologic Neoplasms - complications</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>MEDICAL RECORDS</subject><subject>Middle Aged</subject><subject>MULTIVARIATE ANALYSIS</subject><subject>NMR IMAGING</subject><subject>PATIENTS</subject><subject>Radiology</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Radiosurgery - adverse effects</subject><subject>Radiosurgery - statistics & numerical data</subject><subject>RADIOTHERAPY</subject><subject>Radiotherapy Dosage</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Spinal Fractures - diagnostic imaging</subject><subject>Spinal Fractures - epidemiology</subject><subject>Spinal Fractures - etiology</subject><subject>Spinal Fractures - surgery</subject><subject>Spinal Neoplasms - radiotherapy</subject><subject>Spinal Neoplasms - secondary</subject><subject>SURGERY</subject><subject>Tomography, X-Ray Computed</subject><subject>VERTEBRAE</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks-L1DAUx4so7rj6H4gEvHjpmJ9NexGGYUeFBcFR8RaS9HU3tW1qkgrz35vS1YMXT8njfd7P7yuKlwTvCSbV237v-uDNvKfZ2uNmj7F8VOxILZuSCfH9cbHDrMIly-6r4lmMPcaYEMmfFle0xlVNGd0V42HSwyW6iHyH0j2gk7bJh4iOfkrBmSW56Q4lj75BSGCCHrJnnAPE6PyETiHjS7bQoUsQ0Hl2E6Bz_oJP2eUs-qxb5-MS7iBcnhdPOj1EePHwXhdfTzdfjh_K20_vPx4Pt6XlXKSSylZrwkknSSs0ZdywlmljDNWNMRKI7RrMGK4Z2NZYxkkjjRCcWSEkBsqui9dbXh-TU9G6BPbe-mkCmxSlFRdSNJl6s1Fz8D8XiEmNLloYBj2BX6IitZBMStbwjPINtcHHGKBTc3CjDhdFsFrlUL3a5FCrHAo3KsuRw149VFjMCO3foD_7z8C7DYC8jV8OwtosTBZaF9ZeW-_-V-HfBHZwk7N6-AEXiL1fQhY4z6IiVVid15NYL4JUjBFZCfYb5seztA</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Boyce-Fappiano, David, BSc</creator><creator>Elibe, Erinma, BS</creator><creator>Schultz, Lonni, PhD</creator><creator>Ryu, Samuel, MD</creator><creator>Siddiqui, M. Salim, MD, PhD</creator><creator>Chetty, Indrin, PhD</creator><creator>Lee, Ian, MD</creator><creator>Rock, Jack, MD</creator><creator>Movsas, Benjamin, MD</creator><creator>Siddiqui, Farzan, MD, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope><orcidid>https://orcid.org/0000-0001-6057-7176</orcidid></search><sort><creationdate>20170201</creationdate><title>Analysis of the Factors Contributing to Vertebral Compression Fractures After Spine Stereotactic Radiosurgery</title><author>Boyce-Fappiano, David, BSc ; Elibe, Erinma, BS ; Schultz, Lonni, PhD ; Ryu, Samuel, MD ; Siddiqui, M. Salim, MD, PhD ; Chetty, Indrin, PhD ; Lee, Ian, MD ; Rock, Jack, MD ; Movsas, Benjamin, MD ; Siddiqui, Farzan, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-27daa141f71d5a234b3d3abbb2a9bb7e1cf9033083ecdbc34197b5543c5570e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis of Variance</topic><topic>BIOMEDICAL RADIOGRAPHY</topic><topic>COMPRESSION</topic><topic>COMPUTERIZED TOMOGRAPHY</topic><topic>Confidence Intervals</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Fracture Fixation - methods</topic><topic>Fracture Fixation - statistics & numerical data</topic><topic>Fractures, Compression - diagnostic imaging</topic><topic>Fractures, Compression - epidemiology</topic><topic>Fractures, Compression - etiology</topic><topic>Fractures, Compression - surgery</topic><topic>GY RANGE 01-10</topic><topic>GY RANGE 10-100</topic><topic>Hematologic Neoplasms - complications</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>MEDICAL RECORDS</topic><topic>Middle Aged</topic><topic>MULTIVARIATE ANALYSIS</topic><topic>NMR IMAGING</topic><topic>PATIENTS</topic><topic>Radiology</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Radiosurgery - adverse effects</topic><topic>Radiosurgery - statistics & numerical data</topic><topic>RADIOTHERAPY</topic><topic>Radiotherapy Dosage</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Spinal Fractures - diagnostic imaging</topic><topic>Spinal Fractures - epidemiology</topic><topic>Spinal Fractures - etiology</topic><topic>Spinal Fractures - surgery</topic><topic>Spinal Neoplasms - radiotherapy</topic><topic>Spinal Neoplasms - secondary</topic><topic>SURGERY</topic><topic>Tomography, X-Ray Computed</topic><topic>VERTEBRAE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boyce-Fappiano, David, BSc</creatorcontrib><creatorcontrib>Elibe, Erinma, BS</creatorcontrib><creatorcontrib>Schultz, Lonni, PhD</creatorcontrib><creatorcontrib>Ryu, Samuel, MD</creatorcontrib><creatorcontrib>Siddiqui, M. Salim, MD, PhD</creatorcontrib><creatorcontrib>Chetty, Indrin, PhD</creatorcontrib><creatorcontrib>Lee, Ian, MD</creatorcontrib><creatorcontrib>Rock, Jack, MD</creatorcontrib><creatorcontrib>Movsas, Benjamin, MD</creatorcontrib><creatorcontrib>Siddiqui, Farzan, MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boyce-Fappiano, David, BSc</au><au>Elibe, Erinma, BS</au><au>Schultz, Lonni, PhD</au><au>Ryu, Samuel, MD</au><au>Siddiqui, M. Salim, MD, PhD</au><au>Chetty, Indrin, PhD</au><au>Lee, Ian, MD</au><au>Rock, Jack, MD</au><au>Movsas, Benjamin, MD</au><au>Siddiqui, Farzan, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of the Factors Contributing to Vertebral Compression Fractures After Spine Stereotactic Radiosurgery</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>97</volume><issue>2</issue><spage>236</spage><epage>245</epage><pages>236-245</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><abstract>Purpose To determine our institutional vertebral compression fracture (VCF) rate after spine stereotactic radiosurgery (SRS) and determine contributory factors. Methods and Materials Retrospective analysis from 2001 to 2013 at a single institution was performed. With institutional review board approval, electronic medical records of 1905 vertebral bodies from 791 patients who were treated with SRS for the management of primary or metastatic spinal lesions were reviewed. A total of 448 patients (1070 vertebral bodies) with adequate follow-up imaging studies available were analyzed. Doses ranging from 10 Gy in 1 fraction to 60 Gy in 5 fractions were delivered. Computed tomography and magnetic resonance imaging were used to evaluate the primary endpoints of this study: development of a new VCF, progression of an existing VCF, and requirement of stabilization surgery after SRS. Results A total of 127 VCFs (11.9%; 95% confidence interval [CI] 9.5%-14.2%) in 97 patients were potentially SRS induced: 46 (36%) were de novo, 44 (35%) VCFs progressed, and 37 (29%) required stabilization surgery after SRS. Our rate for radiologic VCF development/progression (excluding patients who underwent surgery) was 8.4%. Upon further exclusion of patients with hematologic malignancies the VCF rate was 7.6%. In the univariate analyses, females (hazard ratio [HR] 1.54, 95% CI 1.01-2.33, P =.04), prior VCF (HR 1.99, 95% CI 1.30-3.06, P =.001), primary hematologic malignancies (HR 2.68, 95% CI 1.68-4.28, P <.001), thoracic spine lesions (HR 1.46, 95% CI 1.02-2.10, P =.02), and lytic lesions had a significantly increased risk for VCF after SRS. On multivariate analyses, prior VCF and lesion type remained contributory. Conclusions Single-fraction SRS doses of 16 to 18 Gy to the spine seem to be associated with a low rate of VCFs. To the best of our knowledge, this is the largest reported experience analyzing SRS-induced VCFs, with one of the lowest event rates reported.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28068232</pmid><doi>10.1016/j.ijrobp.2016.09.007</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-6057-7176</orcidid></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Analysis of Variance BIOMEDICAL RADIOGRAPHY COMPRESSION COMPUTERIZED TOMOGRAPHY Confidence Intervals Disease Progression Female Fracture Fixation - methods Fracture Fixation - statistics & numerical data Fractures, Compression - diagnostic imaging Fractures, Compression - epidemiology Fractures, Compression - etiology Fractures, Compression - surgery GY RANGE 01-10 GY RANGE 10-100 Hematologic Neoplasms - complications Hematology, Oncology and Palliative Medicine Humans Magnetic Resonance Imaging Male MEDICAL RECORDS Middle Aged MULTIVARIATE ANALYSIS NMR IMAGING PATIENTS Radiology RADIOLOGY AND NUCLEAR MEDICINE Radiosurgery - adverse effects Radiosurgery - statistics & numerical data RADIOTHERAPY Radiotherapy Dosage Retrospective Studies Risk Factors Sex Factors Spinal Fractures - diagnostic imaging Spinal Fractures - epidemiology Spinal Fractures - etiology Spinal Fractures - surgery Spinal Neoplasms - radiotherapy Spinal Neoplasms - secondary SURGERY Tomography, X-Ray Computed VERTEBRAE |
| title | Analysis of the Factors Contributing to Vertebral Compression Fractures After Spine Stereotactic Radiosurgery |
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