In Vivo Imaging Reveals Significant Tumor Vascular Dysfunction and Increased Tumor Hypoxia-Inducible Factor-1α Expression Induced by High Single-Dose Irradiation in a Pancreatic Tumor Model

Purpose To investigate the effect of high-dose irradiation on pancreatic tumor vasculature and microenvironment using in vivo imaging techniques. Methods and Materials A BxPC3 pancreatic tumor xenograft was established in a dorsal skinfold window chamber model and a subcutaneous hind leg model. Tumo...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2017-01, Vol.97 (1), p.184-194
Hauptverfasser:	Maeda, Azusa, PhD, Chen, Yonghong, MSc, MD, Bu, Jiachuan, MSc, Mujcic, Hilda, PhD, Wouters, Bradly G., PhD, DaCosta, Ralph S., PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BIOMEDICAL RADIOGRAPHY Capillary Permeability - radiation effects Cell Adhesion - radiation effects Cell Hypoxia Endothelium, Vascular Female GY RANGE 10-100 Hematology, Oncology and Palliative Medicine Heterografts Hindlimb Hypoxia-Inducible Factor 1, alpha Subunit - metabolism IN VIVO IRRADIATION LEGS Leukocytes - radiation effects Mice, Inbred NOD Microscopy, Fluorescence Neoplasm Recurrence, Local NEOPLASMS PANCREAS Pancreatic Neoplasms - blood supply Pancreatic Neoplasms - diagnostic imaging Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - radiotherapy Platelet Adhesiveness - radiation effects RADIATION DOSES Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy Dosage Time Factors Tumor Burden Tumor Microenvironment - radiation effects Ultrasonography
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