Association Between Radiation Necrosis and Tumor Biology After Stereotactic Radiosurgery for Brain Metastasis

Background The primary dose-limiting toxicity of stereotactic radiosurgery (SRS) is radiation necrosis (RN), which occurs after approximately 5% to 10% of treatments. This adverse event may worsen neurologic deficits, increase the frequency and cost of imaging, and necessitate prolonged treatment wi...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2016-12, Vol.96 (5), p.1060-1069
Hauptverfasser:	Miller, Jacob A., BS, Bennett, Elizabeth E., MD, Xiao, Roy, BS, Kotecha, Rupesh, MD, Chao, Samuel T., MD, Vogelbaum, Michael A., MD, PhD, Barnett, Gene H., MD, MBA, Angelov, Lilyana, MD, Murphy, Erin S., MD, Yu, Jennifer S., MD, PhD, Ahluwalia, Manmeet S., MD, Suh, John H., MD, Mohammadi, Alireza M., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - pathology Adenocarcinoma - secondary BIOMEDICAL RADIOGRAPHY BRAIN Brain - pathology Brain - radiation effects Brain Neoplasms - chemistry Brain Neoplasms - genetics Brain Neoplasms - radiotherapy Brain Neoplasms - secondary Breast Neoplasms - genetics Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Squamous Cell - genetics CLINICAL TRIALS Female Gene Amplification Genes, erbB-2 Hematology, Oncology and Palliative Medicine HISTOLOGY Humans Lung Neoplasms - pathology Male Melanoma - genetics Middle Aged MULTIVARIATE ANALYSIS NECROSIS Necrosis - diagnostic imaging Necrosis - etiology Necrosis - genetics PATIENTS Proto-Oncogene Proteins B-raf Radiation Injuries - complications Radiation Injuries - diagnostic imaging Radiation Injuries - pathology Radiology RADIOLOGY AND NUCLEAR MEDICINE Radiosurgery - adverse effects RADIOTHERAPY Regression Analysis Retrospective Studies SURGERY
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