Nicotinamide Phosphoribosyltransferase Upregulation by Phenylephrine Reduces Radiation Injury in Submandibular Gland

Radiation therapy for head and neck cancer commonly leads to radiation sialadenitis. Emerging evidence has indicated that phenylephrine pretreatment reduces radiosensitivity in the salivary gland; however, the underlying cytoprotective mechanism remains unclear. Nicotinamide phosphoribosyltransferas...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2016-11, Vol.96 (3), p.538-546
Hauptverfasser:	Xiang, Bin, Han, Lichi, Wang, Xinyue, Tang, Ling, Li, Kailiang, Li, Xiuxiu, Zhao, Xibo, Xia, Miaomiao, Zhou, Xixi, Zhang, Fuyin, Liu, Ke Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CELL NUCLEI Cell Survival - drug effects Cell Survival - radiation effects Cells, Cultured Dose-Response Relationship, Drug Dose-Response Relationship, Radiation Female IN VITRO IN VIVO IRRADIATION Male NICOTINAMIDE Nicotinamide Phosphoribosyltransferase - biosynthesis Phenylephrine - administration & dosage POLYMERASE CHAIN REACTION Radiation Dosage RADIATION INJURIES Radiation-Protective Agents - administration & dosage RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Rats Rats, Wistar SALIVARY GLANDS Submandibular Gland - drug effects Submandibular Gland - enzymology Submandibular Gland - physiopathology Submandibular Gland - radiation effects Treatment Outcome Up-Regulation - drug effects
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