Stabilization Improves Theranostic Properties of Lipiodol®-Based Emulsion During Liver Trans-arterial Chemo-embolization in a VX2 Rabbit Model
Purpose To demonstrate that stability is a crucial parameter for theranostic properties of Lipiodol ® -based emulsions during liver trans-arterial chemo-embolization. Materials and Methods We compared the theranostic properties of two emulsions made of Lipiodol ® and doxorubicin in two successive an...
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| Veröffentlicht in: | Cardiovascular and interventional radiology 2017-06, Vol.40 (6), p.907-913 |
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| creator | Deschamps, F. Farouil, G. Gonzalez, W. Robic, C. Paci, A. Mir, L. M. Tselikas, L. de Baère, T. |
| description | Purpose
To demonstrate that stability is a crucial parameter for theranostic properties of Lipiodol
®
-based emulsions during liver trans-arterial chemo-embolization.
Materials and Methods
We compared the theranostic properties of two emulsions made of Lipiodol
®
and doxorubicin in two successive animal experiments (One VX2 tumour implanted in the left liver lobe of 30 rabbits). Emulsion-1 reproduced one of the most common way of preparation (ratio of oil/water: 1/1), and emulsion-2 was designed to obtain a water-in-oil emulsion with enhanced stability (ratio of oil/water: 3/1, plus an emulsifier). The first animal experiment compared the tumour selectivity of the two emulsions: seven rabbits received left hepatic arterial infusion (HAI) of emulsion-1 and eight received HAI of emulsion-2. 3D-CBCT acquisitions were acquired after HAI of every 0.1 mL to measure the densities’ ratios between the tumours and the left liver lobes. The second animal experiment compared the plasmatic and tumour doxorubicin concentrations after HAI of 1.5 mg of doxorubicin administered either alone (
n
= 3) or in emulsion-1 (
n
= 6) or in emulsion-2 (
n
= 6).
Results
Emulsion-2 resulted in densities’ ratios between the tumours and the left liver lobes that were significantly higher compared to emulsion-1 (up to 0.4 mL infused). Plasmatic doxorubicin concentrations (at 5 min) were significantly lower after HAI of emulsion-2 (19.0 μg/L) than emulsion-1 (275.3 μg/L,
p
|
| doi_str_mv | 10.1007/s00270-017-1616-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_22645165</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1875405040</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-fdf9268cf452b1cbaa92d52be3e64003f773e8d44d50483be98f28234efcdaae3</originalsourceid><addsrcrecordid>eNp9kcGO1SAYhYnRONfRB3BjSNy4QYFC27vU6zgzyTUavZrZEQo_XiZtqUAn0ZfwTXwIn0yajrN0BYHvnD__OQg9ZfQlo7R5lSjlDSWUNYTVrCb8HtowUXFC2_rqPtqUD0GYlOwEPUrpmlImWy4fohPe8oZVfLtBvz5n3fne_9TZhxFfDlMMN5Dw4QhRjyFlb_DHGCaI2Zfn4PDeTz7Y0P_5Td7oBBafDXOfFvHbOfrxWwFuIOJDkSeiY4bodY93RxgCgaELd7P8iDX-esXxJ911PuP3wUL_GD1wuk_w5PY8RV_enR12F2T_4fxy93pPTNXwTJx1W163xgnJO2Y6rbfclitUUAtKK9c0FbRWCCupaKsOtq0rS1cCnLFaQ3WKnq--y4oqGZ_BHE0YRzBZcV4LyWpZqBcrVVL5PkPKavDJQN_rEcKcFGsbKWgZQQvKVtTEkFIEp6boBx1_KEbV0pZa21KlFLW0pXjRPLu1n7sB7J3iXz0F4CuQpiVaiOo6zHEswfzH9S_KhqJT</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1875405040</pqid></control><display><type>article</type><title>Stabilization Improves Theranostic Properties of Lipiodol®-Based Emulsion During Liver Trans-arterial Chemo-embolization in a VX2 Rabbit Model</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Deschamps, F. ; Farouil, G. ; Gonzalez, W. ; Robic, C. ; Paci, A. ; Mir, L. M. ; Tselikas, L. ; de Baère, T.</creator><creatorcontrib>Deschamps, F. ; Farouil, G. ; Gonzalez, W. ; Robic, C. ; Paci, A. ; Mir, L. M. ; Tselikas, L. ; de Baère, T.</creatorcontrib><description>Purpose
To demonstrate that stability is a crucial parameter for theranostic properties of Lipiodol
®
-based emulsions during liver trans-arterial chemo-embolization.
Materials and Methods
We compared the theranostic properties of two emulsions made of Lipiodol
®
and doxorubicin in two successive animal experiments (One VX2 tumour implanted in the left liver lobe of 30 rabbits). Emulsion-1 reproduced one of the most common way of preparation (ratio of oil/water: 1/1), and emulsion-2 was designed to obtain a water-in-oil emulsion with enhanced stability (ratio of oil/water: 3/1, plus an emulsifier). The first animal experiment compared the tumour selectivity of the two emulsions: seven rabbits received left hepatic arterial infusion (HAI) of emulsion-1 and eight received HAI of emulsion-2. 3D-CBCT acquisitions were acquired after HAI of every 0.1 mL to measure the densities’ ratios between the tumours and the left liver lobes. The second animal experiment compared the plasmatic and tumour doxorubicin concentrations after HAI of 1.5 mg of doxorubicin administered either alone (
n
= 3) or in emulsion-1 (
n
= 6) or in emulsion-2 (
n
= 6).
Results
Emulsion-2 resulted in densities’ ratios between the tumours and the left liver lobes that were significantly higher compared to emulsion-1 (up to 0.4 mL infused). Plasmatic doxorubicin concentrations (at 5 min) were significantly lower after HAI of emulsion-2 (19.0 μg/L) than emulsion-1 (275.3 μg/L,
p
< 0.01) and doxorubicin alone (412.0 μg/L,
p
< 0.001), and tumour doxorubicin concentration (day-1) was significantly higher after HAI of emulsion-2 (20,957 ng/g) than in emulsion-1 (8093 ng/g,
p
< 0.05) and doxorubicin alone (2221 ng/g,
p
< 0.01).
Conclusion
Stabilization of doxorubicin in a water-in-oil Lipiodol
®
-based emulsion results in better theranostic properties.</description><identifier>ISSN: 0174-1551</identifier><identifier>EISSN: 1432-086X</identifier><identifier>DOI: 10.1007/s00270-017-1616-2</identifier><identifier>PMID: 28271329</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>ABUNDANCE ; Animals ; Cardiology ; Chemoembolization, Therapeutic - methods ; COMPARATIVE EVALUATIONS ; COMPUTERIZED TOMOGRAPHY ; CONCENTRATION RATIO ; Disease Models, Animal ; DOXORUBICIN ; Doxorubicin - administration & dosage ; ECOLOGICAL CONCENTRATION ; EMULSIFIERS ; EMULSIONS ; Ethiodized Oil - administration & dosage ; Imaging ; INFUSION ; Laboratory Investigation ; LIPIODOL ; LIVER ; Liver Neoplasms, Experimental - therapy ; Medicine ; Medicine & Public Health ; NEOPLASMS ; Nuclear Medicine ; RABBITS ; Radiology ; RADIOLOGY AND NUCLEAR MEDICINE ; STABILITY ; STABILIZATION ; Theranostic Nanomedicine - methods ; Ultrasound ; VASCULAR DISEASES</subject><ispartof>Cardiovascular and interventional radiology, 2017-06, Vol.40 (6), p.907-913</ispartof><rights>Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-fdf9268cf452b1cbaa92d52be3e64003f773e8d44d50483be98f28234efcdaae3</citedby><cites>FETCH-LOGICAL-c372t-fdf9268cf452b1cbaa92d52be3e64003f773e8d44d50483be98f28234efcdaae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00270-017-1616-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00270-017-1616-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28271329$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22645165$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Deschamps, F.</creatorcontrib><creatorcontrib>Farouil, G.</creatorcontrib><creatorcontrib>Gonzalez, W.</creatorcontrib><creatorcontrib>Robic, C.</creatorcontrib><creatorcontrib>Paci, A.</creatorcontrib><creatorcontrib>Mir, L. M.</creatorcontrib><creatorcontrib>Tselikas, L.</creatorcontrib><creatorcontrib>de Baère, T.</creatorcontrib><title>Stabilization Improves Theranostic Properties of Lipiodol®-Based Emulsion During Liver Trans-arterial Chemo-embolization in a VX2 Rabbit Model</title><title>Cardiovascular and interventional radiology</title><addtitle>Cardiovasc Intervent Radiol</addtitle><addtitle>Cardiovasc Intervent Radiol</addtitle><description>Purpose
To demonstrate that stability is a crucial parameter for theranostic properties of Lipiodol
®
-based emulsions during liver trans-arterial chemo-embolization.
Materials and Methods
We compared the theranostic properties of two emulsions made of Lipiodol
®
and doxorubicin in two successive animal experiments (One VX2 tumour implanted in the left liver lobe of 30 rabbits). Emulsion-1 reproduced one of the most common way of preparation (ratio of oil/water: 1/1), and emulsion-2 was designed to obtain a water-in-oil emulsion with enhanced stability (ratio of oil/water: 3/1, plus an emulsifier). The first animal experiment compared the tumour selectivity of the two emulsions: seven rabbits received left hepatic arterial infusion (HAI) of emulsion-1 and eight received HAI of emulsion-2. 3D-CBCT acquisitions were acquired after HAI of every 0.1 mL to measure the densities’ ratios between the tumours and the left liver lobes. The second animal experiment compared the plasmatic and tumour doxorubicin concentrations after HAI of 1.5 mg of doxorubicin administered either alone (
n
= 3) or in emulsion-1 (
n
= 6) or in emulsion-2 (
n
= 6).
Results
Emulsion-2 resulted in densities’ ratios between the tumours and the left liver lobes that were significantly higher compared to emulsion-1 (up to 0.4 mL infused). Plasmatic doxorubicin concentrations (at 5 min) were significantly lower after HAI of emulsion-2 (19.0 μg/L) than emulsion-1 (275.3 μg/L,
p
< 0.01) and doxorubicin alone (412.0 μg/L,
p
< 0.001), and tumour doxorubicin concentration (day-1) was significantly higher after HAI of emulsion-2 (20,957 ng/g) than in emulsion-1 (8093 ng/g,
p
< 0.05) and doxorubicin alone (2221 ng/g,
p
< 0.01).
Conclusion
Stabilization of doxorubicin in a water-in-oil Lipiodol
®
-based emulsion results in better theranostic properties.</description><subject>ABUNDANCE</subject><subject>Animals</subject><subject>Cardiology</subject><subject>Chemoembolization, Therapeutic - methods</subject><subject>COMPARATIVE EVALUATIONS</subject><subject>COMPUTERIZED TOMOGRAPHY</subject><subject>CONCENTRATION RATIO</subject><subject>Disease Models, Animal</subject><subject>DOXORUBICIN</subject><subject>Doxorubicin - administration & dosage</subject><subject>ECOLOGICAL CONCENTRATION</subject><subject>EMULSIFIERS</subject><subject>EMULSIONS</subject><subject>Ethiodized Oil - administration & dosage</subject><subject>Imaging</subject><subject>INFUSION</subject><subject>Laboratory Investigation</subject><subject>LIPIODOL</subject><subject>LIVER</subject><subject>Liver Neoplasms, Experimental - therapy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>NEOPLASMS</subject><subject>Nuclear Medicine</subject><subject>RABBITS</subject><subject>Radiology</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>STABILITY</subject><subject>STABILIZATION</subject><subject>Theranostic Nanomedicine - methods</subject><subject>Ultrasound</subject><subject>VASCULAR DISEASES</subject><issn>0174-1551</issn><issn>1432-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcGO1SAYhYnRONfRB3BjSNy4QYFC27vU6zgzyTUavZrZEQo_XiZtqUAn0ZfwTXwIn0yajrN0BYHvnD__OQg9ZfQlo7R5lSjlDSWUNYTVrCb8HtowUXFC2_rqPtqUD0GYlOwEPUrpmlImWy4fohPe8oZVfLtBvz5n3fne_9TZhxFfDlMMN5Dw4QhRjyFlb_DHGCaI2Zfn4PDeTz7Y0P_5Td7oBBafDXOfFvHbOfrxWwFuIOJDkSeiY4bodY93RxgCgaELd7P8iDX-esXxJ911PuP3wUL_GD1wuk_w5PY8RV_enR12F2T_4fxy93pPTNXwTJx1W163xgnJO2Y6rbfclitUUAtKK9c0FbRWCCupaKsOtq0rS1cCnLFaQ3WKnq--y4oqGZ_BHE0YRzBZcV4LyWpZqBcrVVL5PkPKavDJQN_rEcKcFGsbKWgZQQvKVtTEkFIEp6boBx1_KEbV0pZa21KlFLW0pXjRPLu1n7sB7J3iXz0F4CuQpiVaiOo6zHEswfzH9S_KhqJT</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Deschamps, F.</creator><creator>Farouil, G.</creator><creator>Gonzalez, W.</creator><creator>Robic, C.</creator><creator>Paci, A.</creator><creator>Mir, L. M.</creator><creator>Tselikas, L.</creator><creator>de Baère, T.</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>20170601</creationdate><title>Stabilization Improves Theranostic Properties of Lipiodol®-Based Emulsion During Liver Trans-arterial Chemo-embolization in a VX2 Rabbit Model</title><author>Deschamps, F. ; Farouil, G. ; Gonzalez, W. ; Robic, C. ; Paci, A. ; Mir, L. M. ; Tselikas, L. ; de Baère, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-fdf9268cf452b1cbaa92d52be3e64003f773e8d44d50483be98f28234efcdaae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>ABUNDANCE</topic><topic>Animals</topic><topic>Cardiology</topic><topic>Chemoembolization, Therapeutic - methods</topic><topic>COMPARATIVE EVALUATIONS</topic><topic>COMPUTERIZED TOMOGRAPHY</topic><topic>CONCENTRATION RATIO</topic><topic>Disease Models, Animal</topic><topic>DOXORUBICIN</topic><topic>Doxorubicin - administration & dosage</topic><topic>ECOLOGICAL CONCENTRATION</topic><topic>EMULSIFIERS</topic><topic>EMULSIONS</topic><topic>Ethiodized Oil - administration & dosage</topic><topic>Imaging</topic><topic>INFUSION</topic><topic>Laboratory Investigation</topic><topic>LIPIODOL</topic><topic>LIVER</topic><topic>Liver Neoplasms, Experimental - therapy</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>NEOPLASMS</topic><topic>Nuclear Medicine</topic><topic>RABBITS</topic><topic>Radiology</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>STABILITY</topic><topic>STABILIZATION</topic><topic>Theranostic Nanomedicine - methods</topic><topic>Ultrasound</topic><topic>VASCULAR DISEASES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deschamps, F.</creatorcontrib><creatorcontrib>Farouil, G.</creatorcontrib><creatorcontrib>Gonzalez, W.</creatorcontrib><creatorcontrib>Robic, C.</creatorcontrib><creatorcontrib>Paci, A.</creatorcontrib><creatorcontrib>Mir, L. M.</creatorcontrib><creatorcontrib>Tselikas, L.</creatorcontrib><creatorcontrib>de Baère, T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Cardiovascular and interventional radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deschamps, F.</au><au>Farouil, G.</au><au>Gonzalez, W.</au><au>Robic, C.</au><au>Paci, A.</au><au>Mir, L. M.</au><au>Tselikas, L.</au><au>de Baère, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stabilization Improves Theranostic Properties of Lipiodol®-Based Emulsion During Liver Trans-arterial Chemo-embolization in a VX2 Rabbit Model</atitle><jtitle>Cardiovascular and interventional radiology</jtitle><stitle>Cardiovasc Intervent Radiol</stitle><addtitle>Cardiovasc Intervent Radiol</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>40</volume><issue>6</issue><spage>907</spage><epage>913</epage><pages>907-913</pages><issn>0174-1551</issn><eissn>1432-086X</eissn><abstract>Purpose
To demonstrate that stability is a crucial parameter for theranostic properties of Lipiodol
®
-based emulsions during liver trans-arterial chemo-embolization.
Materials and Methods
We compared the theranostic properties of two emulsions made of Lipiodol
®
and doxorubicin in two successive animal experiments (One VX2 tumour implanted in the left liver lobe of 30 rabbits). Emulsion-1 reproduced one of the most common way of preparation (ratio of oil/water: 1/1), and emulsion-2 was designed to obtain a water-in-oil emulsion with enhanced stability (ratio of oil/water: 3/1, plus an emulsifier). The first animal experiment compared the tumour selectivity of the two emulsions: seven rabbits received left hepatic arterial infusion (HAI) of emulsion-1 and eight received HAI of emulsion-2. 3D-CBCT acquisitions were acquired after HAI of every 0.1 mL to measure the densities’ ratios between the tumours and the left liver lobes. The second animal experiment compared the plasmatic and tumour doxorubicin concentrations after HAI of 1.5 mg of doxorubicin administered either alone (
n
= 3) or in emulsion-1 (
n
= 6) or in emulsion-2 (
n
= 6).
Results
Emulsion-2 resulted in densities’ ratios between the tumours and the left liver lobes that were significantly higher compared to emulsion-1 (up to 0.4 mL infused). Plasmatic doxorubicin concentrations (at 5 min) were significantly lower after HAI of emulsion-2 (19.0 μg/L) than emulsion-1 (275.3 μg/L,
p
< 0.01) and doxorubicin alone (412.0 μg/L,
p
< 0.001), and tumour doxorubicin concentration (day-1) was significantly higher after HAI of emulsion-2 (20,957 ng/g) than in emulsion-1 (8093 ng/g,
p
< 0.05) and doxorubicin alone (2221 ng/g,
p
< 0.01).
Conclusion
Stabilization of doxorubicin in a water-in-oil Lipiodol
®
-based emulsion results in better theranostic properties.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28271329</pmid><doi>10.1007/s00270-017-1616-2</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0174-1551 |
| ispartof | Cardiovascular and interventional radiology, 2017-06, Vol.40 (6), p.907-913 |
| issn | 0174-1551 1432-086X |
| language | eng |
| recordid | cdi_osti_scitechconnect_22645165 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | ABUNDANCE Animals Cardiology Chemoembolization, Therapeutic - methods COMPARATIVE EVALUATIONS COMPUTERIZED TOMOGRAPHY CONCENTRATION RATIO Disease Models, Animal DOXORUBICIN Doxorubicin - administration & dosage ECOLOGICAL CONCENTRATION EMULSIFIERS EMULSIONS Ethiodized Oil - administration & dosage Imaging INFUSION Laboratory Investigation LIPIODOL LIVER Liver Neoplasms, Experimental - therapy Medicine Medicine & Public Health NEOPLASMS Nuclear Medicine RABBITS Radiology RADIOLOGY AND NUCLEAR MEDICINE STABILITY STABILIZATION Theranostic Nanomedicine - methods Ultrasound VASCULAR DISEASES |
| title | Stabilization Improves Theranostic Properties of Lipiodol®-Based Emulsion During Liver Trans-arterial Chemo-embolization in a VX2 Rabbit Model |
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