Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model

Purpose To test the effects of a novel Mn porphyrin oxidative stress modifier, Mn(III) meso- tetrakis( N -n-butoxyethylpyridinium-2-yl)porphyrin (MnBuOE), for its radioprotective and radiosensitizing properties in normal tissue versus tumor, respectively. Methods and Materials Murine oral mucosa and...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2015-11, Vol.93 (4), p.892-900
Hauptverfasser:	Ashcraft, Kathleen A., PhD, Boss, Mary-Keara, DVM, Tovmasyan, Artak, PhD, Roy Choudhury, Kingshuk, PhD, Fontanella, Andrew N., PhD, Young, Kenneth H., BS, Palmer, Gregory M., PhD, Birer, Samuel R., BS, Landon, Chelsea D., PhD, Park, Won, MD, Das, Shiva K., PhD, Weitner, Tin, PhD, Sheng, Huaxin, MD, Warner, David S., MD, Brizel, David M., MD, Spasojevic, Ivan, PhD, Batinic-Haberle, Ines, PhD, Dewhirst, Mark W., DVM, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	ANIMAL TISSUES Animals BIOMEDICAL RADIOGRAPHY Dose-Response Relationship, Radiation Drug Evaluation, Preclinical - methods Fibrosis - etiology Fibrosis - prevention & control Head and Neck Neoplasms - radiotherapy Hematology, Oncology and Palliative Medicine Metalloporphyrins - pharmacokinetics Metalloporphyrins - therapeutic use Mice Mice, Inbred C57BL Mice, Nude Mouth Mucosa - radiation effects MUCOUS MEMBRANES NEOPLASMS Organs at Risk - pathology Organs at Risk - radiation effects PLANT TISSUES Radiation Dosage RADIATION DOSES RADIATION INJURIES Radiation Injuries, Experimental - prevention & control Radiation-Protective Agents - pharmacokinetics Radiation-Protective Agents - therapeutic use Radiation-Sensitizing Agents - pharmacokinetics Radiation-Sensitizing Agents - therapeutic use Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Random Allocation SALIVARY GLANDS Salivary Glands - pathology Salivary Glands - radiation effects Stomatitis - etiology Stomatitis - prevention & control Xerostomia - etiology Xerostomia - prevention & control
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